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Preparation method for small-particle size gold nanoparticles controllable in size

A gold nanoparticle, small particle size technology, applied in nanotechnology and other directions, can solve the problems of complex operation and high equipment dependence, and achieve the effect of uniform particle size and single shape

Inactive Publication Date: 2018-12-07
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the particle size of gold nanoparticles prepared by this method is mostly larger than 16nm, while the method for preparing gold nanoparticles with a particle size below 8nm is highly dependent on equipment and complicated to operate.

Method used

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  • Preparation method for small-particle size gold nanoparticles controllable in size
  • Preparation method for small-particle size gold nanoparticles controllable in size
  • Preparation method for small-particle size gold nanoparticles controllable in size

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Under ice-bath conditions, 0.4ml of chloroauric acid with a mass fraction of 1% was added to 25ml of secondary water, and then 2.0mg of polyvinylpyrrolidone (PVP) was added and stirred evenly. Then add 5ml of an aqueous solution containing 1mg of sodium borohydride, the solution turns from colorless to brown, adjust the speed to 480rpm, and continue to stir for 6 hours. After the reaction is completed, put it in a 4°C refrigerator and let it stand for 12h, the solution gradually turns pink. Then the solution was taken out and centrifuged to obtain gold nanoparticles with a small particle size.

Embodiment 2

[0022] Under ice-bath conditions, 0.4ml of chloroauric acid with a mass fraction of 1% was added to 25ml of secondary water, and then 3.0mg of polyvinylpyrrolidone (PVP) was added and stirred evenly. Then add 5ml of an aqueous solution containing 0.8mg of sodium borohydride, the solution turns from colorless to brown, adjust the speed to 480rpm, and continue to stir for 6 hours. After the reaction is completed, put it in a refrigerator at 4°C for 12 hours, and the solution gradually turns pink. , and then the solution was taken out and centrifuged to obtain gold nanoparticles with a small particle size.

Embodiment 3

[0024] Under ice-bath conditions, 0.4ml of chloroauric acid with a mass fraction of 1% was added to 25ml of secondary water, and then 2.0mg of polyvinylpyrrolidone (PVP) was added and stirred evenly. Then add 5ml of an aqueous solution containing 0.8mg of sodium borohydride, the solution turns from colorless to brown, adjust the speed to 480rpm, and continue to stir for 6 hours. After the reaction is completed, put it in a refrigerator at 4°C for 12 hours, and the solution gradually turns pink. , and then the solution was taken out and centrifuged to obtain gold nanoparticles with a small particle size.

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Abstract

The invention relates to a preparation method for small-particle size gold nanoparticles controllable in size. Through an aqueous phase oxidation-reduction method, by taking sodium borohydride as a reducing agent and polyvinylpyrrolidone (PVP) as a protective agent, chloroauric acid is reduced to the gold nanoparticles under an ice bath condition; characterization is performed on the gold nanoparticles, and thereby, the gold nanoparticles are less than 10 nm through observation. The small-particle size gold nanoparticles prepared by the preparation method disclosed by the invention can be usedfor the field of channel plugging of a mesoporous material, mark detection and catalysis.

Description

technical field [0001] The invention belongs to the field of gold nanoparticles and preparation thereof, in particular to a method for preparing small-diameter gold nanoparticles with controllable size. Background technique [0002] Nano-gold particles refer to gold particles with a size in the range of 1-100 nm. Generally, it is a hydrosol dispersed in water, so it is also called colloidal gold. Gold nanoparticles have the advantages of high electron density, dielectric properties, catalysis and good biocompatibility. As one of the four major modern labeling technologies, nano-gold labeling technology can be used for qualitative or semi-quantitative rapid immunoassays and for binding with Staphylococcus protein A, immunoglobulin, toxins, Glycoproteins, enzymes, antibiotics, hormones, bovine serum albumin, etc. are non-covalently combined, showing the advantages of simplicity, speed, and high sensitivity. and its important role. Gold nanoparticles also have good catalyti...

Claims

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Application Information

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IPC IPC(8): B22F9/24B82Y40/00
CPCB22F9/24B82Y40/00
Inventor 代昭韩阳李爽
Owner TIANJIN POLYTECHNIC UNIV
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