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Gold nanorod and preparation method and application thereof

A technology of gold nanorods and gold seeds, which is applied in the field of nanorods, can solve the problems of affecting the detection of the analyte, difficult to clean, and the absorption peak of the substrate cannot be completely ignored, and achieves weak background signal intensity, high reproducibility, and absolute value small effect

Active Publication Date: 2019-04-05
安徽中科赛飞尔科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, when using gold nanorods as the SERS substrate, hexadecyltrimethylammonium bromide is mainly used as the coating agent, but hexadecyltrimethylammonium bromide is used as the coating agent to prepare gold nanorods as the SERS substrate. , cetyltrimethylammonium bromide is difficult to clean, and the absorption peak of the substrate itself cannot be completely ignored, which will affect the detection of the analyte. Therefore, it is necessary to prepare a substrate with less interference

Method used

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  • Gold nanorod and preparation method and application thereof
  • Gold nanorod and preparation method and application thereof
  • Gold nanorod and preparation method and application thereof

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Embodiment 1

[0040] A preparation method of gold nanorods, said method comprising the steps of:

[0041] S1. Preparation of gold seed solution: mix tetrachloroauric acid solution with cetyltrimethylammonium bromide solution, inject sodium borohydride solution, and mix well to obtain a seed solution;

[0042] S2. Prepare growth solution: mix tetrachloroauric acid solution with silver nitrate solution and coating agent, add hydrogen chloride solution and ascorbic acid, and mix evenly to obtain growth solution;

[0043] S3. Inject the gold seed solution into the growth solution, let it grow for more than 6 hours, and obtain gold nanorods with an aspect ratio of 2-4, and its UV-vis spectrum is as follows: figure 1 As shown in (A), the TEM image is as figure 1 As shown in (D), the Zeta potential is as figure 2 As shown; After the obtained gold nanorods were centrifuged and concentrated at 7500rpm for 10min, an appropriate amount was added dropwise on the cleaned silicon wafer; a Raman spectr...

Embodiment 2

[0059] A preparation method of gold nanorods, said method comprising the steps of:

[0060] S1. Preparation of gold seed solution: mix tetrachloroauric acid solution with cetyltrimethylammonium bromide solution, inject sodium borohydride solution, and mix well to obtain a seed solution;

[0061] S2. Prepare growth solution: mix tetrachloroauric acid solution with silver nitrate solution and coating agent, add hydrogen chloride solution and ascorbic acid, and mix evenly to obtain growth solution;

[0062] S3. Inject the gold seed solution into the growth solution, let it grow for more than 6 hours, and obtain gold nanorods with an aspect ratio of 2-4, and its UV-vis spectrum is as follows: figure 1 As shown in (B), the TEM image is as figure 1 As shown in (E), the Zeta potential is as figure 2 As shown; After the obtained gold nanorods were centrifuged and concentrated at 7500rpm for 10min, an appropriate amount was added dropwise on the cleaned silicon wafer; a Raman spectr...

Embodiment 3

[0078] A preparation method of gold nanorods, said method comprising the steps of:

[0079] S1. Preparation of gold seed solution: mix tetrachloroauric acid solution with cetyltrimethylammonium bromide solution, inject sodium borohydride solution, and mix well to obtain a seed solution;

[0080] S2. Prepare growth solution: mix tetrachloroauric acid solution with silver nitrate solution and coating agent, add hydrogen chloride solution and ascorbic acid, and mix evenly to obtain growth solution;

[0081] S3. Inject the gold seed solution into the growth solution, let it grow for more than 6h, and obtain gold nanorods with an aspect ratio of 2-4; its UV-vis spectrum is as follows: figure 1 As shown in (C), the TEM image is as figure 1 As shown in (F), the Zeta potential is as figure 2 As shown; After the obtained gold nanorods were centrifuged and concentrated at 7500rpm for 10min, an appropriate amount was added dropwise on the cleaned silicon wafer; a Raman spectrometer wa...

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Abstract

The invention relates to the technical field of nanorods, in particular to a gold nanorod. The gold nanorod is prepared from raw materials of a coating agent, and the coating agent is one of dodecyltrimethylammonium bromide, N-dodecyl-N-2-hydroxyethyl-N,N-dimethyl ammonium bromide, N-dodecyl-N,N-dihydroxyethyl-N-methyl ammonium bromide. The invention further discloses a preparation method and application of the nanorod. Three novel cationic surfactants are provided to serve as the coating agent to prepare the gold nanorod, the obtained gold nanorod with the positive charge and pigment molecules with the negative charge achieve an electrostatic adsorption effect, detection of pigment molecules is facilitated, and the nanorod serves as a surface-enhanced Raman spectrum substrate material tobe used for detection of the pigment molecules, and has the advantages of weak background signal intensity, high sensitivity, high reproducibility and the like.

Description

technical field [0001] The invention relates to the technical field of nanorods, in particular to a gold nanorod and its preparation method and application. Background technique [0002] Surface-enhanced Raman spectroscopy (SERS) has become a powerful and convenient analysis and detection tool due to its high sensitivity, simple operation, and short detection cycle. The SERS technology has no special requirements for the test sample, the sample amount is small, the sample preparation is simple and fast, and the application range is wide. The specificity of SERS spectrum is very good, and each molecule has its own special Raman spectrum, which has been widely used in food safety, environmental protection, interface science, nanoscience, chemical analysis and other fields. [0003] SERS active substrate is the premise of obtaining SERS signal and also the cornerstone of SERS technology. In order to realize the potential of SERS technology, the prepared SERS substrate should ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F1/00B22F9/24B82Y40/00G01N21/65
CPCG01N21/658B82Y40/00B22F9/24B22F1/054
Inventor 杨良保曹晨泰董荣录
Owner 安徽中科赛飞尔科技有限公司
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