A kind of basmazone A and preparation method thereof

A technology of basma A and aspects, applied in the field of basma A and its preparation, can solve the problems such as less research on chemical components of oriental tobacco, achieve good anti-tobacco mosaic virus activity, broad application prospects, and structure. novel effect

Active Publication Date: 2020-11-24
YUNNAN AGRICULTURAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Yunxiang Basma No. 1 (YNOTBS1) is a new variety of oriental tobacco bred, mainly distributed in Yunna Baoshan, Lincang, Dehong and other production areas. At present, there are few studies on the chemical components of this oriental tobacco.

Method used

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  • A kind of basmazone A and preparation method thereof
  • A kind of basmazone A and preparation method thereof
  • A kind of basmazone A and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0032] The samples of this example were collected in the smoking area of ​​Dehong City, Yunnan Province.

[0033] The preparation of Basmazone A specifically includes the following steps:

[0034] 1) 10 kg of the lower part tobacco leaves of No. 1 spice smoke cloud Xiang Basma which were dried in the air, pulverized, and passed through a 40-mesh sieve as a raw material.

[0035] 2) soak the raw material obtained in step 1) with 10 times the amount (mass ratio) of analytically pure methanol solution for 10 hours, repeatedly extract 3 times, distill under reduced pressure until there is no alcohol smell, and concentrate to obtain 830 g of extract;

[0036] 3) Dissolve the extract obtained in step 2) in distilled water at a mass ratio of 1:1, extract with ethyl acetate, the mass ratio of the extract solution to ethyl acetate is 1:4, and recover the solvent until there is no ethyl acetate smell , Obtained 381 g of ethyl acetate fraction. The ethyl acetate part is mixed with sili...

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Abstract

The invention relates to Basma butyl-phthalide and a preparation method thereof, and belongs to the technical field of drugs and phytochemistry. The separation and obtaining of Basma butyl-phthalide comprise specific steps as follows: lower tobacco leaves of oriental tobacco Yunxiang basma No.1 are collected, dried in the shade and smashed, and the smashed leaves are screened by a 40-mesh sieve and taken as a raw material; the raw material is soaked in a methanol solution and extracted, reduced-pressure distillation and concentration are performed, and extract is obtained; the extract is subjected to extraction by ethyl acetate and subjected to silica gel column chromatography separation and HPLC (high performance liquid chromatograph) purification finally, and the pure compound is obtained. Basma butyl-phthalide is obtained by separation from the oriental tobacco Yunxiang basma No.1 for the first time, and the compound is novel in structure, has multiple biological activities, and particularly has better anti-TMV (tobacco mosaic virus) activity, thereby providing important enlightenment for further research of oriental tobacco plant as an anti-TMV medicinal plant resource and being capable of applying to research, development and preparation of anti-TMV drugs. The raw material is easily available, the preparation method is simple, the preparation cost is lower, and the application prospects are broad.

Description

technical field [0001] The invention belongs to the technical field of medicine and phytochemistry, and in particular relates to a basmamethanine and its preparation method and application. Background technique [0002] Oriental tobacco (Oriental tobacco) is an annual or limited perennial herbaceous plant belonging to Solanaceae Nicotiana. my country is the country with the largest tobacco planting area and total output in the world. It is planted in both north and south of my country and has rich plant resources. The main function of oriental tobacco is to flavor and season mixed cigarettes. In addition to making cigarettes for people to smoke, it also has medicinal values ​​such as anti-cancer, anti-tumor, anti-oxidation, anti-ultraviolet radiation, and liver protection. [0003] At present, there are not many studies on the chemical components of oriental tobacco. Foreign scholars have conducted in vitro antibacterial activity research on the essential oil extracts of ori...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D301/32C07D303/32A01N43/20A01P1/00
Inventor 徐俊驹周文兵何承刚李江舟彭梦洁张立猛杨海林孟玉芳卜令铎
Owner YUNNAN AGRICULTURAL UNIVERSITY
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