Swainsonin antigen and preparation method thereof

A swainsonine and antigen technology, which is applied to the field of swainsonine antigen and its preparation, can solve the problems of economic loss in animal husbandry production, not being effectively controlled, affecting growth and reproduction, etc. The effect of high connection ratio

Active Publication Date: 2019-04-19
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chronic poisoning caused by animals eating locoweeds affects growth and reproduction, and even dies, causing huge economic losses to animal husbandry production, which has not been effectively controlled so far

Method used

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  • Swainsonin antigen and preparation method thereof
  • Swainsonin antigen and preparation method thereof
  • Swainsonin antigen and preparation method thereof

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Embodiment Construction

[0016] The preferred embodiments of the present invention will be described below in conjunction with the accompanying drawings. It should be understood that the preferred embodiments described here are only used to illustrate and explain the present invention, and are not intended to limit the present invention.

[0017] Example 1 Preparation method of swainsonine antigen

[0018] 1.1 Materials and methods

[0019] 1.1.1 Main materials

[0020] Swainsonine (SW) was provided by the Drug Research Laboratory of Lanzhou Institute of Animal Husbandry and Veterinary Medicine, Chinese Academy of Agricultural Sciences. Monoethyl glutaric acid chloride, Bailingwei Technology Co., Ltd. Bovine Serum Albumin (BSA), Runde Biological Products. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC.HCl): Shandong West Asia Chemical Industry Co., Ltd., Hydroxybenzotriazole (HOBt): Shanghai Yantuo Biology Technology Co., Ltd., dialysis bag (3500) imported from the United States:...

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Abstract

The invention discloses a swainsonin antigen. The swainsonin antigen has a following chemical structural formula shown in the description, wherein BSA is bovine serum albumin. The preparation method of the swainsonin antigen comprises the steps that (1) swainsonin and ethyl malonyl chloride are subjected to a reaction to obtain a compound I shown in the description, the compound I is dechlorinatedunder the alkali function and acidified to obtain a compound II shown in the description, and the compound II and BSA are condensed to obtain the swainsonin antigen under the function of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 1-hydroxybenzotriazole. The synthesis process of the swainsonin antigen is simple, easy to operate, low in cost and high in coupling ratio, the antigen can produce high-titer antibodies, and a new way is opened for the reasonable development and utilization of locoweed plants.

Description

technical field [0001] The invention relates to a swainsonine antigen and a preparation method thereof. Background technique [0002] Locoweed is the most serious poisonous plant in many areas such as western my country, mainly including poisonous plants of the genus Astragalus and Oxytropis in leguminous plants, which have a large area in my country and many other countries in the world distributed. Animals eating locoweeds cause chronic poisoning, affect growth and reproduction, and even die, causing huge economic losses to animal husbandry production, which have not been effectively controlled so far. However, in addition to toxic components, locoweed also contains a large amount of nutrients such as protein and trace elements; at the same time, locoweed has a well-developed root system and strong stress resistance. Conducive to the development of grassland animal husbandry. In addition, studies have also proved that locoweed has immune regulation function and can inhib...

Claims

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Application Information

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IPC IPC(8): C07K14/765
CPCC07K14/765C07K19/00
Inventor 梁剑平刘宇梁妍王宝海郝宝成王学红刘建枝王金龙夏晨阳郭文柱赵凤舞陶蕾贾忠张新刚
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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