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Cooling gel sheet and preparation method thereof

A technology of antipyretic patch and gel matrix, which is applied in the field of medicine, can solve the problems of reduced applicability for children, reduced or even zero cooling effect, and achieves the effect of prolonging the antipyretic time, not being easily affected by temperature, and maintaining stability

Pending Publication Date: 2019-03-26
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Patent document CN201410534070.5 discloses a polymer hydrogel antipyretic patch for children and a preparation method thereof. The antipyretic patch and the hydrogel layer contain 10% to 20% of a polymer substance and 5% to 15% of a moisturizing factor , 0.08% to 1% menthol, 0.01% to 0.5% borneol, 73% to 90% distilled water, 0.2% to 2.0% ethanol. heat, so as to achieve the effect of cooling and antipyretic. It has the dual effects of physical cooling and natural cooling agent cooling. However, when the antipyretic patch is used, the rapid volatilization of menthol and borneol makes the subsequent cooling effect drop significantly or even zero. Many times Use can achieve long-term cooling effect, and repeated pasting will reduce the applicability of children

Method used

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  • Cooling gel sheet and preparation method thereof
  • Cooling gel sheet and preparation method thereof
  • Cooling gel sheet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1, a kind of antipyretic patch

[0028] The antipyretic patch is composed of a backing material non-woven fabric, a gel matrix layer and a cover lining material polycarboxyethylene film, and the gel matrix layer is composed of the following components and their mass percentages:

[0029] Menthol 0.5%, Tartaric Acid 0.2%, Silanediol Salicylate 0.5%, NP 700 Sodium Polyacrylate 4%, Glycerin 20%, Aluminum Glycol 0.15%, EDTA Disodium 0.2%, Preservative GC -040.2% and water 74.25%.

[0030] The preparation method is as follows:

[0031] S1. Add sodium polyacrylate, glycerin, aluminum glycolate and disodium edetate into water, mix well, and let stand for 8-12 hours to obtain mixed solution A;

[0032] S2. Add menthol, tartaric acid, silanediol salicylate and preservatives to water, mix well to obtain mixed solution B, add mixed solution B to the mixed solution A prepared in step S1, and stir for 10-15min , cooled to room temperature to obtain a mixed gel matrix; ...

Embodiment 2

[0034] Embodiment 2, a kind of antipyretic patch

[0035] The antipyretic patch is composed of a backing material non-woven fabric, a gel matrix layer and a cover lining material polycarboxyethylene film, and the gel matrix layer is composed of the following components and their mass percentages:

[0036] Menthol 1%, Tartaric Acid 0.4%, Silanediol Salicylate 1%, NP 700 Sodium Polyacrylate 7%, Glycerin 24%, Aluminum Glycol 0.3%, Disodium EDTA 0.26%, Preservative GC -040.35% and water 65.89%.

[0037] The preparation method is similar to Example 1.

Embodiment 3

[0038] Embodiment 3, a kind of antipyretic patch

[0039] The antipyretic patch is composed of a backing material non-woven fabric, a gel matrix layer and a cover lining material polycarboxyethylene film, and the gel matrix layer is composed of the following components and their mass percentages:

[0040] Menthol 0.75%, Tartaric Acid 0.36%, Silanediol Salicylate 1.5%, Sodium Polyacrylate 6%, Glycerin 24%, Aluminum Glycol 0.27%, Disodium EDTA 0.25%, Preservative GC-040.3 % and water 66.57%.

[0041] The preparation method is similar to Example 1.

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Abstract

The invention relates to the technical field of medicines, in particular to a cooling gel sheet and a preparation method thereof. The cooling gel sheet comprises a back lining material, a gel matrix layer and a cover lining material, wherein the gel matrix layer is prepared from menthol, tartaric acid, silanediol salicylate, sodium polyacrylate, glycerin, aluminum glycinate, disodium ethylenediamine tetraacetic acid, a preservative and water. The cooling gel sheet has the advantages that when the cooling gel sheet is stuck, the quick cooling effect is realized by the volatilizing of menthol and gasifying of water; because the silanediol salicylate absorbs a certain amount of menthol, part of menthol slowly volatilizes, the cooling time can be prolonged, and the defects of short action timeand poor suitability in the existing cooling gel sheet are overcome; the preservative contains glycerol octanoate, octyl hydroxamic acid and p-hydroxyacetophenone, so that the moisturizing effect ofglycerol is increased, the function of maintaining the stability of the hydrogel matrix in the gel sheet is realized, the easiness in solidification of the gel matrix due to influence by temperature and overquick evaporation of water is avoided, the stability of the hydrogel matrix in the gel sheet is maintained, and the cooling time is prolonged.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an antipyretic patch and a preparation method thereof. Background technique [0002] Fever is one of the most common clinical symptoms, usually caused by viral, bacterial infection or other diseases. Fever is a protective reaction of the human body. Fever can stimulate the phagocytic function of the reticuloendothelial system, form antibodies, increase the vitality of white blood cells, and detoxify the liver. However, fever can cause loss of appetite and fatigue, and affect the function of various organs and tissues in the body Function. In order to quickly cool down, people generally take antipyretic and analgesic drugs, as well as antibacterial and anti-inflammatory antibiotics, and taking drugs will bring adverse reactions to the human body, especially pregnant women, infants and other special groups should not take antibiotics. [0003] Antipyretic patches are also called...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/045A61K47/08A61K47/12A61K47/14A61K47/18A61K47/24A61P29/00A61F7/02
CPCA61K47/08A61K47/12A61K47/14A61K47/183A61K47/24A61P29/00A61F7/02A61K9/7023A61K31/045A61F2007/0219A61F2007/0261
Inventor 车七石刘少辉李新霞
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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