Mucosal administration medicament for promoting postoperative healing of palate mucosa and application thereof

A mucosal drug delivery and drug technology, applied in the field of medicine, can solve the problems of low correlation in drug research, unfavorable mucosal repair, and lack of in-depth research on the mechanism of action.

Inactive Publication Date: 2019-04-23
张园园
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the research relevance of related drugs is not high
It has been proved that mitomycin C can promote mucosal healing within a certain concentration range, but it is not conducive to mucosal repair at higher concentrations.
Organic acids such as humic acid, dimethyloxalylglycine, and caffeic acidphenethyl ester can promote the healing of oral soft tissues such as palatal mucosa, but the mechanism of action has not been studied in depth

Method used

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  • Mucosal administration medicament for promoting postoperative healing of palate mucosa and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] Example 1 Drugs Administered to Mucosal Stimulation of Postoperative Palatal Mucosa Healing

[0089] Tannic acid 4g

[0090] Polyvinyl alcohol 8g

[0091] Sodium Carboxymethyl Cellulose 5g

[0092] Ethylcellulose 5g

[0093] Propylene glycol 16g

[0094] Glycerin 4g

[0095] Ethanol 200g

[0096] Distilled water 500g

[0097] Preparation:

[0098] (1) Dissolve the prescribed amount of ethyl cellulose in the prescribed amount of ethanol, pour the resulting solution on a glass plate coated with liquid paraffin, and dry it as a protective film.

[0099] (2) Take the prescribed amount of polyvinyl alcohol and sodium carboxymethyl cellulose, add distilled water to soak and swell, and then mix the obtained solutions;

[0100] (3) Take the prescribed amount of glycerin, propylene glycol and 40g of water, mix them, add the prescribed amount of tannic acid, mix well, and then add the solution obtained in step (2).

[0101] (4) Add the rest of the distilled water to the ...

Embodiment 2

[0102] Example 2 Drugs Administered to the Mucosa for Promoting Postoperative Palatal Mucosa Healing

[0103] Tannic acid 1g

[0104] Cixi Ophiopogon saponin A 3g

[0105] Polyvinyl alcohol 8g

[0106] Sodium Carboxymethyl Cellulose 5g

[0107] Ethylcellulose 5g

[0108] Propylene glycol 20g

[0109] Glycerin 8g

[0110] Ethanol 200g

[0111] Distilled water 500g

[0112] Preparation:

[0113] Preparation:

[0114] (1) Dissolve the prescribed amount of ethyl cellulose in the prescribed amount of ethanol, pour the resulting solution on a glass plate coated with liquid paraffin, and dry it as a protective film.

[0115] (2) Take the prescribed amount of polyvinyl alcohol and sodium carboxymethyl cellulose, add distilled water to soak and swell, and then mix the obtained solutions;

[0116] (3) Take the prescribed amount of glycerin, propylene glycol and 60g of water, mix them, add the prescribed amount of tannic acid, and Cixi Ophiopogon saponin A, stir evenly, and the...

Embodiment 3

[0118] Example 3 Drugs Administered to the Mucosa for Promoting Postoperative Palatal Mucosa Healing

[0119] Tannic acid 1g

[0120] Cixi Ophiopogon saponin A 4g

[0121] Polyvinyl alcohol 8g

[0122] Sodium Carboxymethyl Cellulose 5g

[0123] Ethylcellulose 5g

[0124] Propylene glycol 20g

[0125] Glycerin 8g

[0126] Ethanol 200g

[0127] Distilled water 500g

[0128] Preparation:

[0129] Preparation:

[0130] (1) Dissolve the prescribed amount of ethyl cellulose in the prescribed amount of ethanol, pour the resulting solution on a glass plate coated with liquid paraffin, and dry it as a protective film.

[0131] (2) Take the prescribed amount of polyvinyl alcohol and sodium carboxymethyl cellulose, add distilled water to soak and swell, and then mix the obtained solutions;

[0132] (3) Take the prescribed amount of glycerin, propylene glycol and 80g of water, mix them, add the prescribed amount of tannic acid, and Cixi ophiopogon saponin A, stir evenly, and the...

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Abstract

The invention belongs to the field of medicaments, and particularly relates to a mucosal administration medicament for promoting postoperative healing of palate mucosa and application thereof. The mucosal administration medicament for promoting postoperative healing of palatal mucosa can be a preparation for transmucosal local administration such as a gel for mucosal administration or a mucosal patch preparation. The active ingredient of the mucosal administration mendicant is tannic acid, and cixi ophiopogon root saponin A can also be added, wherein the ratio of the tannic acid to the cixi ophiopogon root saponin A is 1:3-5. The mucosal administration medicament has an effect of promoting the healing of the postoperative palatal mucosa, and the local administration of the tannic acid andcixi ophiopogon root saponin A on the mucosal injury part has a better effect of promoting the healing of the postoperative palatal mucosa.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a mucosal drug for promoting postoperative healing of palatal mucosa and use thereof. Background technique [0002] Oral and maxillofacial surgery mainly involves the surgical manipulation of the oral and maxillofacial bones and soft tissues. No matter the surgical operation on the oral and maxillofacial bones or soft tissues, it is inevitable to damage the oral mucosal system, such as the mucosa of the lips, tongue, gums, and jaws. A typical example: The mucous membrane covering the upper jaw is firm and elastic, and fits tightly to the bone through the periosteum, which may aid in food manipulation. Surgical closure of a cleft palate results in partial detachment of the mucosa, resulting in mucosal damage that interferes with feeding. [0003] The fundamental role of mucosal healing is to restore tissue integrity and tissue function. In the healing process of soft tissues...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/38A61K47/32A61K47/10A61K31/7048A61K31/7024A61P1/02
CPCA61K9/006A61K9/7007A61K31/7024A61K31/7048A61K47/10A61K47/32A61K47/38A61P1/02A61K2300/00
Inventor 张园园邱艳梅张宁
Owner 张园园
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