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Method for identifying human radiation response biomarkers based on various plant genomes

A plant genome and biomarker technology, applied in genomics, biostatistics, bioinformatics, etc., to promote interdisciplinary research and extensive reference

Active Publication Date: 2019-04-05
DALIAN MARITIME UNIVERSITY
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Problems solved by technology

Since the DDR pathway is highly conserved in the radiation response mechanisms of animals and plants, it provides great opportunities and challenges for breaking the barriers between animals and plants, promoting interdisciplinary research, and finding new radiation biomarkers.

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  • Method for identifying human radiation response biomarkers based on various plant genomes
  • Method for identifying human radiation response biomarkers based on various plant genomes
  • Method for identifying human radiation response biomarkers based on various plant genomes

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Embodiment Construction

[0033] The specific embodiments of the present invention will be further described in detail below mainly in conjunction with the accompanying drawings.

[0034] figure 1 It is a flowchart of a method for identifying human radiation response biomarkers based on multiple plant genomes in the present invention.

[0035] In this embodiment, as figure 1 As shown, the present invention relates to a method for identifying human radiation response biomarkers based on multiple plant genomes, including the following steps:

[0036] S1: In the Gene Ontology (GO) search tool QuickGO (https: / / www.ebi.ac.uk / QuickGO / ), search for the semantic relationship of response to radiation, and select 7 different The types of radiation response GO semantics are "response to ionizing radiation(GO:0010212)", "response to X-ray(GO:0010165)", "response to gamma radiation(GO:0010332)", "response to UV" (GO:0009411)", "response to UV-A(GO:0070141)", "response to UV-B(GO:0010224)", "response to UV-C(GO:0010225)...

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Abstract

The invention discloses a method for identifying human radiation response biomarkers based on various plant genomes. The method comprises the steps that a gene ontology (GO) semantic relationship of aradiation response is retrieved, and annotated genes in various plants and orthologous genes in arabidopsis are obtained; a union set of the orthologous genes in the arabidopsis and a radiation quality specific gene set for each GO semantics of various plants are calculated; by means of protein interaction network analysis, a gene set with protein connectivity greater than a set threshold value is obtained; the occurrence number of genes in the various plants is counted, and a gene set with the gene diversity greater than the set threshold value is obtained; finally, by means of gene homologyanalysis, the orthologous gene set of the genes in human is obtained, and the human radiation response biomarkers are guided. Accordingly, the problem that new human radiation response biomarkers need to be screened by means of plant genomes. The method has the application prospects in the aspects of radiation dose estimation, radiation damage diagnosis and radiation health risk early warning.

Description

Technical field [0001] The invention belongs to the field of biological information technology, and relates to a method for mining human radiation response biomarkers by using multiple plant genome data. Background technique [0002] With the increasingly widespread and in-depth application of nuclear energy, countries are paying more and more attention to radiation safety issues. Among them, the impact of radiation on human health has attracted more and more attention. Radiation exposure can cause damage to the organism's genetic material, such as DNA breaks and gene mutations, and cause chromosomal aberrations, cell inactivation, and genome instability. For humans, a certain dose of radiation exposure can damage the human bone marrow, skin, central nervous system, reproductive system and other tissues, organs or systems, causing cataracts and even cancer, leukemia and other diseases. Then, how to accurately estimate the radiation dose of the exposed person, diagnose radiation...

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Application Information

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IPC IPC(8): G16B20/00G16B50/10G16B40/00
Inventor 赵磊何欣叶陈鑫鹏姚婷婷宓东孙野青
Owner DALIAN MARITIME UNIVERSITY
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