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Janus magnetic imprinted nanosheet, preparation method and application thereof

A magnetic molecular imprinting, nanosheet technology, applied in chemical instruments and methods, other chemical processes, alkali metal oxides/hydroxides, etc., can solve the overlapping of functional sites and regions, poor separation effect, low selectivity, etc. problem, to achieve the effect of improving specific identification, large adsorption capacity and good selectivity

Active Publication Date: 2019-05-07
江苏艾科姆检测有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve one of the technical bottlenecks existing in existing MMIPs composite adsorbents, such as overlapping functional sites and regions, low selectivity, and poor separation effect, the present invention provides a method for preparing a Janus-type magnetically imprinted nanosheet adsorbent, and Selective separation of dA achieved

Method used

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  • Janus magnetic imprinted nanosheet, preparation method and application thereof
  • Janus magnetic imprinted nanosheet, preparation method and application thereof
  • Janus magnetic imprinted nanosheet, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) Carboxy-modified Fe 3 o 4 Granule preparation

[0041] Mix 100 mL of 0.2 mol / L sodium oleate aqueous solution with 100 mL of 0.2 mol / L ferric chloride aqueous solution. The brown iron oleate complex was obtained by filtration, dispersed with n-hexane, washed three times with distilled water, and dried in a desiccator. Add the complex to 20.0 mL of ethanol containing 10% oleic acid at room temperature. The mixture was transferred to an autoclave and heated to 180 °C for 5 hours. After the reaction, the black oleic acid-capped Fe was washed with ethanol 3 o 4 Nanoparticles (Fe 3 o 4 NPs) and separated with a magnet. The product was redispersed in toluene at a concentration of 10 mg / mL.

[0042] (2) Preparation of Janus nanosheets

[0043] A certain amount of 10 wt% HSMA and water were used as the continuous phase in a beaker, and the pH was adjusted to 3-4 with 2 mol / L HCl solution. Take a certain amount of solid paraffin, add a certain amount of 3-aminopro...

Embodiment 2

[0054] (1) Carboxy-modified Fe 3 o 4 Granule preparation

[0055] Mix 100 mL of 0.2 mol / L sodium oleate aqueous solution with 150 mL of 0.2 mol / L ferric chloride aqueous solution. The brown iron oleate complex was obtained by filtration, dispersed with n-hexane, washed three times with distilled water, and dried in a desiccator. Add the complex to 20.0 mL of ethanol containing 12.5% ​​oleic acid at room temperature. The mixture was transferred to an autoclave and heated to 180 °C for 5 hours. After the reaction, the black oleic acid-capped Fe was washed with ethanol 3 o 4 Nanoparticles (Fe 3 o 4 NPs) and separated with a magnet. The product was redispersed in toluene at a concentration of 10 mg / mL.

[0056] (2) Preparation of Janus nanosheets

[0057] A certain amount of 10 wt% HSMA and water were used as the continuous phase in a beaker, and the pH was adjusted to 3-4 with 2 mol / L HCl solution. Take a certain amount of solid paraffin, add a certain amount of 3-amin...

Embodiment 3

[0063] (1) Carboxy-modified Fe 3 o 4 Granule preparation

[0064] Mix 100 mL of 0.2 mol / L sodium oleate aqueous solution with 200 mL of 0.2 mol / L ferric chloride aqueous solution. The brown iron oleate complex was obtained by filtration, dispersed with n-hexane, washed three times with distilled water, and dried in a desiccator. Add the complex to 20.0 mL of ethanol containing 15% oleic acid at room temperature. The mixture was transferred to an autoclave and heated to 180 °C for 5 hours. After the reaction, the black oleic acid-capped Fe was washed with ethanol 3 o 4 Nanoparticles (Fe 3 o 4 NPs) and were separated by a magnet. The product was redispersed in toluene at a concentration of 10 mg / mL.

[0065] (2) Preparation of Janus nanosheets

[0066] A certain amount of 10 wt % HSMA and water were used as the continuous phase in a beaker, and the pH was adjusted to 3-4 with 2 mol / L HCl solution. Take a certain amount of solid paraffin, add a certain amount of 3-amin...

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Abstract

Belonging to the technical field of functional materials, the invention relates to a Janus magnetic molecularly imprinted nanosheet, a preparation method and application thereof. The method includes:preparing Janus hollow microspheres by sol-gel method, and conducting ultrasonic breaking to obtain a Janus nanosheet containing amino on one side and containing chlorine element on the other side; then taking surface chlorine element as the initiator of atom transfer radical polymerization, adopting dA as the template molecule, using 5-(2-methoxy vinyl)-2'-deoxyuridine as the functional monomer,and grafting a dA molecularly imprinted polymer to the hydrophobic surface of the Janus nanosheet; and then combining oleic acid coated Fe3O4 particles to the hydrophobic surface of Janus through thebonding effect between amino and carboxyl to prepare a Janus magnetic molecularly imprinted nanosheet adsorbent, and applying the obtained material to adsorption and separation of dA. The imprinted adsorption material constructed by the invention has the advantages of good selectivity, large adsorptive capacity to target dA and rapid separation.

Description

technical field [0001] The invention relates to a Janus type magnetic molecular imprinted nanosheet and a preparation method and application thereof, belonging to the technical field of functional materials. Background technique [0002] 2'-Deoxyadenosine (dA), as one of the purine nucleosides with good physiological activity, is an important raw material for gene medicine and genetic engineering research. In addition, dA has good physiological activity and is recognized as a good intermediate of many antiviral, antitumor and anti-AIDS drugs, so it has an extremely wide demand in the market. At present, common dA acquisition methods include synthesis, crystallization and adsorption, but the synthesis method has many by-products and the concentration of the product is low; the crystallization method consumes a lot of energy and has a slow formation rate; The advantages of high extraction rate and easy continuous operation, but the selectivity, adsorption capacity and mass tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30
Inventor 王盼刘金鑫潘建明
Owner 江苏艾科姆检测有限公司
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