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Antibacterial hydrogel skin dressing preparation method

A hydrogel and skin technology is applied in the field of preparation of skin dressings, which can solve the problems of poor touch, single dressing performance, lack of protection of injured skin and promotion of repair, etc., and achieves easy preparation, reduction of scar degree, and restoration of skin shape and function. Effect

Inactive Publication Date: 2019-06-21
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional dressings have single performance, poor touch, and lack the functions of protecting injured skin and promoting repair

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment one: a kind of preparation method of antibacterial hydrogel type skin dressing comprises the following specific steps:

[0013] (1) Add polyvinyl alcohol into deionized water and dissolve it at a temperature of 80°C to obtain a polyvinyl alcohol solution with a mass concentration of 1%;

[0014] (2) Add chitosan salt to the above polyvinyl alcohol solution, dissolve at a temperature of 50°C, and control the mass concentration of the antibacterial agent in the solution to 0.5%;

[0015] (3) Cool the solution obtained in the above step (2) at room temperature, then add sodium hyaluronate to the solution, control the mass concentration of sodium hyaluronate in the solution to 3%, and Stir to dissolve all;

[0016] (4) Transfer the solution obtained in step (3) to a plate, freeze at -20°C for 5 hours, take it out and place it at room temperature for 10 hours, and obtain a hydrogel skin dressing with antibacterial effect.

Embodiment 2

[0017] Embodiment two: a kind of preparation method of antibacterial hydrogel type skin dressing comprises the following specific steps:

[0018] (1) Add polyvinyl alcohol into deionized water and dissolve it at a temperature of 90°C to obtain a polyvinyl alcohol solution with a mass concentration of 10%;

[0019] (2) Add the polymer quaternary ammonium salt into the above polyvinyl alcohol solution, dissolve it at a temperature of 80°C, and control the mass concentration of the antibacterial agent in the solution to 8%;

[0020] (3) Cool the solution obtained in the above step (2) at room temperature, then add sodium hyaluronate to the solution, control the mass concentration of sodium hyaluronate in the solution to 2%, and Stir to dissolve all;

[0021] (4) Transfer the solution obtained in step (3) to a plate, freeze at -20°C for 15 hours, take it out and place it at room temperature for 20 hours to obtain a hydrogel skin dressing with antibacterial effect.

Embodiment 3

[0022] Embodiment three: a kind of preparation method of antibacterial hydrogel type skin dressing comprises the following specific steps:

[0023] (1) Add polyvinyl alcohol into deionized water and dissolve it at a temperature of 100°C to obtain a polyvinyl alcohol solution with a mass concentration of 6%;

[0024] (2) Add the antibacterial peptide to the above polyvinyl alcohol solution, dissolve it at a temperature of 65°C, and control the mass concentration of the antibacterial agent in the solution to 4%;

[0025] (3) Cool the solution obtained in the above step (2) at room temperature, then add sodium hyaluronate to the solution, control the mass concentration of sodium hyaluronate in the solution to 1.5%, and Stir to dissolve all;

[0026] (4) Transfer the solution obtained in step (3) to a plate, freeze at -20°C for 11 hours, take it out and place it at room temperature for 15 hours to obtain a hydrogel skin dressing with antibacterial effect.

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PUM

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Abstract

The invention discloses an antibacterial hydrogel skin dressing preparation method. The method is characterized by including steps: adding polyvinyl alcohol into deionized water to obtain polyvinyl alcohol solution, adding an antibacterial agent into the polyvinyl alcohol solution, and controlling the mass concentration of the antibacterial agent in the solution to be 0.5-8%; then, cooling the solution at the room temperature, adding sodium hyaluronate into the solution, and stirring at the room temperature to dissolve completely; finally, transferring the obtained into a plate, freezing, taking out, and placing at the room temperature to obtain hydrogel skin dressing with an antibacterial effect. The hydrogel skin dressing has high antibacterial activity on gram positive bacteria and gramnegative bacteria, pains and secondary injuries caused by replacement of common dressing can be alleviated for patients, wound healing is promoted while pain alleviation is realized, scars are reduced, and a remarkable effect on skin function recovery is achieved.

Description

technical field [0001] The invention relates to the preparation of skin dressings in the medical field, in particular to a preparation method of an antibacterial hydrogel skin dressing. Background technique [0002] The skin is an important organ of the human body. It has the functions of protecting internal tissues from external damage, metabolism, regulating body temperature, feeling pain, pressure, temperature and cold stimulation, and immune surveillance. As the largest and most external organ of the human body, the skin is extremely vulnerable to trauma, such as: damage from external sharp objects, stimulation from chemical substances, diabetes, bedsores, venous ulcers, etc. The repair of skin wounds is divided into three stages: inflammatory response period, proliferative period and remodeling period. The inflammatory response period is the first emergency response of the human body to trauma, which determines whether or when the skin can enter the subsequent stage of ...

Claims

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Application Information

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IPC IPC(8): A61L26/00C08J3/075C08L29/04C08L5/08
Inventor 沈美婷王毓茜胡慧洁沈鑫炜吴徐金侯瑞霞牟贤波竺亚斌
Owner NINGBO UNIV
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