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Preparation method of high-bulk-density L-cystine

A technology of cystine and bulk density, which is applied in the preparation of organic compounds, organic chemical methods, chemical instruments and methods, etc., can solve the problems of rough parameter control, achieve reduced packaging volume, ideal purity and yield, and reduce transportation cost effect

Active Publication Date: 2019-01-01
湖北远大生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process parameter control is relatively rough, the bulk density of L-cystine is usually around 0.3g / ml-0.5g / ml, and how to improve the bulk density of L-cystine has always been a problem to be solved by those skilled in the art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Add 120.6kg of crude L-cystine to 600L RO water and 110L hydrochloric acid, stir until completely dissolved, then add 3kg of activated carbon, stir and decolorize at 70°C for 15min, then filter through a 0.2um filter element; divide the filtrate evenly There are 3 parts, one part is pumped into the crystallization tank, add RO water to 2990L, heat up to 70°C and keep warm, adjust the rotation speed of the stirring paddle to 120rpm, adjust the flow rate of the peristaltic pump to 120L / h, and titrate the pH of the solution with 4% ammonia water To 3.5 as the end point, slowly add another portion of filtrate, and titrate the pH to 3.5 as the end point in the same way; operate the third portion in the same way; cool to 28°C, filter or centrifuge, and dry to obtain the finished L-cystine. The bulk density of L-cystine obtained in this example was measured to be 0.85 g / ml.

Embodiment 2

[0038] Add 119.5kg of crude L-cystine to 600L RO water and 118L hydrochloric acid, stir until completely dissolved, then add 3kg of activated carbon, stir and decolorize at 70°C for 15 minutes, then filter through a 0.2um filter element; divide the filtrate evenly There are 4 parts, one part is pumped into the crystallization tank, add RO water to 3010L, heat up to 70°C and keep it warm, adjust the rotation speed of the stirring paddle to 150rpm, adjust the flow rate of the peristaltic pump to 120L / h, and titrate the pH of the solution with 4% ammonia water To 3.5 as the end point, slowly add another part of the filtrate, and titrate the pH to 3.5 as the end point in the same way; operate the third and fourth parts in the same way; cool to 25°C, filter or centrifuge, and dry to obtain the finished L-cystine. The bulk density of L-cystine obtained in this example was measured to be 0.87 g / ml.

Embodiment 3

[0040] Add 124.0kg of crude L-cystine to 600L RO water and 124L hydrochloric acid, stir until completely dissolved, then add 3kg of activated carbon, stir and decolorize at 70°C for 15min, then filter through a 0.2um filter element; divide the filtrate evenly There are 3 parts, one part is pumped into the crystallization tank, add RO water to 3030L, heat up to 70°C and keep warm, adjust the rotation speed of the stirring paddle to 120rpm, adjust the flow rate of the peristaltic pump to 150L / h, and titrate the pH of the solution with 4% ammonia water To 3.5 as the end point, slowly add another portion of filtrate, and titrate the pH to 3.5 as the end point in the same way; operate the third portion in the same way; cool to 26°C, filter or centrifuge, and dry to obtain the finished L-cystine. The bulk density of L-cystine obtained in this example was measured to be 0.81 g / ml.

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PUM

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Abstract

The invention discloses a preparation method of high-bulk-density L-cystine. The preparation method comprises the following steps: adding an L-cystine crude product into a little RO water and certainvolume of hydrochloric acid until the L-cystine crude product is completely dissolved, adding active carbon to discolour, dividing into a plurality of parts after filtering, wherein one part is addedwith RO water to target volume; under a heat-preserving and stirring condition, titrating to the final point with special ammonia water concentration and special titrating speed, slowly adding the rest of filtrate, titrating to the final point according to the same method until each part of discoloured filtrate is titrated to the final point, filtering or centrifuging and drying to obtain the L-cystine finished product after cooling. The L-cystine obtained by the method has bulk density stabilized between 0.8g / ml and 0.9g / ml, and can reduce packaging volume of the product, so that the import and export transportation cost is reduced.

Description

technical field [0001] The invention relates to the field of amino acid preparation, in particular to a preparation method of high bulk density L-cystine. Background technique [0002] Bulk density, also known as bulk density, is defined in the United States Pharmacopoeia and European Pharmacopoeia as "refers to the volume measured in a visual measuring cylinder after a powder sample of a known substance is sieved or placed in a volume measurement The volume is measured in the cup to calculate the bulk density". [0003] In industrial production, light powders or crystals have a small bulk density, heavy powders or crystals have a large bulk density, particles with a small bulk density have a large porosity, and particles with a large bulk density have a small porosity. The higher bulk density can not only reduce the volume of product import and export packaging, thereby reducing transportation costs, but also meet the needs of different customers for product specifications...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C319/28C07C323/58
CPCC07B2200/07C07C319/28C07C323/58
Inventor 彭小亮赵东明胡志凤林添雄欧阳晖
Owner 湖北远大生物技术有限公司
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