Preparation method of capillary tube SERS substrate and SERS capillary tube

A capillary and substrate technology, applied in the field of SERS capillary, can solve the problems of cumbersome, non-uniform excitation light focusing, and reduce the detection effect of SERS, and achieve the effect of uniform signal collection, high excitation efficiency, and effective focusing

Pending Publication Date: 2019-05-21
FUJIAN NORMAL UNIV
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AI Technical Summary

Problems solved by technology

[0005] The preparation process of the existing capillary SERS substrate (that is, the process of depositing silver nanoparticles on the inner wall of the capillary) is cumbersome, and the existing capillary SERS substrate is a conventional circular structure capillary. When the signal is collected, the circular structure easily leads to misfocusing of the excitation light Uniformity, thereby increasing the interference of the substrate background signal; in addition, when a certain thickness of nanoparticles is deposited on the inner wall of the capillary, it is easy to hinder the effective penetration and excitation of the excitation light, thereby reducing the SERS detection effect

Method used

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  • Preparation method of capillary tube SERS substrate and SERS capillary tube
  • Preparation method of capillary tube SERS substrate and SERS capillary tube
  • Preparation method of capillary tube SERS substrate and SERS capillary tube

Examples

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Effect test

Embodiment 1

[0029] see figure 1 , the preparation method of capillary SERS substrate, comprises the steps:

[0030] (1) Preparation of metal nanoparticle ink mother liquor: add 1mL of isopropanol solution with a mass fraction of 70% to the metal nanoparticle conductive slurry, and ultrasonically 15min under darkroom conditions to obtain metal nanoparticle ink mother liquor; wherein, metal nanoparticle The volume ratio of particle conductive slurry to isopropanol is 1:1; the mother liquid of metal nanoparticle ink is preferably silver.

[0031] (2) Preparation of nanoparticle precursor ink: Dilute silver metal nanoparticle ink mother liquor with 70% isopropanol solution to obtain nanoparticle precursor ink; wherein, the volume ratio of metal nanoparticle conductive slurry to isopropanol is 1: 1.

[0032] (3) Nanoparticle attachment: Soak the polygonal capillary in the nanoparticle precursor ink, and keep soaking for 5 minutes, absorb the remaining nanoparticle precursor ink in the polygo...

Embodiment 2

[0034] This part differs from Example 1 in that:

[0035] (2) Dilute the silver ink mother solution with 70% isopropanol solution to obtain a silver ink solution, wherein the volume ratio of metal nanoparticle conductive slurry to isopropanol is 1:32.

[0036] (3) Use the capillary effect to soak the rectangular capillary in silver ink for 30 minutes, absorb the remaining silver ink in the polygonal capillary, quickly place the capillary on a preheated heating platform at 135°C, and heat for 10 minutes.

Embodiment 3

[0038] This part differs from Example 1 in that:

[0039] (2) Dilute the silver ink mother solution with 70% isopropanol solution to obtain a silver ink solution, wherein the volume ratio of metal nanoparticle conductive paste to isopropanol is 1:15.

[0040] (3) Use the capillary effect to soak the hexagonal capillary in silver ink for 16 minutes, absorb the remaining silver ink in the polygonal capillary, quickly place the capillary on a preheated 135°C heating platform, and heat for 7 minutes.

[0041] The cross-sectional view of the prepared SERS capillary 100 is as follows figure 2 As shown, the SEM image of the inner wall of the SERS capillary 100 is as follows image 3 shown. By measuring the concentration of 10 -4 M's rhodamine 6G solution, to evaluate the reproducibility of the measurement results of the SERS capillary 100 prepared in different batches using the spectral peak 1510cm -1 Intensity calculation relative standard deviation, the result is 15%, showing ...

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Abstract

The invention provides a preparation method of a capillary tube SERS substrate and an SERS capillary tube. The preparation method comprises: a 1-mL isopropanol solution with the mass fraction of 70% is added into a metal nanoparticle conductive slurry and ultrasonic processing is carried out under a a dark room condition for 15min to obtain a silver metal nanoparticle ink mother solution; the silver metal nanoparticle ink mother solution is diluted by using 70% of isopropanol solution to obtain nanoparticle precursor ink; and a polygonal capillary tube is immersed into the nanoparticle precursor ink for 5 to 30min, residual nanoparticle precursor ink in the polygonal capillary tube is removed, one side of the polygonal capillary is quickly placed on a preheated heating platform at a temperature of 135 DEG C and suface contact with the heating platform is kept, and cooling is carried out and then an SERS capillary tube is obtained. According to the SERS capillary tube, the flat laser irradiation can be obtained and effective focusing and uniform signal acquisition are realized; and the capillary tube has advantages of higher excitation efficiency and simple and rapid operation.

Description

【Technical field】 [0001] The invention specifically relates to a preparation method of a capillary SERS substrate and a SERS capillary. 【Background technique】 [0002] Compared with conventional Raman technology, surface-enhanced Raman spectroscopy (SERS) has the advantages of high sensitivity, which makes it widely used in various research and analysis fields; one of the most interesting applications of SERS is the detection of non-labeled biomolecules . SERS has been successfully used to detect various biomolecules (such as proteins, nucleic acids and biological metabolites, etc.), as well as the interaction between biomolecules; and saliva), combined with efficient statistical analysis methods, is expected to provide a new method for early non-destructive diagnosis of diseases. [0003] However, conventional SERS detection is basically carried out in a dry state, which easily causes photothermal damage to material molecules, and cannot obtain structural and functional i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
Inventor 黄祖芳黄伟梁晓周冯尚源林居强李永增
Owner FUJIAN NORMAL UNIV
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