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A traditional Chinese medicine composition of Gengchen preparation, its preparation method, detection method and application

A technology of composition and traditional Chinese medicine, applied in the direction of drug combination, pharmaceutical formula, active ingredient of heterocyclic compounds, etc., can solve the problems of unguaranteed product quality, reduced amount of active ingredients, and unqualified product quality, so as to improve independent activities, improve Symptoms, the effect of improving depression

Active Publication Date: 2021-12-31
HEFEI YIFAN PHARMA MANAGEMENT
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

[0005] Depression is now beginning to be younger and younger, and the existing gengchen preparations contain velvet and musk, and their raw materials are obtained from rare animals, with limited output and high cost. They are urgently needed and low in cost. Alternative products used by younger people
[0006] In addition, because there are many products of Gengchen preparations, during its preparation, the extracted extract may be shoddy, resulting in a reduction in the amount of its main active ingredients, causing the quality of the product to be unqualified, and the quality of the product cannot be guaranteed. A method for effectively detecting and identifying gengchen preparations

Method used

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  • A traditional Chinese medicine composition of Gengchen preparation, its preparation method, detection method and application
  • A traditional Chinese medicine composition of Gengchen preparation, its preparation method, detection method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A kind of preparation of Gengchen preparation, it comprises the steps:

[0042] S1. Preparation of ginseng extract: take ginseng and add 4 to 6 times the weight of 65% to 75% ethanol solution, heat and reflux for extraction for 3 to 4 hours, filter out the dregs, recover the ethanol extract, and concentrate the ethanol extract (rotary Evaporate and concentrate, the temperature is 60-70 ℃) until the water is 15%-30% of the clear paste for later use, take the above-mentioned dregs and decoct twice with 3-5 times the weight of water, decoct for the first time for 3 hours, filter and take Decoct the dregs for the second time, add 3 to 5 times the weight of the dregs in water, decoct for 2 hours, filter the decoction, combine the two filtrates, add the above clear paste, and continue to concentrate until the water is 15% ~20%, get ginseng extract;

[0043] S2: Preparation of Cistanche Herba Extract: Take Cistanche Herba Extract and crush it into coarse powder, add 6 to 10 t...

Embodiment 2

[0047] Example 2 Effects of Gengchen Preparation on the Behavior of Depression Rats with Kidney-Yang Deficiency

[0048] The Gengchen preparation prepared on the basis of Example 1, and carry out following experiments:

[0049] Prescription: 20g ginseng extract, 20g epimedium extract, 20g cistanche extract, 10g oryzanol, 5g panax notoginseng powder, vitamin B 1 5g, vitamin E 20g, mixed extract 8g.

[0050] Preparation method: S1: Preparation of ginseng extract: take ginseng and add 5 times the weight of 70% ethanol solution, heat and reflux for extraction for 4 hours, filter out the medicinal residues, recover ethanol, concentrate until the water is 25% clear ointment for later use, take the above medicinal residues Decoct twice with 4 times the weight of water, decoct for 3 hours for the first time, decoct for 2 hours for the second time, filter the decoction, combine the filtrates, add the above clear paste, continue to concentrate until the water is 18%, and obtain ginseng...

Embodiment 3

[0083] Example 3 Simultaneous determination of the contents of echinacoside, verbascoside and icariin in Gengchen preparations by HPLC

[0084] According to literature research, the main components in Epimedium are icariin, etc., and the main chemical components in Cistanche are echinacoside and verbascoside, so for Gengchen preparations containing Epimedium extract and Cistanche extract , In terms of index component control, three components echinacoside, verbascoside and icariin can be selected for quality control. This experiment is an HPLC method for simultaneous determination of the contents of these three components in Gengchen preparation.

[0085] 1 Instruments and reagents

[0086] 1.1 Instruments Agilent 1200 high performance liquid chromatography; electronic balance, Mettler-Toledo.

[0087] 1.2 Reference substances Echinacoside reference substances, verbascoside reference substances, and icariin reference substances were all purchased from Shenzhen Faith Biotechno...

