Nanogold-rod-containing hardener for treating vascular malformation, and preparation method

Abstract

The invention belongs to the technical field of vascular malformation drugs, and discloses a nanogold-rod-containing hardener for treating vascular malformation, and a preparation method. The nanogold-rod-containing hardener is prepared from lauromacrogol 400 injections and nanogold rods; the lauromacrogol 400 injections and the nanogold rods are sterilized; the lauromacrogol 400 injections with different concentrations are evenly mixed with the nanogold rods in different masses to prepare harder injections having different concentrations of the nanogold rods. The nanogold-rod-containing hardener has the advantages that the nano materials, namely nanogold rods have the photothermal conversion effect, light energy received by the nanogold rods can be converted into heat energy by irradiation of external laser of a certain wavelength, and the temperature is controllable; the nanogold rods and the liquid hardeners are uniformly mixed, the injections can be directly injected into vascularmalformation nidi by syringes, and the distribution of the nanogold rods can be kept consistent with that of the hardeners in blood vessels.

Description

technical field [0001] The invention belongs to the technical field of vascular malformation drugs and the field of minimally invasive surgical treatment of vascular malformations, and in particular relates to a nano-gold rod-containing sclerosing agent for the treatment of vascular malformations and a preparation method thereof. Background technique [0002] At present, the existing technologies commonly used in the industry are as follows: Vascular malformation is a benign vascular lesion with a certain degree of aggressiveness. For limited vascular malformation lesions with clear boundaries, surgical resection can be performed completely, while for diffuse or recurrent lesions with unclear boundaries, endocavitary laser combined with sclerotherapy can be used. It is currently the most commonly used surgical treatment option. The Chinese name of the hardener used in this scheme is α-isotridecyl-ω-hydroxyl-poly(oxygen-1,2-ethylene), and the molecular formula is HO(CH2CH2O)...

AI Technical Summary

Problems solved by technology

However, the existing intracavity laser combined with sclerosing agent therapy has the following defects: ①The existing main treatment plan is to use a fiber laser, the laser is transmitted to the head of the fiber through an optical fiber, only the head of the fiber can generate heat, and the heating range is limited

②When using existing methods for treatment, since only the head of the laser fiber generates heat, the fiber must be guided into the cavity of the vascular malformation lesion to play a therapeutic role

④It is precisely because of the above reasons that multiple punctures can cause secondary damage to the lesion and slow down the healing time of the lesion, and the damage factor is also one of the important factors that stimulate the spread or recurrence of vascular malformation; , but the laser fiber cannot completely ablate the blood vessel, which may cause damage to the surrounding normal tissue; ③The structure of the vascular malformation lesion is disordered and widely distributed, and it is difficult for artificial puncture to penetrate all parts of the vascular malformation lesion, so the laser fiber cannot achieve Evenly burn all parts of the lesion

[0006] (2) Although the sclerosing agent can be directly injected into the malformed blood vessels of the lesion, the laser fiber cannot completely ablate the blood vessels, which may cause damage to the surrounding normal tissues

[0007] (3) Due to the disordered structure and wide distribution of vascular malformation lesions, and the difficulty of artificial puncture throughout all parts of vascular malformation lesions, the laser fiber cannot evenly ablate all parts of vascular malformation lesions

[0009] Limitations of existing minimally invasive treatment options cannot be addressed if existing intracavity lasers continue to be utilized

Images