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A photodynamic therapy diagnostic device capable of optical fiber puncture

A technology of photodynamic therapy and diagnostic device, which is applied in the field of medical devices, can solve the problems that the treatment effect and the accuracy of case studies are greatly affected, and achieve the effects of effective cooperation, high treatment effect, and elimination of vascular obstruction

Active Publication Date: 2019-11-15
尚华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the singlet oxygen production rate is generally analyzed by analyzing the residual fluorescence in the blood, and analysis after puncture sampling, etc., which cannot achieve rapid online detection, which has a great impact on the treatment effect and the accuracy of case studies.

Method used

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  • A photodynamic therapy diagnostic device capable of optical fiber puncture
  • A photodynamic therapy diagnostic device capable of optical fiber puncture
  • A photodynamic therapy diagnostic device capable of optical fiber puncture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A photodynamic therapy diagnostic device capable of optical fiber puncture, which includes an optical fiber puncture needle tube 10, a laser 14, an optical coupler 12 and a fluorescence analyzer 13, the optical fiber puncture needle tube includes an optical fiber, and the optical fiber includes a main body 8 and a puncture needle , one end of the main body 8 is connected with the puncture needle, and the other end of the main body is connected with the optical coupler 12, and the optical coupler 12 is connected with the laser 14 and the fluorescence analyzer 13 at the same time so that the laser light in the laser 14 can pass through The optical coupler 12 enters the optical fiber, and the fluorescence generated by the photosensitizer after absorbing the laser can enter the fluorescence analyzer 13 through the optical fiber and the optical coupler 12; figure 1 shown.

[0042] The puncture needle includes a straight head 1 and a tapered head 2. The front end or free end ...

Embodiment 2

[0062] On the basis of Embodiment 1, the main body tube 9 is a helical tube containing a plurality of helical coils, and the slit of the helical tube is a helical structure formed by laser cutting to form a helical slit.

[0063] Such as Figure 9 As shown, the Figure 9 It is a schematic view of the section of the main pipe 9, and is a view from the inside of the main pipe 9; in the main pipe 9, the width a of the slit is 0.02-0.2mm, such as 0.05, 0.08mm, 0.1mm, 0.15mm, etc. , the width d of the helical sheet forming the helical structure in the main tube 9 is 0.5-3 mm, such as 1 mm, and the thickness is 0.05-0.1 mm, such as 0.08 mm. The length of the main tube 9 is nearly 2 meters, and it usually has 1-1.8m to penetrate into the human body, and the blood vessels of the human body vary in thickness and have a certain degree of curvature. Such a long distance and such a special vascular environment affect its strength and The flexibility requirements are very high, so the wi...

Embodiment 3

[0068] On the basis of embodiment 1 or 2, such as Figure 17-20 As shown, the metal sheet that constitutes the helical structure of the metal jacket 4 is a barb-shaped structure, which has a small resistance when moving forward and a large resistance when retreating, so that it can be punctured in a progressive manner by applying a small impact , effectively reducing the pressure required for puncture.

[0069] The barb-shaped structure is: the thickness of the front end of the metal sheet 41 constituting the metal jacket 4 is smaller than the thickness of the rear end, so that the optical fiber puncture needle is easier to move forward and not easy to retreat.

[0070] More preferably, as Figure 20 As shown, because the thickness c of the front end of the metal sheet is too thin, it is not easy to mark its thickness in the drawings, so only the position of c is marked in the drawings, and the relationship of its thickness is not given. In the inverted-toothed structure of ...

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Abstract

The invention relates to a photodynamic therapy diagnosis device with a fiber puncture function, which comprises a fiber, a laser, a beam splitting coupler and a fluorescence analyzer. The fiber includes a main part and a puncture needle head. One end of the main part is connected with the puncture needle head, and the other end is connected with the beam splitting coupler. The beam splitting coupler is simultaneously connected with the laser and the fluorescence analyzer so that the laser in the laser can enter the fiber through the beam splitting coupler and the fluorescence generated by photosensitizer after laser absorbing can enter the fluorescence analyzer through the fiber and the beam splitting coupler. According to the therapy diagnosis device, the laser emits a photosensitizer drug to absorb wavelength laser, the laser passes through the beam splitting coupler and then enters a tumor site in the body through a fiber puncture needle tube, and red light kills tumor cells afterbeing absorbed by the photosensitizer drug in the tumor. The photosensitizer drug generates fluorescence after being stimulated, and the fluorescence enters the fluorescence analyzer through the beamsplitting coupler. The fluorescence quantum yield and the therapeutic effect can be analyzed according to the analysis result. An effect of synchronous treatment and diagnosis can be achieved.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a photodynamic therapy and diagnosis device capable of optical fiber puncture. Background technique [0002] Photodynamic therapy (Photodynamic Therapy, PDT) is a new technology that uses photodynamic effect for disease diagnosis and treatment. Its basis is the photodynamic effect. This is a photosensitization reaction accompanied by biological effects involving oxygen molecules. The process is that the photosensitizer absorbed by the tissue is excited by the laser irradiation of a specific wavelength, and the photosensitizer in the excited state transfers energy to the surrounding oxygen to generate highly active singlet oxygen, and the singlet oxygen and adjacent biological Oxidation of macromolecules produces cytotoxicity, which in turn leads to cell damage and even death. Compared with traditional therapy, photodynamic therapy has the advantages of less trauma, bet...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61N5/06A61B5/00
CPCA61B5/0071A61B5/0084A61B5/6849A61N5/062A61N2005/0612A61N2005/063
Inventor 尚华
Owner 尚华
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