Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Application of desmodium triflorum herb total flavonoid extract in preparation of drugs for preventing/treating ulcerative colitis

A technology of three-point gold and total flavonoids, applied in the field of medicine, to achieve the effect of improving intestinal tissue inflammatory infiltration and significant therapeutic effect

Active Publication Date: 2019-01-01
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention relates to the action and efficacy of Sandianjin total flavonoids extract in anti-ulcerative colitis, and no related reports have been seen yet

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of desmodium triflorum herb total flavonoid extract in preparation of drugs for preventing/treating ulcerative colitis
  • Application of desmodium triflorum herb total flavonoid extract in preparation of drugs for preventing/treating ulcerative colitis
  • Application of desmodium triflorum herb total flavonoid extract in preparation of drugs for preventing/treating ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Preparation of Sandianjin total flavonoids extract:

[0038] (1) Crush the dried aerial part of Sandianjin plant into powder, add 80-90% ethanol which is 1~3 times the mass volume (g / ml) of powder of the aerial part of Sandianjin plant, and soak for 48 hours after ultrasonication for 30 minutes; 2-3 times, collect the filtrate after filtration;

[0039] (2) Concentrate the filtrate prepared in (1) under reduced pressure until it has no ethanol smell, add distilled water 1 times the volume / volume (ml / ml) to suspend, which is the water phase;

[0040] (3) Add petroleum ether solvent of 1 times the volume / volume (ml / ml) to the water phase in (2), extract and soak for 12 hours, discard the petroleum ether phase, and keep the water phase;

[0041] (4) Add ethyl acetate solvent of 1 times the volume / volume (ml / ml) to the water phase in (3) to extract and soak for 12 hours, collect the ethyl acetate phase, concentrate under reduced pressure until there is no ethyl acetate sol...

Embodiment 2

[0047] Observation on the efficacy of Sandianjin total flavonoids extract on UC mouse model

[0048] Experimental medication The total flavonoid extract of Sandianjin was obtained from Example 1.1 of the present invention.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of a desmodium triflorum herb total flavonoid extract in the preparation of drugs for preventing / treating ulcerative colitis. An experiment proves that the desmodium triflorum herb total flavonoid extract can effectively improve the pathological change of ulcerative colitis model mouse intestinal tissues. By reducing the number of ILC3s cells in colon tissues, the desmodium triflorum herb total flavonoid extract can also inhibit the expression of the upstream regulatory factor IL-1Beta and the downstream IL-17A and promote the expression of IL-10 and IL-22 in the intestinal tissues, thus exerting the effect of treating ulcerative colitis. The desmodium triflorum herb total flavonoid extract has an application prospect in treating ulcerative colitis disease.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of Sandianjin total flavonoid extract in the preparation of medicines for preventing / treating ulcerative colitis. Background technique [0002] Ulcerative colitis (UC) is a digestive tract disease characterized by chronic inflammation and ulceration of the colonic mucosa, clinically manifested as hemorrhagic diarrhea, abdominal pain, and vomiting. Inflammatory bowel disease is more common in people aged 30 to 40. In recent years, the incidence of inflammatory bowel disease has shown a trend of global spread, showing that the incidence rate is increasing in many regions, especially in Asia, the Middle East and South America. Ulcerative colitis has complex etiology, multiple stages of pathogenesis, difficult cure, recurrent attacks, and is closely related to the incidence of colon cancer. It is listed by the World Health Organization as one of the moder...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P1/04A61P1/00
CPCA61K36/48A61K2236/15A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61P1/00A61P1/04
Inventor 李艳平何红平王亭汪伟光黄丰杨芬
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com