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Abstract

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition of Gengchen preparation, a preparation method, a detection method and application. The traditional Chinese medicine composition of the Gengchen preparation consists of the following raw materials in parts by weight: 17-23 parts of ginseng extract, 17-23 parts of epimedium extract, 17-23 parts of cistanche extract, 8-12 parts of oryzanol, and Panax notoginseng powder 10-15 parts, vitamin B 1 4-6 parts, vitamin E 17-23 parts, mixed extract 7-10 parts. The invention provides a new pharmaceutical application of Gengchen preparation for treating depression and menopausal syndrome caused by kidney yang deficiency, and the invention also provides a high-performance liquid chromatography method for simultaneous determination of the contents of several main active ingredients in Gengchen preparation Methods.

Description

technical field [0001] 本发明涉及中药领域,具体涉及一种更辰制剂的中药组合物、制备方法、检测方法及应用。 Background technique [0002] 更年期综合症是指由于生理性或病理性或手术,而引起的卵巢功能衰竭引起的雌激素分泌减少,进而引发女性全身大量受雌激素控制和支配的器官与组织的退行性变化,出现一系列以自主神经系统功能紊乱为主,伴有精神心理症状的一组症候群。该病由激素水平紊乱所引起,使更年期女性的生理和心理都会产生重大的影响,表现出生活能力降低,社会适应能力减退及身体不适的亚健康状态,严重时可导致抑郁,对妇女的身心健康、工作和生活危害极大。 [0003] 随着社会老龄化,此病的发病率有上升的趋势,因此日益受到人们的关注和重视。但是因其成因复杂性和临床表现的多样性,给治疗也带来了一定的困难。传统医学认为,妇女在绝经前后,肾气渐衰,天癸将竭,冲任二脉逐渐亏虚,精血日益不足,人体调节阴阳的能力减退。另针对抑郁症,也有专家通过研究提出,结合抑郁症的临床表现和临床辨治,肾阳虚是抑郁症发病的重要病机,其以肾阳虚为本质,形成了肾——脑——心——肝脏腑系统的功能紊乱,而导致抑郁症的发生、发展。 [0004] 目前,临床上一线的抗抑郁药主要包括选择性5-羟色胺再摄取抑制剂(SSRI,代表药物氟西汀、帕罗西汀、舍曲林、氟伏沙明、西酞普兰和艾司西酞普兰)、5-羟色胺和去甲肾上腺素再摄取抑制剂(SNRI,代表药物文拉法辛和度洛西汀)、去甲肾上腺素和特异性5-羟色胺能抗抑郁药(NaSSA,代表药物米氮平)等。传统的三环类、四环类抗抑郁药和单胺氧化酶抑制剂由于不良反应较大,应用明显减少。西药主要是对肾功能损伤较大,副作用强。 [0005] 抑郁症由于现在开始向年轻化、小龄化发展,且现有的更辰制剂由于含有鹿茸、麝香,其原料来源来自稀有动物获得,产量有限,且成本高,急需要用成本低,适于小龄化使用的替代产品。 [0006] 此外由于更辰制剂的产品较多,在其制备时,提取的浸膏或因以次充好,导致其主要的有效成分量减少,导致产品的质量不过关,产品的质量不能保证,亟需一种有效检测并鉴定更辰制剂的方法。 Contents of the invention [0007] 本发明的目的是提供一种更辰制剂的中药组合物、制...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P15/12A61P25/24G01N30/02G01N30/06G01N30/14G01N30/54A61K31/355A61K31/51A61K31/575
CPCA61K36/888A61K36/9066A61P15/12A61P25/24G01N30/02G01N30/06G01N30/14G01N30/54A61K31/355A61K31/51A61K31/575A61K36/232A61K36/258A61K36/296A61K36/64A61K36/815A61K2236/39A61K2236/333A61K2236/331G01N2030/062G01N2030/027A61K2300/00
Inventor 何枢衡吴建雄周文艳刘存鲍春影
Owner HEFEI YIFAN PHARMA MANAGEMENT
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