Ultrasonic real-time monitoring method of tumor photo-thermal treatment range

Abstract

The invention relates to the technical field of monitoring in tumor treatment, and discloses an ultrasonic real-time monitoring method of a tumor photo-thermal treatment range. The method includes thestep of monitoring and further includes the step of data quantifying and evaluating. In the step of monitoring, specifically, the tissue hardness of a focus region and surrounding normal tissue is monitored in real time through ultrasonic waves, and a two-dimensional tissue hardness distribution image is output in real time. In the step of data quantifying and evaluating, the output image is quantified and evaluated at intervals according to the two-dimensional tissue hardness distribution image output in real time, and the intensity and the range of photo-thermal treatment are recognized. The tissue hardness is used as a monitoring object, the hardness change of the focus region and the surrounding normal tissue is monitored in real time through the ultrasonic waves, the temperature andhardness change of lesion tissue and normal tissue is acquired, thus, the temperature and hardness change condition of the tissue can be found effectively in time, the power and the duration of near infrared light can be adjusted in time, and then the problem of iatrogenic injuries of the normal tissue is effectively avoided.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to an ultrasound real-time monitoring method for the photothermal treatment range of tumors. Background technique [0002] Photothermal therapy technology is a kind of thermal ablation therapy technology. Its working principle is to use materials with high photothermal conversion efficiency and inject them into the interior of organisms, and use targeted recognition technology to make materials in tumor tissue and It is concentrated near the tumor tissue, and under the irradiation of an external light source (usually near-infrared light), the light energy is converted into heat energy to kill tumor cells. In order to achieve the purpose of treatment, it is often necessary to raise the temperature of the treatment area to above 55°C during photothermal therapy to denature proteins to kill cancerous cells. During this process, the normal tissues around the diseased tissue often caus...

AI Technical Summary

Problems solved by technology

[0004] (1) Use infrared thermal imaging equipment for monitoring, which has the advantages of easy operation, real-time detection, and the change of tissue temperature can be seen intuitively, but the disadvantages are: first, the measurement of the treatment target area by the infrared thermal imaging camera, the result is tissue Two-dimensional images of surface temperature, but the temperature inside the tissue cannot be directly measured, so the temperature change inside the tissue cannot be effectively monitored; second, the boundary between the diseased tissue and the treatment target tissue cannot be accurately determined, and it cannot be detected in time Thermal damage to normal tissue, so it cannot solve the problem of thermal damage to normal tissue

[0005] (2) Using a probe thermometer for monitoring has the advantage of accurate temperature monitoring and easy temperature control, but the disadvantage is that because the measurement method is contact measurement, the probe can only measure the temperature that touches the local tissue, and cannot The area outside the measurement point is measured, so the overall temperature change of the tissue cannot be effectively monitored

However, these new imaging technologies are not yet very mature, and there are problems with poor resolution and other parameters, and their theory is not perfect, and they have not been widely used clinically.

[0009] At present, there is no material or method that takes into account all the above advantages. Therefore, in photothermal therapy, while ensuring that the treatment intensity is sufficient to achieve the purpose of treatment, we hope to find a simple, safe and cheap method to effectively prevent iatrogenic heat injury

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