Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Short lipopeptid with specific anti-propionibacterium acne effect and anti-inflammatory effect

A lipopeptide and acne technology, which can be applied to medical preparations containing active ingredients, peptides, hybrid peptides, etc., can solve the problems of secondary infection and poor specificity, and achieve low toxicity, low cost, and short amino acid sequence length. Effect

Active Publication Date: 2019-02-12
SOUTHERN MEDICAL UNIVERSITY
View PDF2 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Secondly, most of these peptides have broad-spectrum antibacterial activity, and their specificity is poor. When used, they may also kill beneficial bacteria in the human body, resulting in secondary infection

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Short lipopeptid with specific anti-propionibacterium acne effect and anti-inflammatory effect
  • Short lipopeptid with specific anti-propionibacterium acne effect and anti-inflammatory effect
  • Short lipopeptid with specific anti-propionibacterium acne effect and anti-inflammatory effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1.1 Experimental method

[0041] 1.1.1 Polypeptide synthesis

[0042] Peptides were synthesized by solid phase synthesis using amide MHBA resin and standard 9-fluorenylmethoxycarbonyl (Fmoc) amino acids. Peptide extension reaction conditions are as follows: standard HBTU / HOBt used as coupling agent, N-dimethylformamide as solvent, 10-fold excess of diisopropylethylamine, 3-fold excess of Fmoc protecting group amino acid or 5-fold excess of free fatty acids. The peptide was cleaved from the resin using a reagent consisting of 87.5% trifluoroacetic acid, 2.5% ethanedithiol, 5% thioanisole, and 5% deionized water, and reacted for 3 hours at room temperature, after which the peptide was exposed to methyl tert-butyl Precipitate in ether-petroleum ether (volume ratio 1:1). The molecular weight of the peptide was confirmed by electrospray ionization mass spectrometry (ESI-MS, Waters, USA). The purity of the peptide was analyzed on a C18 column (250×4.6mm; Shimadzu, Kyoto, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
melting pointaaaaaaaaaa
concentrationaaaaaaaaaa
Login to View More

Abstract

The invention discloses short lipopeptid with a specific anti-propionibacterium acne effect and an anti-inflammatory effect, and belongs to the technical field of biology. The short lipopeptid is prepared from C6-C20 fatty acids and an amino acid sequence with a general formula of KWKW. The short lipopeptid can specifically inhibit growth of propionibacterium acnes, and reduce inflammatory response of tissues surrounding hair follicles, and in vitro and in vivo experiments show that the short lipopeptid has high antibacterial and anti-inflammatory activity, and low toxicity; moreover, the short lipopeptid has an action mechanism different from those of traditional antibiotics, resistance to the short lipopeptid is hard to generate, and the short lipopeptid is especially effective for bacterial strains which already generate resistance to the existing antibiotics so that the fundamental purposes of controlling acnes and improving the living quality can be achieved. The short lipopeptidis a compound or complex prepared from lipids and amino acid, can be added into various kinds of wash supplies or make-up, is safe and environmentally friendly, and has wide market prospects.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a short lipopeptide with specific anti-Propionibacterium acnes action and anti-inflammatory action. Background technique [0002] Acne is a common chronic inflammatory skin disease of the pilosebaceous glands in teenagers. It occurs mostly in the head, face, neck and other parts rich in sebaceous glands. In severe cases, skin cancer may also form; (2) It may lead to the formation of acne spots, acne pits, acne scars, etc., affecting young people's career choice, spouse selection, and communication, causing adolescent depression, withdrawn personality, low self-esteem, and affecting the patient's mental health . One of the main pathogenic factors causing acne is Propionibacterium acnes, and moderate to severe inflammatory lesions are currently treated with systemic or topical antibiotics. However, traditional antibiotics are easy to make bacteria resistant, leading to a ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/09A61K38/07A61P17/10A61K8/64A61Q19/10A61Q19/00
CPCA61K8/64A61K38/00A61Q19/00A61Q19/10A61P17/10C07K5/0815C07K19/00
Inventor 何坚杨光王静瑜
Owner SOUTHERN MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com