Liquid chromatography high pressure gradient valve and liquid chromatography inlet system

Abstract

The invention discloses a liquid chromatography high pressure resistant gradient valve and a liquid chromatography liquid inlet system, wherein the liquid chromatography high pressure resistant gradient valve comprises: a valve body and at least two high pressure valves; the valve body is provided with a mixing outlet and at least two Each interface is connected to the mixing outlet; each interface is connected to a high-pressure valve, and the high-pressure valve includes: a shell, a valve core, an elastic retainer, and an electric control drive. The liquid inlet chamber has a liquid inlet, the liquid outlet chamber has a liquid outlet, and the liquid outlet is connected to the interface; the valve core is movably arranged in the liquid outlet chamber; the elastic holder is arranged in the liquid outlet chamber, The elastic retainer stops against the spool so that the spool is blocked in the communication cavity; the electric control drive is arranged on the casing and cooperates with the spool to drive the spool to move, and the electric control drive drives the spool when receiving the liquid inlet information. The spool opens the communication cavity. The liquid chromatography high pressure resistant gradient valve of the invention has the characteristics of high pressure resistance and gradient accuracy.

Description

technical field [0001] The invention belongs to the field of liquid chromatography technical equipment, in particular to a liquid chromatography high-pressure resistant gradient valve and a liquid chromatography liquid inlet system. Background technique [0002] High performance liquid chromatography (HPLC) is often used in sample detection and analysis, as well as in the process of sample separation and purification. Usually, the HPLC system can withstand at least 42MPa pressure. High performance liquid chromatography conducts qualitative analysis based on the difference in the retention behavior of the tested sample on the chromatographic column and the time of elution by the solvent. Therefore, two or more solutions are often used as eluents, and linear gradients or linear gradients are realized by forming different elution ratios of each eluent over time, as well as a combination of linear gradients and linear gradients to form different gradients. The elution strength...

AI Technical Summary

Problems solved by technology

However, in this process, the four-way solenoid valve is prone to shock effects when it is working, resulting in inaccurate solution concentration gradients.

And the front end of the four-way solenoid valve is directly connected to the liquid storage bottle, and works under atmospheric pressure, the four-way solenoid valve cannot withstand high pressure, and the pressure difference with the high-pressure infusion pump is relatively large

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