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A kind of structurally stable nano-bismuth sphere cluster and its preparation method and application

A stable structure and nano-bismuth technology, which is applied in the field of biological and medical nanomaterials, can solve the problems that the drug-loaded carrier cannot be released in a controlled manner, and the contrast agent cannot be used at the same time.

Active Publication Date: 2021-04-20
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention solves the technical problems that the contrast agent in the prior art cannot be used simultaneously under various imaging conditions, the drug-loaded carrier cannot be released in a controlled manner, and the contrast agent in the prior art is toxic and has potential safety hazards

Method used

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  • A kind of structurally stable nano-bismuth sphere cluster and its preparation method and application
  • A kind of structurally stable nano-bismuth sphere cluster and its preparation method and application
  • A kind of structurally stable nano-bismuth sphere cluster and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0036] Embodiment 1: Preparation of nano-bismuth spherical clusters

[0037] Dissolve 1g of Livzon Dele (containing bismuth potassium citrate BPC and sodium carboxymethylcellulose) in ultrapure water, dilute to 5mL, absorb 2mL and re-dilute to 25mL ultrapure water, and irradiate with ultraviolet light for 3min Finally, centrifuge at 5000rad / min for 15min to take the supernatant to obtain nanobismuth sphere clusters.

Embodiment 2

[0038] Example 2: Preparation of drug-loaded nanobismuth spherical clusters

[0039] The process of preparing drug-loaded nanobismuth spherical clusters is as follows: figure 1 shown. Add nano-bismuth spherical clusters synthesized in Example 1 (the mass of bismuth atoms is 1 g) and 40 μg DOX (doxorubicin hydrochloride) to 5 mL PBS and stir in the dark for 12 h, centrifuge at 8000 rad / min for 10 min, discard the supernatant, and resuspend the precipitate , repeated three times to obtain drug-loaded nano-bismuth sphere clusters, which were stored in the dark. Schematic diagram of the structure of the drug-loaded nanobismuth sphere clusters. figure 2 shown.

Embodiment 3

[0040] Embodiment 3: Observation by transmission electron microscope on the nano-bismuth spherical clusters of the present invention

[0041] The nano-bismuth spherical clusters of the present invention prepared in Example 1 are observed under a transmission electron microscope, and the transmission electron microscope diagram is shown in image 3 . The picture shows nano-bismuth sphere clusters, and the illustration in the upper left corner shows elemental bismuth spheres under a high-resolution transmission electron microscope, and the crystal lattice is clearly visible.

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Abstract

The invention discloses a nano-bismuth spherical cluster, a drug-loaded nano-bismuth spherical cluster, a preparation method and an application, and belongs to the field of biological and medical nano-materials. The invention discloses a high-safety multifunctional nano-probe synthesized simply and quickly by one-step method derived from oral gastric medicine. Nanobismuth spherical clusters with CT / photoacoustic dual-modal imaging function were synthesized by one-step method after ultraviolet light irradiation. The nanobismuth spherical cluster has the advantages of uniform size, good stability, high photothermal conversion efficiency, low toxicity, good biocompatibility and the like. After the probe is adsorbed with antitumor drugs, it can be directly used in animal experiments. The probe can be phagocytized by tumor cells through the EPR effect. At the same time, the near-infrared light and the acidic environment of the tumor can be used to realize the controlled release of the loaded anti-tumor drug, achieving the purpose of combined drug and photothermal therapy, and the therapeutic effect is significantly better than single mode therapy. .

Description

technical field [0001] The invention belongs to the field of biological and medical nanomaterials, and in particular relates to a structure-stable nano-bismuth ball cluster, a preparation method and an application thereof. Background technique [0002] Cancer seriously threatens human health and life. Especially in developing countries, due to factors such as few effective screening techniques and low levels of early diagnosis techniques, cancers are generally discovered late, coupled with poor tumor treatment effects, large side effects, high recurrence and metastasis rates, and poor accuracy. Cancer treatment is more difficult. Therefore, it is of great significance to explore safe and simple diagnosis and treatment techniques to improve the survival rate of cancer patients. [0003] Imaging methods such as CT, MRI, PET, and ultrasound play an important role in the diagnosis of tumors. However, due to the different principles of different imaging methods, each imaging m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22A61K49/04A61K47/61A61K41/00A61K31/704A61P35/00
CPCA61K31/704A61K41/0052A61K49/0002A61K49/04A61K49/225A61K47/61A61P35/00A61K2300/00
Inventor 赵元弟宣扬陈威杨孝全张若筠
Owner HUAZHONG UNIV OF SCI & TECH
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