Device provided with seven laser optical tweezers for capturing particles or cells
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An optical tweezers and particle technology, applied in the field of optical tweezers, can solve the problems of inability to realize the cell sorting function, complicated sorting process operation, etc., and achieve the effect of improving the operation efficiency and precision, improving the capture characteristics, and facilitating the operation and use.
Inactive Publication Date: 2018-12-04
长沙健金电子技术有限公司
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[0007] The entire sorting process of this method is complicated to operate. When the surface of the cells to be sorted does not contain antigens or the cells to be sorted are mutant individuals or the cells to be sorted are bacteria, this method cannot realize the cell sorting function.
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[0039] The user uses a seven-laser optical tweezers of the present invention to capture particles or cells, the eyepiece 101 observes abnormal or unqualified particles or cells 704 in the particle or cell chamber 7, and picks out unqualified particles or cells 704, (as shown in the attached Figure 4 shown), turn on the first optical tweezers device 10 and the second optical tweezers device 11, wherein the first optical tweezers emitter 1002, the second optical tweezers emitter 14 and the third optical tweezers emitter 15 capture unqualified particles or cells 704, wherein, the first optical tweezers emitter 1002 is used for unqualified particles or cells 704, the third optical tweezers emitter 15 is used for clamping larger volumes or for simultaneously clamping multiple particles or cells, and the second optical tweezers The emitter 14 is used to locate the position of the particle or cell, and hold up the particle or cell. The optical tweezers produced by the first optical t...
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Abstract
The invention discloses a device provided with seven laser optical tweezers for capturing particles or cells. The device includes a lens barrel, a moving stage, a base and an optical tweezers device.A light-transmitting plate is arranged in the middle of the moving stage. A particle or cell chamber is arranged on the light transmitting plate. The optical tweezers device comprises a first opticaltweezers device disposed on the lens barrel and a second optical tweezers device disposed on the base. The first optical tweezers device includes a fixed seat connected to the lens barrel and a firstoptical tweezers emitter disposed on the fixed seat, and the second optical tweezers device includes a lifting chassis connected to the base, a rotating chassis disposed on the lifting chassis, and asecond optical tweezers emitter and a third optical tweezers emitter disposed on the rotating chassis. Compared with a conventional optical tweezers technology, the seven laser optical tweezers provided by the invention can extract cells with cell volume and cell mass 60 to 70 times of that of the common optical tweezers technology and simultaneously achieves the optical tweezers effect of driving, controlling or separating multiple particles.
Description
technical field [0001] The invention relates to the technical field of optical tweezers, in particular to a device for capturing particles or cells by optical tweezers with seven lasers. Background technique [0002] In the fields of life science, chemistry, and nanotechnology, it is necessary to perform various manipulations and tests on tiny objects, such as cell nuclei, DNA chains, molecular groups, and micro-mechanical structures, such as handling, cutting, peeling, grafting, injection, assembly, and curing. , activation, fluorescence detection, electrophoresis detection, etc. Common microscopic manipulation methods include mechanical probes, molecular tweezers, optical tweezers, etc., in which mechanical probes can puncture cells; molecular tweezers can adsorb cells on the front of capillaries to quantitatively measure cell membrane Ion channels; optical tweezers can capture and move tiny particles by relying on the sharply changing gradient light field in the focused s...
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