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Antibacterial cellulose filament for wound repair and preparation method thereof

A cellulose filament and wound repair technology, applied in the direction of rayon filament made of cellulose derivatives, rayon manufacturing, fiber chemical characteristics, etc., can solve problems such as inapplicability, toxicity, pollution, etc., to avoid wounds Infection, improving solubility, reducing toxicity

Active Publication Date: 2021-09-21
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The antibacterial agents used in the existing cellulose antibacterial modification all have certain pollution or toxicity. For example, the commonly used nano silver has excellent antibacterial effect, and the smaller the particle size, the better the antibacterial effect, but when the particle size is small, it is easy to Escaping silver ions, which are cytotoxic, not suitable for wound repair materials

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] In the first step, cellulose and methionine are mixed, and then heated for 15 minutes for 120 minutes to obtain the reaction product; in the second step, the reaction product obtained in the first step is directly dissolved in the prepared alkali / urea / sodium zincate water solvent , the dissolution temperature is -5°C, then add silver nitrate and chloroauric acid to the dissolved solution in turn, and let it stand at 20°C for 12 hours, wherein the time interval between adding silver nitrate and chloroauric acid is 12 hours, nitric acid The molar ratio of silver and chloroauric acid added is 10:1; in the third step, the solution finally obtained in the second step is spun on an R535A spinning machine to obtain antibacterial cellulose filaments for wound repair. The coagulation of the spinning machine adopts a multi-stage coagulation bath, the first-level coagulation bath uses an aqueous solution of ethylene glycol, the second-level coagulation bath uses 0.1 wt% potassium h...

Embodiment 2

[0023] The first step is to mix cellulose and lysine, and then heat the reaction at 170 ℃ for 10 minutes to obtain the reaction product; the second step is to directly dissolve the reaction product obtained in the first step in the prepared alkali / urea / sodium zincate water solvent , the dissolution temperature is 3°C, then add silver nitrate and chloroauric acid to the dissolved solution in turn, and let it stand at 5°C for 10 hours, wherein the time interval between the addition of silver nitrate and chloroauric acid is 24 hours, silver nitrate The ratio of the molar amount added to chloroauric acid is 25:1; in the third step, the solution finally obtained in the second step is spun on an R535A spinning machine to obtain antibacterial cellulose filaments for wound repair. The coagulation of the spinning machine adopts a multi-stage coagulation bath, the first-level coagulation bath uses an aqueous solution of ethylene glycol, the second-level coagulation bath uses 0.2 wt% pota...

Embodiment 3

[0026] The first step is to mix cellulose, leucine and tryptophan, and then heat the reaction at 180 ℃ for 80 minutes to obtain the reaction product; the second step is to directly dissolve the reaction product obtained in the first step in the prepared alkali / urea / water solvent , the dissolution temperature is -4°C, and then silver nitrate and chloroauric acid are added to the dissolved solution in turn, and left to stand at 5°C for 18 hours, wherein the time interval between the addition of silver nitrate and chloroauric acid is 12 hours, The molar ratio of silver nitrate and chloroauric acid added is 50:1; in the third step, the solution finally obtained in the second step is spun on an R535A spinning machine to obtain antibacterial cellulose filaments for wound repair. The coagulation of the spinning machine adopts a multi-stage coagulation bath, the first-level coagulation bath uses an aqueous solution of ethylene glycol, the second-level coagulation bath uses 0.1 wt% pota...

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Abstract

The invention discloses an antibacterial cellulose filament for wound repair and a preparation method thereof, wherein the filament matrix is ​​amino acid esterified cellulose, and also contains gold-shell silver-core nano-alloy particles and nano-ZnO particles, wherein the nano-alloy and ZnO particles have a heterogeneous structure. The preparation method is divided into the steps of cellulose derivatization, dissolution, biological reduction and mineralization, and wet spinning. The method can avoid the toxicity of silver ions, improve the bactericidal rate through rich interfacial interactions, and prevent wound infection; in addition, the release of active factors is beneficial to wound repair.

Description

technical field [0001] The invention relates to an antibacterial cellulose filament for wound repair and a preparation method thereof, which belong to the fields of textile and hygiene. Background technique [0002] Research on new antibacterial materials or antibacterial drugs has always been a hot topic. In particular, in the face of the challenges brought about by superbug resistance and other issues, the research and development of new antibacterial materials and antibacterial drugs is still very necessary and urgent. As the most abundant biomass resource on earth, cellulose has been integrated into human life and is closely related to it since ancient times. For example, cellulose fabrics (about 18.85 million tons / year) and their paper products (such as facial tissues, diapers, banknotes, etc.) favored and widely used. However, the good adsorption of cellulose products to human sweat, sebum and surface debris makes it a breeding ground for bacteria, fungi and other i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/44A61L15/46D01F2/28D01F1/10
CPCA61L15/18A61L15/28A61L15/44A61L15/46A61L2300/102A61L2300/104A61L2300/404A61L2300/624D01F1/103D01F2/28C08L1/02
Inventor 张瑞鸿付飞亚唐海跃刘向东
Owner ZHEJIANG SCI-TECH UNIV
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