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Resin adsorption technology for extracting oligopyrrolidine carboxylic acid from ficus carica

A polypyrrolidine carboxylic acid and resin adsorption technology, which is applied in the direction of medical preparations containing active ingredients, plant raw materials, sensory diseases, etc., can solve problems such as no clear treatment purpose, and achieve convenient quality control, shortened production cycle, and environmental protection. non-polluting effect

Inactive Publication Date: 2019-05-28
雷萌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patents such as CN00121388.1 disclose a fig seed extract PCA strong anti-oxidation compound capsule and its manufacturing method, which is a compound health product with anti-aging and regulating body immune functions; CN02159540.2 uses fig seed extract as raw material Patents for capsules for anti-aging, anti-cancer, anti-oxidation, improving cardiovascular and cerebrovascular, etc., without specific therapeutic purposes
It can be seen that there is no patented invention that uses modern extraction technology and quality control methods to make fig waste residue into modern (standard extract) pharmaceutical preparations for preventing eye fatigue

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: A kind of resin adsorption technology that extracts oligopyrrolidine carboxylic acid from fig

[0025] The raw material is fig waste residue, which is extracted twice with 50% alcohol under reflux, and the dosage of each time is 7 to 5 times the weight of the original medicinal material, and the extraction time is 2 to 1 hour. The extracts are combined, filtered, alcohol is recovered, and concentrated to obtain the extract. Dilute the extract by 120 times with water, put it on a resin column for adsorption, the ratio of raw material weight to resin volume is 1:3, the ratio of resin column diameter to column height is 1:15, wash with pH=6 water, 50% alcohol solution The flow rate is 1 column volume / hour.

[0026] Collect the alcohol eluate, add a decolorizer according to 5% volume of the eluent, heat and reflux for 3 hours, filter, concentrate under reduced pressure, and dry in vacuum to obtain the product. Using this method, the PCA content in the fig was...

Embodiment 2

[0027] Embodiment 2: A kind of resin adsorption technology that extracts oligopyrrolidine carboxylic acid from fig

[0028] The raw material is fig waste residue, which is extracted 3 times with 60% alcohol under reflux, each dosage is 8, 6, and 4 times the weight of raw medicinal materials, and the extraction time is 60, 45, and 30 minutes. The extracts are combined, filtered, and the alcohol is recovered. paste. Dilute the extract by 150 times with water, and put it on a resin column for adsorption. The ratio of raw material weight to resin volume is 1:5, and the ratio of resin column diameter to column height is 1:20. Wash with pH=8 water and 60% alcohol solution. off at a flow rate of 2 column volumes / hour. The eluent was concentrated under reduced pressure and dried in vacuo to obtain the obtained product. Using this method, the PCA content in the fig waste residue can reach more than 50%.

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PUM

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Abstract

The invention provides a resin adsorption technology for extracting oligopyrrolidine carboxylic acid from ficus carica. A key point of a primary technology thereof is that content of an effective partof ficus carica seeds prepared by a ficus carica waste residue (ficus carica seeds, ficus carica peels and ficus carica stems or a mixture thereof) reaches 50% or more, wherein content of monomer effective component catechinic acid is within a range of 0.5-20% and the monomer effective component catechinic acid is used as a raw material for preparing a preparation. The technology is capable of preparing the preparation by using the effective part of the ficus carica seeds obtained by using the ficus carica waste residue as the raw material, wherein cost is low, and the technology is simple and rational, keeping an original structure and activity of the effective part, wherein an extract of the ficus carica seeds can be prepared as any medical and health-care product drug forms for preventing and treating eyestrain, and the technology is applied to the medical treatment and health-care fields of preventing and treating the eyestrain.

Description

technical field [0001] The invention relates to a plant extract, preparation and preparation method, in particular to a resin adsorption technology for extracting oligopyrrolidine carboxylic acid from figs. Background technique [0002] Oligomeric Proanthocyanidins (PCA) rich in figs is a polyphenolic substance composed of catechin monomers, dimers, and trimers. As early as the 1970s, French scientists discovered that fig seeds are the best resource for extracting pyrrolidine carboxylic acid, and the content of proanthocyanidins in its extract can be as high as 95%. my country is rich in fig resources, and only about 8000t of fig waste residue is left over after brewing fig wine every year, and the planting area of ​​figs is still increasing a lot in recent years, but it is only used as a simple extraction of fig seed oil, feed, Fertilizers and polyphenol raw materials. Studies have found that PCA has significant antioxidant properties (its antioxidant capacity is V C 20 t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60C07D311/62A61K31/353A61P27/02A61P37/04A61P39/06
Inventor 雷萌
Owner 雷萌
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