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Tissue substitute materials and methods for tissue repair

A technology of grafting material and non-woven fabric is applied in repairing nerve tissue such as dura mater. Using the non-woven grafting material to repair tissue field can solve the problem of poor handling, complicated clinical application, and unattainable mechanical properties of synthetic grafts. requirements, etc.

Inactive Publication Date: 2019-03-01
ACERA SURGICAL INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Synthetic grafts also fall short in terms of mechanical properties approaching that of the dura mater, making these materials often poorly handled, which complicates their clinical application

Method used

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  • Tissue substitute materials and methods for tissue repair
  • Tissue substitute materials and methods for tissue repair
  • Tissue substitute materials and methods for tissue repair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] In this example, the performance of a gold standard xenogeneic collagen graft material is compared to an exemplary embodiment of a nonwoven graft material of the present invention.

[0065] Materials and methods

[0066] Research design

[0067] Ten female New Zealand white rabbits (5.0-5.5 months, Western Oregon Rabbit Company (Western Oregon Rabbit Company), Oregon Philomath (Philomath, OR)) were randomly divided into two groups (I, II), 5 in each group ( n=5). Group I served as a positive control, and all animals underwent bilateral craniotomy and dura resection, followed by bilateral surgical repair of induced dural defects using collagen graft material (Stryker, Inc. Kalamazoo, MI). Group II served as the experimental group, and all animals underwent bilateral craniotomy and dural resection, followed by bilateral surgical repair of the induced dural defect using a fully resorbable non-biological non-woven graft material. All animals underwent daily / weekly behavi...

Embodiment 2

[0097] In this example, the physical properties of the nonwoven web were determined by direct measurement of web fibers, pore size, mass, and dimensions.

[0098] Cut the test article into four parts, about 1 cm each 2 . Attach the cut section to a standard 12mm SEM stub using double-sided carbon tape. Two sections are positioned in a "concave side up" orientation and two sections are positioned in a "concave side down" orientation. Using a Denton Desk V sputter coater the samples were coated with approx. of gold coating. The physical properties analyzed were mean pore size, mean fiber diameter, mean thickness, side dimensions, mass and "areal density" (g / m 2 ). Dimensional data were collected by recording a series of secondary electron micrographs from each sample using a TESCANVega 3 scanning electron microscope. Specify a magnification level of 2kx to collect data. Images were also collected at 500X magnification. Physical properties were measured directly on the p...

Embodiment 3

[0100] In this example, non-destructive testing was performed on the nonwoven material of the present invention.

[0101] The mass is determined by weighing the sample on a balance. Use calibrated calipers to measure dimensions to cover the length and width of the material. Area (cm 2 ) is obtained by calculation. Calculate the "areal density" (g / m 2 ).

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PUM

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Abstract

Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.

Description

Background technique [0001] The present invention relates generally to nonwoven graft materials for specialized surgical procedures, such as neurosurgery, wound repair, oral surgery, skin repair and regeneration, head and neck surgery, endonasal surgery, and bone repair, the preparation of which nonwoven grafts The method of material, and the method for repairing tissue (such as neural tissue) using this non-woven graft material. More particularly, the present invention relates to a nonwoven graft material comprising at least two different fiber components consisting of different polymeric materials, a method of making the nonwoven graft material and using the same A method of repairing tissue in an individual in need thereof with a nonwoven graft material. [0002] Neurosurgery often results in the perforation or removal of the water-tight fibrous membrane around the brain called the dura mater. In all of these cases, the tissue barrier around the brain must be repaired in ...

Claims

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Application Information

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IPC IPC(8): A61L17/12D04H1/435D04H3/011C08L67/04A61K9/70A61F2/02
CPCA61K9/70D04H1/435D04H3/011C08L67/04A61L27/18A61L27/56A61L27/58D04H1/728D04H3/009D04H3/16
Inventor M·麦克尤恩
Owner ACERA SURGICAL INC
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