A nerve repair membrane and its preparation method and application

A nerve repair and fiber membrane technology, applied in medical science, prosthesis, coating, etc., can solve the problems of disordered growth of nerve cells and unfavorable nerve repair, so as to improve growth rate and synapse morphology, and promote orientation Growth, growth improvement effect of nerve axon

Active Publication Date: 2022-06-03
宁波光远致信生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The nerve guide prepared by the above method has high mechanical strength, strong flexibility, and long degradation cycle, and can be well applied to the regeneration and repair of damaged nerves, but the nerve guide used to repair damaged nerves During the process, nerve cells grow disorderly, which is not conducive to the repair of nerves.

Method used

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  • A nerve repair membrane and its preparation method and application
  • A nerve repair membrane and its preparation method and application
  • A nerve repair membrane and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] The carbon nanotube-incorporated polymer fiber membrane was sterilized by irradiating with ultraviolet light for 5 h, followed by phosphate buffering.

Embodiment 2

[0080] The difference with Embodiment 1 is that step (3) is not performed.

Embodiment 3

[0082] The difference from Example 1 is that polylactic acid-glycolic acid copolymer is replaced by polylactic acid (Mw=80000).

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Abstract

The invention relates to a nerve repair membrane and its preparation method and application. The nerve repair membrane includes a polymer fiber membrane doped with carbon nanotubes; the polymer is a biodegradable polymer; the doped carbon nanotube The polymer fiber film has a single orientation. The method comprises the following steps: (1) dissolving the polymer and the carbon nanotubes in a solvent to obtain an electrospinning stock solution; (2) performing an electrospinning operation on the electrospinning stock solution to obtain a polymeric substance doped with carbon nanotubes. The fibrous membrane is the nerve repair membrane. The nerve repair membrane provided by the invention can promote the directional growth of nerve cells, and has an excellent repair effect on damaged nerves.

Description

A kind of nerve repair membrane and its preparation method and application technical field The present invention relates to technical field of biomedical materials, be specifically related to a kind of nerve repair membrane and preparation method thereof and use way. Background technique [0002] Peripheral nerve injury is a common disabling condition that results in loss of sensation and motor dysfunction hinder. Various approaches have been applied in clinical therapy today to restore loss of function. End-to-end splicing can be used for short nerves Injury, while performing a remote nerve defect requires a nerve graft to bridge the transected nerve. Currently, nerve autografting is the treatment A 5-10mm gap is the clinical criterion for peripheral nerve injury, however this approach requires removal of a segment of the nerve from a secondary part of the body This can lead to additional surgical pain, as well as loss of sensory function at the donor site. In a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/50A61L27/08A61L27/34A61L27/18A61F2/02
Inventor 许杉杉韩志超张诺滋
Owner 宁波光远致信生物科技有限公司
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