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A medical chitosan nanosphere loaded with menaquinone-4 for the treatment of spinal cord injury and its preparation method

A menaquinone and spinal cord injury technology, applied in the field of medical materials, can solve the problems of no surgery, secondary spinal cord injury, etc., and achieve the effects of ensuring activity, improving biocompatibility, and promoting cell survival

Active Publication Date: 2020-09-01
THE FIRST PEOPLES HOSPITAL OF NANTONG
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the deficiencies of the prior art, the present invention provides a medical chitosan nanosphere loaded with menaquinone-4 for the treatment of spinal cord injury and its preparation method, which solves the problem that there is currently no effective surgical operation and medicine to treat spinal cord injury. Secondary Injury Problems

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  • A medical chitosan nanosphere loaded with menaquinone-4 for the treatment of spinal cord injury and its preparation method
  • A medical chitosan nanosphere loaded with menaquinone-4 for the treatment of spinal cord injury and its preparation method
  • A medical chitosan nanosphere loaded with menaquinone-4 for the treatment of spinal cord injury and its preparation method

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Embodiment Construction

[0035] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0036] see Figure 1-4 , the present invention provides a technical solution: a medical chitosan nanosphere loaded with menaquinone-4 for the treatment of spinal cord injury and a preparation method thereof, comprising the following steps,

[0037] 1. Measure 9.8mL of medical paraffin oil, drain it with a glass rod, slowly add it into the round bottom flask, then add 0.2ml of Span-80, and ultrasonically stir for 2 hours to mix the liquid in the round bottom fl...

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Abstract

The invention discloses a medical chitosan nanosphere carrying methylnaphthoquinone-4 for treating spinal cord injury and a preparation method thereof, and relates to the field of medical materials. The medical chitosan nanosphere is made of the following components, 2% Span- 80 paraffin oil is 1-20mL, 5% medical chitosan physiological balance solution is 0.1-5mL, methyl naphthoquinone-4 is 1-20mgand 10% polyethylene glycol 2000 solution is 10- 100 [mu]L. The preparation method comprises the following steps: preparing an oil phase; preparing an aqueous phase, using 1 ml of a 5% medical chitosan physiological balance solution as an aqueous phase, and adding 10 mg of methylnaphthoquinone-4 to the aqueous phase, stirring using an ultrasonic stirrer 1h; mixing, pipetting the aqueous phase with a 1 mL pipette and slowly adding to the oil phase, stirring with an ultrasonic stirrer; stirring; centrifugation; initial cleaning; secondary cleaning; three cleanings; The medical chitosan nanospheres for treating spinal cord injury containing menaquinone-4 and the preparation method thereof solve the problem that there is no effective surgery and the medicine can treat the secondary injury ofthe spinal cord.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a medical chitosan nanosphere loaded with menaquinone-4 for treating spinal cord injury and a preparation method thereof. Background technique [0002] The technique of preparing microspheres from polymers has been widely used in controlled protein drug delivery systems. Studies have found that microspheres can protect lipid drugs, increase their stability, avoid oxidation during administration, increase their water solubility, improve bioavailability, prolong the release time of lipid drugs, and protect their lipids. active. Then increase the efficacy and reduce the toxicity of metabolites to the kidneys. [0003] Chitosan is a natural polymer polysaccharide that widely exists in nature. It is generally extracted from the shells of crustaceans such as shrimps and crabs, so it is also called chitin. Medical chitosan is currently a star active in the field of biomedicine. Moder...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K9/51A61K47/36A61K47/10A61K31/122A61P25/00
CPCA61K9/5146A61K9/5161A61K31/122A61P25/00
Inventor 徐大伟王成牛盛美红韩云崔志明
Owner THE FIRST PEOPLES HOSPITAL OF NANTONG
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