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Composition for preventing and treating osteoporosis as well as preparation method and application of the composition

A technology for osteoporosis and a composition is applied in the field of a composition for preventing and treating osteoporosis and its preparation field, and achieves the effects of easily obtaining raw materials, inhibiting differentiation and reducing the incidence of osteoporosis

Active Publication Date: 2019-02-26
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the use of propolis alcohol extract, bee pollen water extract, modified pectin powder and donkey-hide gelatin powder for the prevention and treatment of osteoporosis

Method used

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  • Composition for preventing and treating osteoporosis as well as preparation method and application of the composition
  • Composition for preventing and treating osteoporosis as well as preparation method and application of the composition
  • Composition for preventing and treating osteoporosis as well as preparation method and application of the composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation of embodiment 1 composition powder of the present invention (one)

[0037] The weight ratio of each natural product is: 10g of propolis alcohol extract, 10g of bee pollen water extract, 70g of modified pectin powder, and 10g of donkey-hide gelatin powder.

[0038] (1) Preparation of propolis ethanol extract: Chinese poplar propolis or Brazilian propolis raw materials were frozen and pulverized, refluxed and extracted with 70% ethanol solution at 75°C for 2 hours, and the extract was freeze-dried and pulverized through a 60-mesh sieve.

[0039] (2) Preparation of water extract of bee pollen: ultrafine pulverization of camellia pollen, lotus pollen or rape pollen, hot soaking in distilled water at 90°C for 3 hours, freeze-dried extract, and pulverizing through a 60-mesh sieve.

[0040] (3) Preparation of modified pectin: Pectin from citrus, carrot, silkworm excrement, sunflower dish and other sources is through alkaline hydrolysis (1% NaOH aqueous solution i...

Embodiment 2

[0043] The preparation of embodiment 2 composition powder of the present invention (two)

[0044] The weight ratio of each natural product is: 5g of propolis alcohol extract, 15g of bee pollen water extract, 65g of modified pectin powder, and 15g of donkey-hide gelatin powder.

[0045] (1) Preparation of propolis ethanol extract: Chinese poplar propolis or Brazilian propolis raw materials were frozen and pulverized, refluxed and extracted with 75% ethanol solution at 70°C for 3 hours, and the extract was freeze-dried and pulverized through a 60-mesh sieve.

[0046] (2) Preparation of water extract of bee pollen: superfine pulverization of camellia pollen, lotus pollen or rape pollen, hot dipping in distilled water at 95°C for 3 hours, freeze-dried extract, and crushing through a 60-mesh sieve.

[0047] (3) Preparation of modified pectin: Pectin from sources such as citrus, carrot, silkworm excrement, and sunflower dish is subjected to alkaline hydrolysis (NaOH aqueous solution...

Embodiment 3

[0050] The preparation of embodiment 3 composition powder of the present invention (three)

[0051] The ratio of parts by weight of each natural product is: 1 g of propolis ethanol extract, 1 g of bee pollen water extract, 10 g of modified pectin powder, and 1 g of donkey-hide gelatin powder.

[0052] (1) Preparation of propolis ethanol extract: Chinese poplar propolis or Brazilian propolis raw materials were frozen and pulverized, refluxed and extracted with 75% ethanol solution at 70°C for 4 hours, and the extract was freeze-dried and pulverized through a 60-mesh sieve.

[0053] (2) Preparation of water extract of bee pollen: ultrafine pulverization of camellia pollen, lotus pollen or rape pollen, hot soaking in distilled water at 80°C for 4 hours, freeze-dried extract, and pulverizing through a 60-mesh sieve.

[0054] (3) Preparation of modified pectin: Pectin from sources such as citrus, carrot, silkworm excrement, and sunflower dish is subjected to alkaline hydrolysis (Na...

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Abstract

The invention relates to composition for preventing and treating osteoporosis as well as a preparation method and an application of the composition. The composition is prepared from the following rawmaterials in parts by weight: 1-20 parts of propolis alcohol extract, 1-20 parts of bee pollen water extract, 10-70 parts of modified pectin powder and 1-20 parts of colla corii asini powder, whereinthe propolis alcohol extract is prepared from a propolis raw material in a 70%-75% ethanol solution by reflux extraction for 2-4 h under the heating condition at 70-75 DEG C and by freeze-drying and pulverizing; the bee pollen water extract is prepared from a bee pollen raw material in distilled water by extraction for 2-4 h under the heating condition at 80-95 DEG C and by freeze-drying and pulverizing; the modified pectin powder is obtained from a pectin raw material by alkaline hydrolysis or enzymolysis and has molecular weight of 2,000-30,000 and esterification degree of 5%-35%. Cell, animal and clinical experiments prove that the composition has very obvious effect of preventing and treating osteoporosis.

Description

technical field [0001] The invention relates to the technical fields of medicine, health products and food, in particular to a composition for preventing and treating osteoporosis, a preparation method and application thereof. Background technique [0002] Osteoporosis is a silent disease that seriously affects the quality of life of the elderly. It has no obvious clinical symptoms in the early stage, and it is difficult to be discovered. Most of them are not intervened until fractures occur. There are more than 200 million osteoporosis patients in the world every year, and about 89 million osteoporosis patients suffer from fractures. According to the current prevalence rate of osteoporosis of 13%, the annual cost of fractures caused by osteoporosis is as high as 1 billion US dollars. With the advent of my country's aging society, the prevention and treatment of osteoporotic fractures has become an important social public health task. Therefore, the development of foods an...

Claims

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Application Information

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IPC IPC(8): A61K35/644A61K36/00A61P19/10A23L33/10A23L21/20A61K31/732A61K35/36A61K35/64
CPCA23L21/20A23L33/10A23V2002/00A61K31/732A61K35/36A61K35/63A61K35/64A61K35/644A61K36/00A61P19/10A61K2300/00A23V2200/306
Inventor 朱威李英华
Owner ZHEJIANG UNIV
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