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Preparation method for cobalt-based nitride sensor for detecting praziquantel, and application

A technology of praziquantel and nitride, which is applied in the field of preparation of electrochemical sensors, can solve the problems of reduced sensitivity, reduced stability and reproducibility of electrochemical sensors, and restrictions on the application of molecularly imprinted membranes, and achieves excellent electron transfer capabilities, Ease of operation and reduced testing costs

Inactive Publication Date: 2019-01-22
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the preparation process of traditional MIP-ECS, there are disadvantages such as difficult elution of template molecules, difficulty in controlling the thickness of imprinted membranes, and poor reproducibility, which limit the application of molecularly imprinted membranes in electrochemical sensors.
These problems, especially the difficult control of the thickness of the molecularly imprinted membrane, which leads to the decrease of the sensitivity of the electrochemical sensor, and the technical difficulties that the molecularly imprinted membrane is easily detached from the electrode surface during the elution process, resulting in a decrease in stability and reproducibility, limit the application of MIP_ECS. It is of great research significance and market value to find new synthesis methods for molecularly imprinted polymers, new methods for modifying molecularly imprinted membrane electrodes, and methods for combining molecularly imprinted membranes with substrate materials to solve the problems of preparation and application of MIP-ECS.

Method used

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  • Preparation method for cobalt-based nitride sensor for detecting praziquantel, and application
  • Preparation method for cobalt-based nitride sensor for detecting praziquantel, and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Preparation of CoN-nanoarray

[0030] (1) Use dilute hydrochloric acid, absolute ethanol and deionized disposable electrode for ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0031] (2) Weigh 1 mmol cobalt nitrate hexahydrate Co(NO 3 ) 2 ·6H 2 O and 3 mmol urea CO(NH 2 ) 2 , put it into a 50 mL beaker, add 30 mL of deionized water and stir until clear, then transfer to a 50 mL polytetrafluoroethylene reactor;

[0032] (3) Put the disposable disposable electrode treated in step (1) into the solution in the reaction kettle in step (2), and react at a temperature of 100°C for 12 hours to prepare the cobalt hydroxide nanosheet array precursor body electrode;

[0033] (4) Insert the cobalt hydroxide nanosheet array precursor electrode obtained in step (3) into ammonia water for 5 seconds, take it out, and heat it to 340°C for 8 hours in an ammonia environment, then continue to naturally Cool down to room t...

Embodiment 2

[0035] Example 2 Preparation of CoN-nanoarray

[0036] (1) Use dilute hydrochloric acid, absolute ethanol and deionized disposable electrode for ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0037] (2) Weigh 2 mmol cobalt nitrate hexahydrate Co(NO 3 ) 2 ·6H 2 O and 6 mmol urea CO(NH 2 ) 2 , put it into a 50 mL beaker, add 30 mL of deionized water and stir until clear, then transfer to a 50 mL polytetrafluoroethylene reactor;

[0038] (3) Put the disposable disposable electrode treated in step (1) into the solution in the reaction kettle in step (2), and react at a temperature of 110°C for 11 hours to prepare the cobalt hydroxide nanosheet array precursor body electrode;

[0039] (4) Insert the cobalt hydroxide nanosheet array precursor electrode obtained in step (3) into ammonia water for 15 seconds, take it out, and heat it to 370°C for 6 hours in an ammonia environment, then continue to naturally Cool down to room ...

Embodiment 3

[0041] Example 3 Preparation of CoN-nanoarray

[0042] (1) Use dilute hydrochloric acid, absolute ethanol and deionized disposable electrode for ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0043] (2) Weigh 3 mmol cobalt nitrate hexahydrate Co(NO 3 ) 2 ·6H 2 O and 9 mmol urea CO(NH 2 ) 2 , put it into a 50 mL beaker, add 30 mL of deionized water and stir until clear, then transfer to a 50 mL polytetrafluoroethylene reactor;

[0044] (3) Put the disposable disposable electrode treated in step (1) into the solution in the reaction kettle in step (2), and react at a temperature of 130°C for 9 hours to prepare the cobalt hydroxide nanosheet array precursor body electrode;

[0045] (4) Insert the cobalt hydroxide nanosheet array precursor electrode obtained in step (3) into ammonia water for 30 seconds, take it out, heat it to 400°C and keep it for 4 hours in an ammonia environment, and then continue to naturally Cool do...

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Abstract

The invention discloses a preparation method for a cobalt-based nitride sensor for detecting praziquantel, and application, and belongs to the technical field of novel nanometer function materials andchemical biosensors. The preparation method firstly prepares a cobalt nitride nanosheet array on a disposable electrode, the large specific surface area of the cobalt nitride nanosheet array and highadsorption activity for an amino are used for successively directly preparing a polydopamine film containing an electronic mediator and a molecularly imprinted polymer which takes a praziquantel molecule as a template molecule on the cobalt nitride nanosheet array through an in-situ growth method, and after the template molecule is eluted, the position of the original template molecule becomes acavity, i.e., the molecularly imprinted polymer of the template molecule is eluted. Therefore, the cobalt-based nitride sensor for detecting praziquantel finishes being prepared.

Description

technical field [0001] The invention relates to a preparation method and application of an electrochemical sensor. It belongs to the technical field of new nano functional materials and chemical biosensors. Background technique [0002] Praziquantel is an anthelmintic for humans and animals, specifically for the treatment of tapeworms and flukes. However, due to its high toxicity, the drug must be used strictly according to the requirements. Otherwise, it may cause dizziness, headache, nausea, abdominal pain, diarrhea, fatigue, sore limbs, etc. In severe cases, symptoms such as palpitations and chest tightness may occur, and occasionally it may induce mental disorders or gastrointestinal bleeding. Animals must be slaughtered for more than 5 to 7 days during the drug withdrawal period. When people eat animal food with such anthelmintic residues, the drug toxicity will also be transferred to humans, thus endangering human health. At present, the methods for detecting prazi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/26G01N27/30G01N27/327
CPCG01N27/26G01N27/30G01N27/3278
Inventor 刘召壹张勇杜斌
Owner UNIV OF JINAN
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