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A kind of detection method of additive in midazolam medicine

A technology of midazolam and analysis method, which is applied in the field of detection and analysis, and can solve the problems that the detection of medicinal material DBP has not been reported.

Active Publication Date: 2021-12-14
上海微谱检测科技集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many detection methods and related researches on DBP in food packaging bags, but there is no report on the detection of DBP in medicinal materials, especially midazolam

Method used

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  • A kind of detection method of additive in midazolam medicine
  • A kind of detection method of additive in midazolam medicine
  • A kind of detection method of additive in midazolam medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Embodiment 1 provides the analytical method of the content of dibutyl phthalate in a kind of midazolam process liquid, comprises the steps:

[0070] S1: Preparation of sample mother liquor

[0071] Use 14mL of 1wt% dilute hydrochloric acid, add 1.000g of midazolam, stir until completely dissolved; use 800mL of water to dissolve 8.001g of sodium chloride to make a blank solution; add the midazolam solution to the blank solution, stir evenly, Adjust the pH to 3.204 with 0.02mol / L sodium hydroxide; add water to 1000mL.

[0072] S2: Preparation of sample solution

[0073] Take 25 mL of the sample mother liquor in an analysis bottle, add 5 mL of the mixed solution, shake well, and let stand; separate the organic phase, add anhydrous magnesium sulfate for dehydration, and take the supernatant for testing.

[0074] S3: Preparation of limit of quantitation (LOQ) solution

[0075] Take 25 mL of the sample mother solution in an analysis bottle, add 10 μL of the DBP reference s...

Embodiment 2

[0082] Embodiment 2 provides a kind of analytical method of the content of dibutyl phthalate in midazolam process liquid, comprises the steps:

[0083] S1: Preparation of sample mother liquor

[0084] Use 14mL of 1wt% dilute hydrochloric acid, add 1.000g of midazolam, stir until completely dissolved; use 800mL of water to dissolve 8.001g of sodium chloride to make a blank solution; add the midazolam solution to the blank solution, stir evenly, Adjust pH=3 with 0.02mol / L sodium hydroxide; add water to 1000mL.

[0085] S2: Preparation of sample solution

[0086] Take 25 mL of the sample mother liquor in an analysis bottle, add 5 mL of the mixed solution, shake well, and let stand; separate the organic phase, add anhydrous magnesium sulfate for dehydration, and take the supernatant for testing.

[0087] S3: Preparation of limit of quantitation (LOQ) solution

[0088] Take 25 mL of the sample mother solution in an analysis bottle, add 10 μL of the DBP reference substance mother...

Embodiment 3

[0095] Embodiment 3 provides the analytical method of the content of dibutyl phthalate in a kind of midazolam process liquid, comprises the steps:

[0096] S1: Preparation of sample mother liquor

[0097] Use 14mL of 1wt% dilute hydrochloric acid, add 1.000g of midazolam, stir until completely dissolved; use 800mL of water to dissolve 8.001g of sodium chloride to make a blank solution; add the midazolam solution to the blank solution, stir evenly, Adjust the pH to 3.5 with 0.02mol / L sodium hydroxide; add water to 1000mL.

[0098] S2: Preparation of sample solution

[0099] Take 25 mL of the sample mother liquor in an analysis bottle, add 5 mL of the mixed solution, shake well, and let stand; separate the organic phase, add anhydrous magnesium sulfate for dehydration, and take the supernatant for testing.

[0100] S3: Preparation of limit of quantitation (LOQ) solution

[0101] Take 25 mL of the sample mother solution in an analysis bottle, add 10 μL of the DBP reference sub...

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Abstract

The invention provides a method for analyzing the content of dibutyl phthalate in midazolam process liquid, which is characterized in that it comprises the following steps: S1: preparation of sample mother liquor; S2: preparation of sample solution; The obtained mother liquor of the sample was dissolved in the mixed solution, shaken evenly, left to stand, separated to obtain the organic phase, added anhydrous magnesium sulfate for dehydration, and the supernatant was taken for testing.

Description

technical field [0001] The invention relates to the field of detection and analysis, in particular to a detection method for additives in midazolam medicine. Background technique [0002] Phthalates are currently one of the most commonly used plasticizers. They are widely used in PVC container materials because they can significantly improve the processing performance and strength of PVC plastics. Since this kind of substance and PVC plastic mainly rely on the combination of intermolecular force, it is easy to release during use and cause pollution. Studies have shown that long-term exposure to phthalate plasticizers can cause endocrine disorders in organisms, reproductive lesions, tissue cancer and other serious consequences. Therefore, all countries have strict restrictions on the use of phthalate plasticizers, which limit the amount of such plasticizers. With the wide application of PVC materials, the pollution it brings cannot be ignored, but there is no report about i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 吴杰贾梦虹秦秋明杨潇军
Owner 上海微谱检测科技集团股份有限公司
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