Dialysis tube built-in type blood hemodialysis system

Abstract

The invention discloses a dialysis tube built-in type blood hemodialysis system. The system comprises a dialysis container, a dialysis tube, a power pump and a collecting vat which are sequentially connected. The dialysis tube comprises a dialysis outer tube, a dialysis inner tube and a dialysis film. The outer wall of the dialysis inner tube is coated with the dialysis film, the dialysis container is connected to a liquid inlet through a liquid inflow tube, and the power pump is connected to a liquid outlet through a liquid outflow tube. The dialysis tube comprises a fixed base and a jacket,the fixed base is a hollow cylinder, the jacket is clamped on the outer side wall of the fixed base, and holes corresponding in position are formed in the outer side wall of the fixed base and the jacket. During use, the dialysis film is spread and clamped between the outer side wall of the fixed base and the jacket. A first magnetic stirrer is mounted at the inner bottom of the fixed base. By theadoption of the dialysis tube built-in type blood hemodialysis system, the dialysis efficiency is improved, and by means of a dialysis film fixing device, a sample can be kept in a sterile state in the dialysis and transfer processes.

Description

technical field [0001] The invention relates to the technical field of hemodialysis, more specifically, it relates to a hemodialysis system with a built-in dialysis tube. Background technique [0002] The core component of dialysis technology is the dialysis membrane. The dialysis membrane with micropores allows molecules smaller than the diameter of the micropores to diffuse to the other side of the dialysis membrane, so that dialysis can proceed. Dialysis is one of the commonly used techniques in the laboratory, which is used for the replacement of buffer systems, crude purification, concentration, desalination, etc. of macromolecular substances such as proteins. [0003] At present, the laboratory generally uses dialysis membranes made of cellulose, mixed cellulose and other materials. The dialysis membranes are made into dialysis bags and dialysis tubes. During dialysis, the sample liquid is put into them, sealed and placed in the dialysate for dialysis. Dialysis bags a...

AI Technical Summary

Problems solved by technology

However, the movement mode of the sample molecules in the dialysis bag and dialysis tube is free diffusion. After dialysis for a period of time, the concentration difference of the target molecules close to the dialysis membrane is close to zero, and the dialysis almost stops, while the concentration of the target molecules far away from the dialysis membrane is almost zero. change; when the target molecule increases the concentration difference near the dialysis membrane through diffusion, dialysis resumes again, so the dialysis efficiency is not fully exerted

[0004] When the diameter of the dialysis bag and dialysis tubing is large, the effect of uneven concentration difference becomes very significant, the dialysis efficiency is significantly reduced, and the time required to reach complete equilibrium is very long; in addition, the diffusion rate of large molecular weight target molecules is small, even if it is Dialysis of small samples also takes a long time to reach full equilibrium

The uneven concentration difference in the dialysis process is the biggest defect of the dialysis bag and dialysis tube. In clinical application, this problem is solved by keeping the sample flowing in a closed environment composed of dialysis membrane, pipeline and pump. However, the current laboratory There is no corresponding product

[0005] Some other defects of dialysis bags and dialysis tubing include: (1) The dialysis bag usually sinks to the bottom of the dialysate after being sealed with a sealing clip. , but the cost is high; (2) The dialysis bag and dialysis tube are not easy to clean after use. They can only be cleaned by repeated washing with running water. The cleaning effect is poor, and samples often remain on the inside of the membrane. Bags and dialysis tubes will increase the cost of experiments and are not environmentally friendly; (3) The mechanical strength of dialysis bags and dialysis tubes is not high, and they cannot be used under some environmental conditions that require pressurization or negative pressure; (4) Dialysis bags, dialysis tubes After the tube is aseptically treated, the sterility is not easy to maintain during use, especially during the sample transfer process, it is prone to contamination

Images