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Multi-dimensional liquid chromatography separation system based on two-position eight-way valve

A multi-dimensional liquid chromatography and separation system technology, applied in the direction of material separation, analysis materials, measurement devices, etc., can solve the problems that cannot fully meet the complex sample system's difficult repeated analysis, separation and preparation needs, and achieve a wide range of applications, The effect of improved chromatographic separation ability

Pending Publication Date: 2019-04-02
李宜珊
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  • Description
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Problems solved by technology

The system only has two-dimensional chromatographic separation capability, and cannot fully meet the difficult repeated analysis, separation and preparation needs of complex sample systems

Method used

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  • Multi-dimensional liquid chromatography separation system based on two-position eight-way valve
  • Multi-dimensional liquid chromatography separation system based on two-position eight-way valve
  • Multi-dimensional liquid chromatography separation system based on two-position eight-way valve

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Embodiment

[0036] Embodiment: A kind of structure of multidimensional liquid chromatography separation system

[0037] In this embodiment, the enrichment column array B has 9 enrichment columns, which are sequentially numbered as the first enrichment column of the enrichment column array B, the second enrichment column, etc., and the last number is the column of the enrichment column array B. The ninth enrichment column; the enrichment column array A is a two-stage enrichment column array, and each enrichment column array has 9 enrichment columns, that is, the enrichment column array A has 18 enrichment columns, and the numbers are enrichment The first enrichment column of column array A, the second enrichment column, etc., the last number is the 18th enrichment column of enrichment column array A; the liquid chromatography separation column array has 5 separation columns, which are numbered sequentially The first separation column, the second separation column, etc., the last one is the...

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Abstract

The invention provides a multi-dimensional liquid chromatography separation system. The system comprises a high-performance liquid chromatography gradient pump A, a high-efficiency liquid chromatography gradient pump B, a high-performance liquid chromatography diluting pump, a gradient mixer A, a gradient mixer B, a sample injection valve, an enrichment column array A, an enrichment column array B, a fraction collector, a liquid chromatography separation column array, a detector, a two-position eight-way valve and a connecting pipeline; and conversion between a previous one-dimensional separation state and a next one-dimensional separation state is realized through switching of the two-position eight-way valve, and chromatographic separation of three dimensions or above is realized. A chromatographic separation column of each dimension is selected through the liquid chromatography separation column array; and on the basis of the same gradient elution system and the same detector, fullonline monitoring and control of multi-dimensional chromatography separation are realized, and the cleaning degree of enrichment columns and separation columns is controllable. The separation of all dimensions is connected through the enrichment columns, and the diluting pump is used for assisting in enrichment or trapping of compounds. Different chromatography stationary phase and mobile phase combinations are selected, so that efficient separation of monomeric compounds in a complex system sample with high separation difficulty is realized.

Description

technical field [0001] The invention belongs to the technical field of high performance liquid chromatography separation, and relates to a multidimensional liquid chromatography separation system. Background technique [0002] With the development of separation technology, exploring and separating components in complex sample systems has become a hot research field. Multidimensional liquid chromatography technology can effectively improve the resolution of complex sample component separation by increasing peak capacity, and has become the development direction of fast chromatography separation technology. Multidimensional liquid chromatography technology is a liquid chromatography technology that sequentially injects the eluent of the first-dimensional chromatographic column of the sample into the subsequent dimensional chromatographic column for further separation. This separation technology can utilize two or more chromatographic columns with different separation mechanis...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/08G01N30/60
CPCG01N30/06G01N30/08G01N30/6043
Inventor 李宜珊
Owner 李宜珊
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