Application of novel gastric cancer marker gene circPTPDC1

Abstract

The invention discloses the application of a novel gastric cancer marker gene circPTPDC1, and relates to the discovery, detection and application of a circPTPDC1 molecular marker. A specific detectingprimer which is used for quantifying PCR in real time is designed and synthesized. The marker gene is provided aiming at the problems that the compliance of target crowds on gastric cancer endoscopicscreening is poor and gastric cancer patients are mostly and clinically diagnosed according to middle and late current situations, an ideal molecular early warning signal is found in the cancerationprocess of the gastric cancer, endoscopic inspection is targetedly conducted, athological diagnosis is conducted to relieve the pain of a patient, and over-treatment is conducted to save medical resources. According to the application, it is discovered that blood circPTPDC1 can be adopted as a marker of lymph node metastasis and monitoring prognosis of the gastric patients.

Description

technical field [0001] The invention relates to the field of tumor molecular biology, in particular to the application of a novel gastric cancer marker gene circPTPDC1. Background technique [0002] At present, gastric cancer still ranks third in cancer-related deaths worldwide and is one of the major health burdens of society. Gastric cancer is the second most prevalent cancer and the second leading cause of cancer death in China, with an estimated 679,100 new cases and 498,000 deaths in 2015. Despite advances in surgical techniques and combined chemotherapy regimens, the 5-year overall survival of gastric cancer is still below 30% in most countries because of the lack of early diagnostic markers for gastric cancer. Therefore, it is necessary to carefully explore gastric cancer-related molecular features and develop reasonable methods for early detection of gastric cancer. [0003] Circular RNAs (circRNAs), thought to arise from non-canonical splicing of linear pre-mRNAs,...

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Problems solved by technology

[0005] In order to solve the above problems, the present invention discloses the application of a new gastric cancer marker gene circPTPDC1, aiming at the poor compliance of the target population with endoscopic screening for gastric cancer and the fact that most of the clinically diagnosed gastric cancer patients are in the middle and late stages, Find the ideal molecular early warning signal in the process of gastric cancer carcinogenesis, carry out targeted endoscopic examination, and make a pathological diagnosis, so as to alleviate the suffering of patients, avoid excessive medical treatment, and save medical resources

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