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A kind of reduced graphene oxide antibacterial dressing and preparation method thereof

A graphene and antibacterial layer technology, applied in the field of reduced graphene oxide antibacterial dressings and its preparation, can solve the problems of low antibacterial activity, unfavorable wound healing, poor biocompatibility, etc., achieve good antibacterial effect, easy dressing change, The effect of promoting repair and growth

Active Publication Date: 2021-09-21
SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In view of the shortcomings of the prior art described above, the object of the present invention is to provide a reduced graphene oxide antibacterial dressing and a preparation method thereof, which overcomes the poor biocompatibility of antibacterial dressing materials in the prior art, low antibacterial activity, and unfavorable wound healing. And other issues

Method used

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  • A kind of reduced graphene oxide antibacterial dressing and preparation method thereof
  • A kind of reduced graphene oxide antibacterial dressing and preparation method thereof
  • A kind of reduced graphene oxide antibacterial dressing and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] Adding 1 part by mass of graphene oxide to deionized water to form a 1 g / L graphene oxide dispersion, adding 5 parts by mass of ascorbic acid, stirring and reacting for 12-24 hours, filtering and drying to obtain reduced graphene oxide;

[0046]Take 1 mass part of reduced graphene oxide and dissolve it in dimethylformamide, add 1 mass part of menthol, react with microwave power 400W for 2 hours, and obtain the reduced graphene oxide-menthol compound after separation and purification;

[0047] Reduced graphene oxide-menthol complex at 15g / m 2 Spray evenly on the gauze, UV 200J / m 2 It was activated by irradiation for 48 hours to obtain an antibacterial layer.

[0048] The base layer is combined with the antibacterial layer, and the reduced graphene oxide antibacterial dressing is obtained after cutting, shaping and disinfection.

Embodiment 2

[0050] 1 mass part of graphene oxide is added to deionized water to form a 6g / L graphene oxide dispersion, 10 mass parts of hydrazine hydrate is added, stirred and reacted for 12 hours, filtered and dried to obtain reduced graphene oxide;

[0051] Take 1 mass part of reduced graphene oxide and dissolve it in DMSO, add 10 mass parts of menthol, and react with a microwave power of 700W for 0.5 hours, and obtain the reduced graphene oxide-menthol complex after separation and purification;

[0052] Reduced graphene oxide-menthol complex at 10g / m 2 The amount of coating on the gauze, UV 500J / m 2 It was activated by irradiation for 30 hours to obtain an antibacterial layer.

[0053] The base layer is combined with the antibacterial layer, and the reduced graphene oxide antibacterial dressing is obtained after cutting, shaping and disinfection.

Embodiment 3

[0055] 1 mass part of graphene oxide is added to deionized water to form a 10g / L graphene oxide dispersion, 8 mass parts of ascorbic acid are added, stirred and reacted for 15 hours, filtered and dried to obtain reduced graphene oxide;

[0056] Take 1 mass part of reduced graphene oxide and dissolve it in dimethylformamide, add 8 mass parts of menthol, and react for 1 hour at a microwave power of 560W, and obtain a reduced graphene oxide-menthol compound after separation and purification;

[0057] Reduced graphene oxide-menthol complex at 12g / m 2 The amount of coating on the gauze, UV 800J / m 2 It was activated by irradiation for 36 hours to obtain an antibacterial layer.

[0058] The base layer is combined with the antibacterial layer, and the reduced graphene oxide antibacterial dressing is obtained after cutting, shaping and disinfection.

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Abstract

The invention discloses a reduced graphene oxide antibacterial dressing and a preparation method thereof, wherein the reduced graphene oxide antibacterial dressing comprises at least one base layer and one antibacterial layer. Wherein the antibacterial layer comprises a reduced graphene oxide-menthol complex and a carrier material. The reduced graphene oxide material acts as a good hydrogen bond acceptor, and the hydroxyl group in the menthol structure acts as a hydrogen bond donor, forming hydrogen bonding and molecular machine interactions with the reduced graphene oxide, and the resulting complex has a good antibacterial effect. Wound damaged tissue has high biocompatibility and can effectively promote the repair and growth of damaged tissue.

Description

technical field [0001] The invention relates to the technical field of medical dressings, in particular to a reduced graphene oxide antibacterial dressing and a preparation method thereof. Background technique [0002] Medical dressings are wound-wrapping supplies, medical materials used to cover sores, wounds or other damages. Medical dressings are suitable for the period of wound granulation, which can absorb excess wound exudate, block external foreign bodies and some bacteria, protect exposed nerve endings, and relieve pain. In order to avoid wound infection, certain antibacterial ingredients are usually added to medical dressings. Commonly used antibacterial ingredients include anions, chitosan and antibacterial drugs, etc. [0003] Graphene oxide is a nanomaterial formed by the oxidation of graphene. Its carbon atoms are arranged in a single layer, and the surface has a large number of oxygen-containing functional groups, which has good hydrophilicity and has better ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/18A61L15/20A61L15/42A61L15/44A61L15/46
CPCA61L15/18A61L15/20A61L15/42A61L15/44A61L15/46A61L2300/108A61L2300/216A61L2300/404
Inventor 刘克杨荣华汪海
Owner SHANDONG FIRST MEDICAL UNIV & SHANDONG ACADEMY OF MEDICAL SCI
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