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A preparation method of nanoparticles loaded with two anti-liver cancer drugs and having double-layer controlled release-photothermal-targeting function

A nanoparticle, anti-cancer technology, applied in non-active ingredients medical preparations, medical preparations containing active ingredients, drug combinations, etc. Efficiency, prolonged drug action time, and easy storage effects

Active Publication Date: 2021-04-02
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods all have great risks, which are likely to bring great trauma and complications to patients, and at the same time, they are likely to cause great damage to normal cells while killing cancer cells.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1) Add 2 g of Span 80 and Op 10 into 200 mL of cyclohexane, stir for 5 min, seal and place in a 1°C environment for pre-cooling;

[0040] 2) Take 0.18 g NaHSO3 Add 10 mL of deionized water to prepare a solution, seal it and place it in an environment of 1°C to pre-cool it for later use;

[0041] 3) Take 4 g of acrylamide and 0.22 g of K 2 S 2 o 8 Add 45 mL of deionized water, stir until dissolved, pour into the solution in step 1), stir at high speed, rapidly raise the temperature to 55 °C under the protection of nitrogen, and slowly add NaHSO in step 2) to the solution dropwise 3 After reacting for 4 h, the pH of the solution was adjusted to 6 with NaOH. Pour the product into a methanol solution for precipitation, then filter, wash with acetone, dry the filtrate at 40 °C for 10 h, grind it finely to obtain polyacrylamide particles, and put it in a desiccator for later use;

[0042] 4) Dissolve 2 g of carboxymethyl chitosan and 1 g of carboxymethyl pullulan in 100 m...

Embodiment 2

[0054] 1) Add 2.5 g of Span 80 and Op 10 into 225 mL of cyclohexane, stir for 6 min, seal and place in a 3°C environment for pre-cooling;

[0055] 2) Take 0.19 g NaHSO 3 Add 12 mL of deionized water to prepare a solution, seal it and place it in a 3°C environment for pre-cooling;

[0056] 3) Take 4.5 g acrylamide and 0.24 g K 2 S 2 o 8 Add 47 mL of deionized water, stir until dissolved, pour into the solution in step 1), stir at high speed, rapidly raise the temperature to 55 °C under the protection of nitrogen, and slowly add NaHSO in step 2) to the solution dropwise 3 solution, after reacting for 4.5 h, the pH was adjusted to 7 with NaOH. Pour the product into a methanol solution for precipitation, then filter, wash with acetone, dry the filtrate at 40 °C for 11 h, and grind it finely to obtain polyacrylamide particles, which are put into a desiccator for later use;

[0057] 4) Dissolve 2.5 g of carboxymethyl chitosan and 1.5 g of carboxymethyl pullulan in 125 mL of dei...

Embodiment 3

[0069] 1) Add 3 g of Span 80 and Op 10 into 250 mL of cyclohexane, stir for 7 min, seal and place in a 5°C environment for pre-cooling;

[0070] 2) Take 0.2 g NaHSO 3 Add 15 mL of deionized water to prepare a solution, seal it and place it in an environment of 5°C to pre-cool it for later use;

[0071] 3) Take 5 g acrylamide and 0.25 g K 2 S 2 o 8 Add 50 mL of deionized water, stir until dissolved, pour into the solution in step 1), stir at high speed, rapidly raise the temperature to 55 °C under the protection of nitrogen, and slowly add NaHSO in step 2) to the solution dropwise 3 After reacting for 5 h, the pH of the solution was adjusted to 8 with NaOH. Pour the product into a methanol solution for precipitation, then filter, wash with acetone, dry the filtrate at 40 °C for 12 h, and grind it finely to obtain polyacrylamide particles, which are placed in a desiccator for later use;

[0072] 4) Dissolve 2-3 g of carboxymethyl chitosan and 2 g of carboxymethyl pullulan i...

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Abstract

The invention relates to a preparation method of a nano-particle loaded with two anti-hepatoma medicines and provided with a two-layer controlled release-light heat-target function. The method includes the steps: modifying carboxymethyl Pulullan on carboxymethyl chitosan by taking hydrophilic polyacrylamide as a bridge, and enabling the carboxymethyl chitosan to have a target function when the hydrophilcity of the carboxymethyl chitosan is improved; loading doxorubicin serving as an anti-cancer drug on polydopamine, wrapping the doxorubicin with hydrophilic polyvinylpyrrolidone and Arabic gum,loading Sorafenib serving as an anti-cancer drug on the outer surface of an oil phase of the hydrophilic polyvinylpyrrolidone and the Arabic gum, and wrapping a system with carboxymethyl chitosan-polyacrylamide-carboxymethyl Pulullan nano-particle water solution to obtain the nano-particle loaded the two anti-hepatoma medicines and provided with the two-layer controlled release-light heat-targetfunction. The polymer nano-particle can control release of the two-layer anti-hepatoma medicines and is combined with a light heat performance of the polydopamine to treat a liver cancer.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a method for preparing nanoparticles loaded with two anti-liver cancer drugs and having double-layer controlled release-photothermal-targeting functions. Background technique [0002] As a major disease that threatens human life and health, cancer has long been characterized by low cure rate, high recurrence and high mortality. Liver cancer is one of the most common malignant tumors in my country. In 2011, the incidence of liver cancer in China was about 356,000, the incidence rate was 26.39 / 100,000, and the standardized rate of Chinese population was 19.48 / 100,000. At present, surgery, radiotherapy, and chemotherapy are the main means and methods of cancer treatment. These methods all have great risks, and are likely to cause major trauma and complications to patients. At the same time, they are likely to cause greater damage to normal cells while killing cancer cells. In order to imp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K41/00A61K31/704A61K31/44A61K47/36A61K47/32A61K47/34A61P35/00
CPCA61K9/5138A61K9/5146A61K9/5161A61K9/5192A61K31/44A61K31/704A61K41/0052A61P35/00A61K2300/00
Inventor 王秉金小康胡锦华万军民胡智文
Owner ZHEJIANG SCI-TECH UNIV
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