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Application of alkali metal salts of rutin in prevention and treatment of fatty liver

An alkali metal salt and fatty liver technology, which is applied in the field of medicine, can solve the problems of unclear pharmacokinetics, poor water solubility, and poor drug absorption effect, and achieve the effects of reducing serum total cholesterol content, reducing liver fat accumulation, and improving absorption effect

Inactive Publication Date: 2019-01-11
南京昂科利医药科技创新研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Troxerutin has poor water solubility, and the drug absorption effect is worse than that of the present invention
Because of its poor solubility in water and unclear pharmacokinetics, it is currently only used as an auxiliary drug in the treatment of other diseases

Method used

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  • Application of alkali metal salts of rutin in prevention and treatment of fatty liver
  • Application of alkali metal salts of rutin in prevention and treatment of fatty liver
  • Application of alkali metal salts of rutin in prevention and treatment of fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0023] Sodium rutin prevents the occurrence of fatty liver in the aging process

[0024] Older mice develop liver fat accumulation during aging, in part mimicking the development of fatty liver.

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Abstract

The invention discloses an application of alkali metal salts of rutin in prevention and treatment of fatty liver. When rutin C7-OH is subjected to a substitution reaction of alkali metals such as Li,Na, K, Rb or Cs and the like, alkali metal salts of rutin are produced, the water solubility is improved by 200 times or higher, and the absorption effect of the drug is obviously improved, so that the in-vivo effective drug concentration is increased by about 200 times. Animal experiments show that the alkali metal salts of rutin are capable of obviously reducing the liver fat accumulation and total cholesterol content in serum.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of alkali metal salts of rutin in the prevention and treatment of fatty liver. Background technique [0002] Fatty liver (fatty liver) is a reversible disease of excessive fat accumulation. The main causes of the disease are excessive alcohol intake, obesity and lipid metabolism disorders caused by other diseases. Fatty liver disease is seriously threatening the health of the Chinese people, becoming the second largest liver disease after viral hepatitis, the incidence rate is constantly increasing, and the age of onset is getting younger. At present, there is no specific drug for the prevention and treatment of fatty liver. The development of effective specific drugs is still an urgent problem to be solved. [0003] The research and development of drugs for fatty liver is mainly based on blood lipid-lowering drugs, bile-protecting and liver-protecting drugs, and cytoki...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P1/16A61P3/06
CPCA61K31/7048A61P1/16A61P3/06
Inventor 廖亚金
Owner 南京昂科利医药科技创新研究院有限公司
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