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Core-shell structure cellulose-based probiotic microcapsule and preparation method thereof

A technology of core-shell structure and cellulose, which is applied in the field of core-shell structure cellulose-based probiotic microcapsules and its preparation, can solve problems such as limited application, cellulose insoluble surface groups, and instability of sodium alginate, and achieve good results. Effects of sustained release performance, avoidance of loss of activity, good loading effect

Inactive Publication Date: 2019-03-29
INST OF OIL CROPS RES CHINESE ACAD OF AGRI SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, cellulose is insoluble in common solvents and has a single surface group, which limits its application as a pH-responsive probiotic embedding material.
At present, sodium alginate, starch, protein, etc. are common probiotic embedding materials, but these wall materials have certain deficiencies in probiotic embedding, for example, the instability of sodium alginate greatly limits its application

Method used

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  • Core-shell structure cellulose-based probiotic microcapsule and preparation method thereof
  • Core-shell structure cellulose-based probiotic microcapsule and preparation method thereof
  • Core-shell structure cellulose-based probiotic microcapsule and preparation method thereof

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Embodiment

[0033] Cellulose nanofiber / chitosan / sodium alginate probiotic microcapsule, which is a blend solution of cellulose nanofiber and probiotic, in Ca 2+ Under the action of cross-linking agent, cellulose nanofiber probiotic microcapsules were prepared by ion cross-linking method, and then coated with water-soluble chitosan and sodium alginate with a deacetylation degree greater than 85%, and self-assembled layer by layer Technology prepared core-shell structure cellulose nanofiber / chitosan / sodium alginate probiotic microcapsules, with an average particle size of 5mm, showing an obvious core-shell structure. Control the load of probiotics to ~1.0×10 7 cfu, the effective delivery volume is 1.2×10 6 cfu / mL.

[0034] The preparation method of above-mentioned cellulose nanofiber / chitosan / sodium alginate probiotic microcapsule, concrete steps are as follows:

[0035] 1) Lactobacillus plantarum liquid (1mL, 1×10 7 cfu / mL) Lactobacillus plantarum sludge obtained by centrifugation (400...

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Abstract

The invention discloses a core-shell structure cellulose-based probiotic microcapsule which is prepared by preparing a core from a mixture of a cellulose nanofiber and probiotics under the crosslinking action of Ca<2+>, preparing a coating from water-soluble chitosan and sodium alginate and by implementing a layer-by-layer self-assembling technique. The microcapsule disclosed by the invention hasan average particle size of 2-5mm, and is of a remarkable core-shell structure, probiotics are mainly distributed in the core of the microcapsule, amount controllable loading of the probiotics is achieved, good pH response properties and probiotic slow-release properties can be achieved, and effective protection on the probiotic and target release in intestinal tracts are achieved.

Description

technical field [0001] The invention relates to the field of polymer materials, and relates to a core-shell structure cellulose-based probiotic microcapsule and a preparation method thereof. Background technique [0002] Probiotics can effectively regulate intestinal microbial flora and have significant curative effects on various human diseases such as inflammatory bowel disease, obesity, diabetes, etc., and their application as health improvers is gradually increasing. The surrounding environment, such as processing, storage, and human digestive tract, seriously affects the activity of probiotics, resulting in a significant reduction in the number of viable bacteria that reach the intestinal tract. The protection of probiotics by microcapsule technology is a hot research topic at home and abroad, and it is considered to be one of the most efficient and economical methods to protect the activity of probiotics. It can reduce the damage to probiotic cells caused by the extern...

Claims

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Application Information

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IPC IPC(8): A61K9/62A61K47/38A61K47/36A61K35/741A61K35/747A61K35/744A61P1/00A61P3/04A61P3/10
CPCA61K9/5036A61K35/741A61K35/744A61K35/747A61K47/38A61P1/00A61P3/04A61P3/10
Inventor 黄凤洪汤虎栾倩张浩鲍雨萍
Owner INST OF OIL CROPS RES CHINESE ACAD OF AGRI SCI
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