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Micro-nano imaging detection experiment device based on photoacoustic beam shaping

A technology of imaging detection and experimental equipment, applied in measuring equipment, material analysis through optical means, instruments, etc., can solve problems such as insufficient understanding and research, and achieve the effect of improving light absorption contrast and optimizing photoacoustic efficiency

Active Publication Date: 2019-03-22
UNIV OF SCI & TECH OF CHINA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the understanding and research on these scientific issues are far from enough
Regardless of whether theoretical analysis, traditional field simulation methods, or experimental methods are used to carry out research, it is quite difficult

Method used

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  • Micro-nano imaging detection experiment device based on photoacoustic beam shaping

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specific Embodiment

[0029] The specific embodiment of the present invention is the preferred embodiment of basic embodiment, specifically as follows:

[0030] In this embodiment, the multimode cylindrical dispersion fiber in the forward scanning probe 02 based on nonlinear photonic crystal beam shaping has a transmission laser wavelength band of 490-800nm, a total length of 3.6m, and a core diameter of 0.56mm; layer, the total diameter is about 1.6mm; the tail has a diffuse segment, the length is 2.2cm. The forward-scanning probe 02 based on nonlinear photonic crystal beam shaping is independently creatively produced. The system uses nonlinear photonic crystal micro-lenses to achieve focused light irradiation on imaging tissues. The transducer 10 realizes transmission on both sides of the sample pool 09 Sensing, embedded wavefront controlled backward tracking probe 11 adaptive scanning tracking acquisition. Based on this system, 28 illumination scans and 28 compressed sensing acquisitions are re...

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Abstract

The invention discloses a micro-nano imaging detection experiment device based on photoacoustic beam shaping. The micro-nano imaging detection experiment device comprises a dye laser light source, a light beam shaping forward scanning probe based on nonlinear photonic crystals, a first reflecting mirror, a three-dimensional electric platform, a beam expanding mirror, frosted glass, coupling liquid, an ascending and descending table, a sample pool, an energy converter, an embedded wavefront control backward tracking probe, a lock phase amplifier, a data collector and a computer. The experimentdevice can effectively work in a complicated photoacoustic field regulation control and self-adaption wavefront control marking-free detection mode; the computer is respectively connected with the dyelaser light source, the light beam shaping forward scanning probe, the three-dimensional electric platform, the energy converter, the light beam shaping forward scanning probe and the lock phase amplifier through signal wires. The multi-signal extension compensation correction, fast shearing, precise registering and the like are realized; The qualitative, positioning and quantitative EA (extension analysis) on multi-mode relevant target points of occurrence, development, transfer and induction apoptosis can also be realized.

Description

technical field [0001] The invention belongs to the technical field of multimodal micro-nano imaging and photoacoustic label-free detection, and particularly relates to a new experimental device for photoacoustic shaping based on nonlinear photonic crystals and real-time multimodal imaging detection of microfluids such as dendrobium phenol samples. Background technique [0002] Photoacoustic imaging detection has played an important role in analytical chemistry, systems biology, biophysics, clinical medicine, biopharmaceuticals and other fields since the appearance of photoacoustic effect. Photoacoustic imaging detection technology itself is constantly developing and improving in these applications. Reshaping the columnar diffuse light source into a tube beam has the advantages of irradiation depth and wide range, which reflects a new way of exciting resonance signals by means of modulated columnar beams in the infection channel and the telephoto tracking probe located at th...

Claims

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Application Information

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IPC IPC(8): G01N21/17
CPCG01N21/1702G01N2021/1706
Inventor 卢荣德方兆翔
Owner UNIV OF SCI & TECH OF CHINA
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