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Nutritional compositions with 2fl and lnnt for use in preventing and/or treating non-rotavirus diarrhea by acting on the gut microbiota dysbiosis

A technology of nutritional composition and microbiome, which can be applied to medical preparations containing active ingredients, drug combinations, and resistance to vector-borne diseases, etc., and can solve problems such as not considering the function of intestinal microorganisms.

Pending Publication Date: 2019-04-02
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0028] However, there are currently no solutions to treat or prevent non-rotavirus diarrhea by bringing the overall gut microbiota (i.e. overall / whole / all / total microbiota) close to normal levels
[0029] Existing solutions also don't seem to take gut microbial function into account

Method used

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  • Nutritional compositions with 2fl and lnnt for use in preventing and/or treating non-rotavirus diarrhea by acting on the gut microbiota dysbiosis
  • Nutritional compositions with 2fl and lnnt for use in preventing and/or treating non-rotavirus diarrhea by acting on the gut microbiota dysbiosis
  • Nutritional compositions with 2fl and lnnt for use in preventing and/or treating non-rotavirus diarrhea by acting on the gut microbiota dysbiosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0262] Table 1 below gives an example of the composition of a nutritional composition (eg infant formula) according to the present invention. This composition is given by way of example only.

[0263]

[0264]

[0265] Table 1 : Examples of the composition of nutritional compositions (eg infant formulas) according to the invention

Embodiment 2

[0267] Clinical Study Description

[0268] One hundred and twenty hospitalized infants and young children with acute diarrhea participated in this prospective single-centre study. Male (for easier separation of feces from urine) infants and young children aged 6 to 24 months with a history of watery diarrhea of ​​less than 48 hours and who received written consent from their parents were included in the trial. Infants and young children with systemic infections, malnutrition (Z-score < -3), or major medical abnormalities were excluded. Infants and young children who had received or required antibiotics were also excluded from the trial. Infants and young children enrolled in the trial had to be negative for invasive diarrhea, negative for Vibrio cholerae on dark-field microscopy, and negative for rotavirus by ELISA in stool. Stool samples were investigated for the presence of ETEC, EPEC or EAEC according to standard procedures of icddr,b (Svenungsson B et al., Enteropathog...

Embodiment 3

[0283] Clinical Study Description

[0284] Carried out at the Maternal and Fetal Unit, Neonatology Unit and Neonatal Intensive Care Unit (Dipartimento Materno Infantile, Unità Operativa Complessa di Neonatologia e Terapia Intensiva Neonatale) of AOUP "Paolo Giaccone" in Palermo, Italy and the Pediatric Unit (Kinderartsenpraktijk) in Hasselt, Belgium safety test.

[0285] This study is a randomized, controlled, two-center interventional clinical trial of 2 parallel formula-fed groups. The study population in the formula-fed group consisted of healthy full-term male and female infants, aged 0 to 14 days, who were exclusively formula-fed at enrollment. Eligible infants were randomly assigned to one of two study formulas (control or test), using method of delivery (vsc or cesarean) and sex as stratification factors. For Phase 1, randomized infants receive exclusive feeding of test or control formula from enrollment to 4 months of age in amounts appropriate for their body weigh...

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Abstract

The present invention relates to a nutritional composition comprising at least one fucosylated oligosaccharide and at least one N-acetylated oligosaccharide for use in preventing and / or treating non-rotavirus diarrhea in infants or young childrenby acting on the dysbiosis of the microbiota preceding and / or following the non-rotavirus diarrhea. The composition can be an infant formula and is in particular intended for infants between 0 and 12 months of age fed predominantly with infant formula. It promotes a healthy intestinal flora and has beneficial short and long terms effects.

Description

technical field [0001] The present invention relates to nutritional compositions for infants or young children and their health effects. Such compositions comprise specific oligosaccharides and are effective in the prevention and / or treatment of non-rotavirus diarrhea in infants or young children. In particular, the present invention relates to infant formulas comprising human milk oligosaccharides (HMOs) that induce a more normalized overall gut microbiota. Background technique [0002] Breastfeeding is recommended for all infants. However, in some cases, breastfeeding is not sufficient or successful, or the mother does not choose to breastfeed, for some medical reason. Nutritional compositions, such as infant formulas, have been developed for these conditions. [0003] Nutritional compositions for infants and young children are usually sold as powders for reconstitution with water or in some cases as ready-to-drink or concentrated liquid compositions. These composition...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/702A23L33/00A61P1/14
CPCA23L33/40A23L33/10A61K31/702A61P1/14Y02A50/30A61K2300/00A23V2002/00A23V2200/32A23V2250/282
Inventor B·博格N·斯普伦格H·布吕索
Owner SOC DES PROD NESTLE SA
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