A kind of preparation method of sucrose oleate with high monoester content

A technology of sucrose oleate and high monoester, which is applied to the preparation of sugar derivatives, esterified saccharides, chemical instruments and methods, etc., which can solve the problems of unfriendly production, poor selectivity of catalytic reaction, and deep color of products

Active Publication Date: 2020-07-28
京山瑞生制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method requires conditions such as high temperature and high pressure, the selectivity of the catalytic reaction is poor, the product is dark in color, and is accompanied by the formation of various by-products, which does not meet the requirements of environmentally friendly production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) In the reaction kettle, add pyridine (752g), add sucrose powder raw material (376g, 1.1mol), add ZIF-67 (3g), start stirring and mixing.

[0023] (2) After removing water and oxygen from the reaction system, methyl oleate (300 g, 1 mol) was slowly added at a reaction temperature of 50° C., and at the same time methanol was continuously distilled off to promote the reaction. The reaction time was 6 hours.

[0024] (3) After the reaction, add saturated brine to wash, and let stand to separate layers. Vacuum drying under reduced pressure at 70°C to obtain the product sucrose oleate. Its monoester content is 97.5%, and the yield is 90.7%.

Embodiment 2

[0026] (1) In the reaction kettle, add piperidine (513g), add sucrose powder raw material (513g, 1.5mol), add ZIF-67 (0.3g), start stirring and mixing.

[0027] (2) After removing water and oxygen from the reaction system, methyl oleate (300 g, 1 mol) was slowly added at a reaction temperature of 90° C., and at the same time methanol was continuously distilled off to promote the reaction. The reaction time was 3 hours.

[0028] (3) After the reaction, add saturated brine to wash, and let stand to separate layers. Vacuum drying under reduced pressure at 70°C to obtain the product sucrose oleate. Its monoester content is 95.8%, and the yield is 91.8%.

Embodiment 3

[0030] (1) In the reaction kettle, add pyridine (666g), add sucrose powder raw material (444g, 1.3mol), add ZIF-67 (1.0g), start stirring and mixing.

[0031] (2) After removing water and oxygen from the reaction system, methyl oleate (300 g, 1 mol) was slowly added at a reaction temperature of 70° C., and at the same time, methanol was continuously distilled off to promote the reaction. The reaction time was 4 hours.

[0032] (3) After the reaction, add saturated brine to wash, and let stand to separate layers. Vacuum drying under reduced pressure at 70°C to obtain the product sucrose oleate. Its monoester content is 96.1%, and the yield is 91.0%.

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Abstract

The invention discloses a preparation method of sucrose oleate high in monoester content. The method includes the following steps that an alkaline solvent medium is added in a reaction kettle, sucrosepowder raw materials are added, a catalyst is added, and stirring and mixing are performed; after a reaction system is subjected to dewatering and deoxygenization, methyl oleate is slowly added at reaction temperature, and methanol is removed through steaming continuously. ZIF-67 of a metal organic skeleton complex serves as a catalyst having an excellent catalytic esterification effect on the reaction system, and especially the product high in monoester content is obtained. An alkaline solvent medium is adopted, can dissolve sucrose, has a remarkable promotion effect on the reaction, can greatly enhance the selectivity and conversion rate of a sucrose oleate reaction, increases the reaction rate and the reaction selectivity, and reduces the reaction temperature. The content of sucrose oleate monoesters is larger than 95%, the yield is larger than 90%, and the sucrose oleate monoester content and the yield are much higher than those reported by traditional methods and documents.

Description

technical field [0001] The invention belongs to the technical field of organic chemistry, and in particular relates to a method for preparing sucrose oleate with high monoester content. Background technique [0002] Sucrose Ester is a kind of biodegradable, green and safe non-ionic surfactant, which can be used as food emulsifier, anti-aging agent, wetting and dispersing agent, and is widely used in food, medicine, daily necessities, etc. It is also reported that some sucrose esters also have antibacterial, insecticidal, antitumor and other functions. The US FDA has approved that sucrose ester can partially replace fat and be used in the food industry. [0003] Sucrose oleate has good emulsifying, dispersing, moisturizing, decontamination, foaming, viscosity adjustment, anti-aging and anti-crystallization functions, and has been used in food emulsifiers, fruit preservatives, etc. There are many ways to synthesize sucrose esters, such as transesterification, microemulsion, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H13/06C07H1/00B01J31/22
CPCB01J31/181B01J2531/48C07H1/00C07H13/06
Inventor 张治国徐相雨钟旭辉周国朝
Owner 京山瑞生制药有限公司
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