Regimen adherence measure for insulin treatment based on glucose measurements and insulin pen data

Abstract

Systems and methods are provided for adjusting a standing insulin medicament dosage regimen for a subject. Fasting events are identified using autonomous timestamped glucose measurements of the subject in a first data set. A second data set, from one or more insulin pens used to apply the standing regimen, comprises records, each record comprising a timestamped event specifying an amount of injected insulin medicament. Each fasting event is characterized as adherent or nonadherent. A fasting event is adherent when the second data set includes one or more records that temporally and quantitatively establish adherence with the standing regimen during the fasting event. Conversely, a fasting event is nonadherent when the second data set fails to temporally and quantitatively establish adherence with the standing regimen. Dosages in the standing regimen are adjusted using glucose measurements contemporaneous with adherent fasting events and by excluding glucose measurements contemporaneouswith nonadherent fasting events.

Description

technical field [0001] The present disclosure generally relates to systems and methods for assisting patients and healthcare practitioners in managing insulin delivery to diabetic patients. Background technique [0002] Type 2 diabetes is characterized by a progressive disturbance of normal physiological insulin secretion. In healthy individuals, basal insulin secretion by pancreatic beta cells occurs continuously to maintain steady glucose levels over extended periods between meals. There is also prandial secretion in healthy individuals, where insulin is released rapidly in an initial first phase spike in response to a meal, followed by a sustained insulin secretion that returns to basal levels after 2-3 hours. [0003] Insulin is a hormone that binds to the insulin receptor to lower blood sugar by promoting the cellular uptake of glucose, amino acids and fatty acids into skeletal muscle and fat, and inhibiting the export of glucose from the liver. In normal healthy indi...

AI Technical Summary

Problems solved by technology

However, when this blood glucose measurement is in fact due to a forgotten basal or prandial insulin dose injection (as opposed to an insulin regimen that does not call for sufficient insulin dose), this can lead to insulin dose overdose and hypoglycemia. Adverse event

Also, the patient may log untaken insulin doses as taken

When this is not reflected in the glucose levels measured in the clinic (and / or HbA1c levels measured from such glucose levels), the healthcare practitioner may increase the dose of insulin medicament in the long-term insulin regimen on this basis, and therefore, The patient's dosing regimen may thus indicate dangerously high insulin doses which, if injected, would lead to overdose of the insulin medicament and hypoglycemia

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