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Antibacterial agent for suture line of surgical operation and preparation method of antibacterial agent

A technique for surgical operations and sutures, which is applied in the fields of surgery, surgical instruments, medical science, etc., can solve the problems of poor biocompatibility, physical health damage, and reduced antibacterial performance, and achieves low cost of preparation, safe and environmentally friendly use, The effect of preventing leakage

Inactive Publication Date: 2019-01-22
湖南博隽生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing antibacterial agents include two types of inorganic antibacterial agents and organic antibacterial agents. Due to poor biocompatibility, inorganic antibacterial agents are not easy to disperse evenly. After being added to surgical sutures, they are prone to extravasation during use. The antibacterial performance is greatly reduced
The organic antibacterial agents in the prior art are highly toxic, and while having antibacterial and bactericidal effects, they have brought other harm to the health of the surgeon

Method used

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  • Antibacterial agent for suture line of surgical operation and preparation method of antibacterial agent

Examples

Experimental program
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Effect test

Embodiment 1

[0026] A preparation method for an antibacterial agent for surgical sutures, comprising the steps of:

[0027] Ⅰ Preparation of silver chlorolactate compounds: Add 21.3g of silver lactate and 10g of epichlorohydrin into 100g of tetrahydrofuran, stir for 15 minutes, then add 4g of sodium carbonate, stir and react at 95°C for 8 hours, and cool to At room temperature, filter, and remove the solvent by rotary evaporation to obtain silver chlorolactate compounds;

[0028] Ⅱ5-(4-Chlorobutyl)hydantoin modified chitosan: Dissolve 30g of chitosan and 5g of 5-(4-chlorobutyl)hydantoin in 100g of acetic acid, and add tetrabutyl bromide to it Ammonium 7g was stirred and reacted at 40°C for 6 hours, cooled to room temperature after the reaction was completed, acetic acid was removed by rotary evaporation, water was added thereto, suction filtered, and finally placed in a vacuum oven at 90°C for 10 hours to obtain 5-( 4-chlorobutyl) hydantoin modified chitosan;

[0029] III Silver ion dopi...

Embodiment 2

[0033] A preparation method for an antibacterial agent for surgical sutures, comprising the steps of:

[0034] Ⅰ Preparation of silver chlorolactate compounds: Add 21.3g of silver lactate and 10g of epichlorohydrin to 115g of tetrahydrofuran, stir for 16 minutes, then add 4.5g of potassium carbonate, stir and react at 97°C for 8.5 hours, cool to room temperature, filtered, and the solvent was removed by rotary evaporation to obtain silver chlorolactate compounds;

[0035] Ⅱ 5-(4-chlorobutyl)hydantoin modified chitosan: Dissolve 35g of chitosan and 6g of 5-(4-chlorobutyl)hydantoin in 115g of formic acid, and add 1-butyl- 7g of 3-methylimidazolium tetrafluoroborate, stirred and reacted at 45°C for 6.5 hours, cooled to room temperature after the reaction, rotary evaporated to remove formic acid, then added water to it, suction filtered, and finally placed in a vacuum drying oven at 93°C Bake down for 12 hours to obtain 5-(4-chlorobutyl) hydantoin modified chitosan;

[0036] III...

Embodiment 3

[0040] A preparation method for an antibacterial agent for surgical sutures, comprising the steps of:

[0041] Ⅰ Preparation of silver chlorolactate compounds: Add 21.3g of silver lactate and 10g of epichlorohydrin into 125g of tetrahydrofuran, stir for 18 minutes, then add 5g of sodium hydroxide, stir and react at 99°C for 9 hours, cool to room temperature, filtered, and the solvent was removed by rotary evaporation to obtain silver chlorolactate compounds;

[0042]Ⅱ 5-(4-chlorobutyl) hydantoin modified chitosan: Dissolve 40g of chitosan and 7.5g of 5-(4-chlorobutyl)hydantoin in 130g of benzoic acid, and add tetrabutyl Ammonium bromide 7g, stirred and reacted at 50°C for 7 hours, cooled to room temperature after the reaction, benzoic acid was removed by rotary evaporation, water was added thereto, suction filtered, and finally placed in a vacuum drying oven at 95°C for 13 hours to obtain 5-(4-Chlorobutyl)hydantoin modified chitosan;

[0043] III Silver ion doping: 40 g of 5...

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Abstract

The invention discloses a preparation method of an antibacterial agent for a suture line of surgical operation. The preparation method comprises the following steps: (1) preparing a chloro silver lactate compound; (2) preparing chitosan modified by 5-(4-chlorobutyl) hydantoin; and (3) doping silver ions. The invention further discloses the antibacterial agent for the suture line of surgical operation which is prepared by adopting the preparation method and the suture line of the surgical operation which adopts the antibacterial agent for the suture line of surgical operation as the antibacterial treatment agent. The antibacterial agent for the suture line of surgical operation disclosed by the invention is low in preparation price, obvious in antibacterial effect, good in compatibility with the suture line of the surgical operation, good in stability of the antibacterial property, and safe and environmentally friendly in use.

Description

technical field [0001] The invention belongs to the technical field of surgical equipment, and relates to a treatment agent for common surgical sutures, in particular to an antibacterial agent for surgical sutures and a preparation method thereof. Background technique [0002] In recent years, with the increasing pressure of life and work and the deterioration of the ecological environment, various diseases linger around people. These diseases have brought great suffering to people, and their treatment is a problem that people have to face. Some comparatively serious diseases need surgical treatment, and in the surgical treatment process, a kind of requisite equipment is surgical suture thread. Surgical suture is a special thread used for hemostasis and suture hemostasis and tissue suture in surgical operation or trauma treatment. Generally, it can be divided into absorbable thread and non-absorbable thread. Although these surgical sutures have been subjected to high-temper...

Claims

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Application Information

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IPC IPC(8): A61L17/00A61L17/10
CPCA61L17/005A61L17/10A61L2300/104A61L2300/208A61L2300/232A61L2300/404
Inventor 朱露晶
Owner 湖南博隽生物医药有限公司
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