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Composition used for preventing and treating alcoholic liver injury and having hangover alleviating effect

A technology of alcoholic liver injury and composition, applied in the field of traditional Chinese medicine, can solve the problems of unsatisfactory clinical effect and lack of particularly effective drugs, etc., to protect alcoholic liver injury, resist alcoholic liver injury, and reduce alcohol concentration Effect

Inactive Publication Date: 2019-04-16
西藏维桢医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiencies in the prior art, the present invention provides a composition for preventing and treating alcoholic liver injury and hangover effect, which solves the problem that the current prevention and treatment of alcoholic liver injury still lacks particularly effective drugs, and the main method adopted is In addition to alcohol abstinence, the main measures are supportive treatment, anti-hepatic steatosis and fibrosis treatment, etc., but the clinical effect is not satisfactory

Method used

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  • Composition used for preventing and treating alcoholic liver injury and having hangover alleviating effect
  • Composition used for preventing and treating alcoholic liver injury and having hangover alleviating effect
  • Composition used for preventing and treating alcoholic liver injury and having hangover alleviating effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: Chinese medicine capsule

[0020] Weigh 0.45kg of Embergia Radix, 0.22kg of Xiqingguo, 0.72kg of Xiebai, 0.55kg of Auricularia officinalis and 0.95kg of Prickly Pear Cactus, add 70% (v / v) ethanol for reflux extraction three times, and add an extraction solvent for the first time. 8 times the weight of the medicinal materials, reflux extraction for 2 hours, the second and third addition of the extraction solvent is 6 times the weight of the medicinal materials, 1 hour each time, the extracts are combined, and the extracts are concentrated under reduced pressure at 0.08 MPa and 70 °C to no Alcohol taste, add 0.5 times the weight of the total medicinal materials to suspend in water, add ethyl acetate for extraction twice, the first time adding ethyl acetate is 0.8 times the amount of water, the second time adding ethyl acetate is 0.6 times the amount of water, The ethyl acetate extracts were combined, and the extracts were concentrated under reduced pressure ...

Embodiment 2

[0021] Embodiment 2: the preparation of Chinese medicine granules

[0022] Weigh 0.40kg of Emblica officinalis, 0.20kg of Xiqingguo, 0.5kg of Xiebai, 0.50kg of Auricularia officinale, and 1.00kg of Prickly Pear Cactus, add 50% (v / v) ethanol for reflux extraction three times, and add the extraction solvent for the first time. 8 times the weight of the medicinal materials, reflux extraction for 2 hours, the second and third addition of the extraction solvent is 6 times the weight of the medicinal materials, 1 hour each time, the extracts are combined, and the extracts are concentrated under reduced pressure at 0.08 MPa and 70 °C to no Alcohol flavor, add 95% (v / v) ethanol to stir, let stand overnight, filter, and concentrate the filtrate under reduced pressure at 0.08MPa and 65°C into a thick paste, add 8 times the amount of sucrose powder, stir well, and make granules , package after drying.

Embodiment 3

[0023] Embodiment 3: Chinese medicine tablet

[0024] Weigh 0.5kg of Emblica Radix, 0.25kg of Xiqingguo, 0.62kg of Xiebai, 0.68kg of Auricularia nigra and 0.80kg of prickly pear cactus, add 50% (v / v) ethanol for reflux extraction three times, and add the extraction solvent for the first time as 8 times the weight of the medicinal materials, reflux extraction for 2 hours, the second and third addition of the extraction solvent is 6 times the weight of the medicinal materials, 1 hour each time, the extracts are combined, and the extracts are concentrated under reduced pressure at 0.08 MPa and 70 °C to no Alcohol taste, add 0.5 times the total weight of the medicinal materials to be suspended in water, add n-butanol for extraction twice, the first addition of n-butanol is 0.8 times the amount of water, the second addition of n-butanol is 0.6 times the amount of water, The n-butanol extracts were combined, the extracts were concentrated under reduced pressure at 0.08MPa and 82°C t...

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Abstract

The invention relates to a composition used for preventing and treating alcoholic liver injury and having a hangover alleviating effect, relating to the technical field of traditional Chinese medicine. The composition is composed of, by weight parts, 1-12 parts of emblic leaf flower fruit, 1-5 parts of fructus terminaliae immaturus, 2-15 parts of longstamen onion bulb, 5-19 parts of cynanchum auriculatum royle ex wight and 2-35 parts of pome cactus. The pharmaceutical composition is prepared into tablets, granules, powders, pills, tea bags, capsules, decoctions, oral liquids, dripping pills orsyrups. The composition used for preventing and treating alcoholic liver injury and having a hangover alleviating effect has good effects of protection against alcoholic liver damage and hangover alleviation by animal test, and the pharmaceutical composition can be used for preparing medicines or health care products used for preventing and treating alcoholic liver injury and having the hangoveralleviating effect.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a composition for preventing and treating alcohol-induced liver damage and anti-alcoholic effects. Background technique [0002] Alcoholic liver injury refers to the damage to the liver caused by an excessive intake of alcohol or long-term heavy drinking. If no intervention is taken, it will develop into alcoholic liver disease, which is clinically manifested as alcoholic fatty liver, alcoholic hepatitis, and alcoholic liver fibrosis. , alcoholic liver cirrhosis. Studies have shown that alcohol has become the second leading cause of liver damage after viral hepatitis, especially in a populous country with a profound tradition of alcohol culture such as my country, alcoholic liver injury has become an important social and medical problem in society. Injuries not only cause physical damage to drinkers, but also bring a series of social problems. At present, t...

Claims

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Application Information

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IPC IPC(8): A61K36/8962A61P1/16A61P39/02A23L33/105
CPCA23V2002/00A61K36/185A61K36/27A61K36/33A61K36/47A61K36/8962A61K2236/333A61K2236/51A23L33/105A61P1/16A61P39/02A61K2300/00A23V2250/21A23V2200/334
Inventor 杨俊松罗广建
Owner 西藏维桢医药科技有限公司
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