Four-laser device for capturing particles or cells through optical tweezers
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
An optical tweezers and particle technology, applied in the field of optical tweezers, can solve the problems of complicated sorting process operation, inability to realize cell sorting function, etc., and achieve the effects of improving capture characteristics, improving operation efficiency and precision, and being easy to configure and use.
Inactive Publication Date: 2018-11-23
长沙健金电子技术有限公司
View PDF10 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0007] The entire sorting process of this method is complicated to operate. When the surface of the cells to be sorted does not contain antigens or the cells to be sorted are mutant individuals or the cells to be sorted are bacteria, this method cannot realize the cell sorting function.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
specific Embodiment
[0039] The user uses a four-laser optical tweezers of the present invention to capture particles or cells, observes abnormal or unqualified particles or cells in the particle or cell chamber through the lens barrel, and selects unqualified particles or cells, (as shown in the attached Figure 4 shown), turn on the optical tweezers generator, wherein the optical tweezers generated by the optical tweezers generator gather around the selected cells or particles in the particle or cell chamber, similar to claws grabbing particles or cells, and when capturing At the same time, through the X-axis driving mechanism 14 provided, the Y-axis moving mechanism 15 moves the clamped cells or particles, and the height of the optical tweezers generator can be adjusted through the Z-axis moving mechanism 16, so that the height of the optical tweezers generator emits Optical tweezers pick up particles or cells of different heights, so as to pick out particles or cells with abnormal volume or unq...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention discloses a four-laser device for capturing particles or cells through optical tweezers, and the device comprises a pedestal, an objective table, and a lens cone. One side of the pedestal is provided with a support arm, and the support arm is connected with the objective table and the lens cone. The particles or cells are disposed on the objective table, and the objective table is provided with an avoiding hole. A light transmitting plate connected with the particles or cells is disposed on the avoiding hole, and the bottom of the light transmitting plate is provided with opticaltweezers equipment connected with the pedestal. The optical tweezers equipment comprises a movable platform, a light source which is disposed on the movable platform, and four optical tweezers emitters, wherein the generated laser tweezers can pass through the particles or cells on the light transmitting plate to be focused around the particles or cells. Compared with the conventional optical tweezers technique, the device provided with the four optical tweezers emitters, and the volume and mass of the extracted cells are 30-40 times of the volume and mass of the cells extracted through the common optical tweezers technique, and the drive, control and separation effects of a plurality of particles are acheived.
Description
technical field [0001] The invention relates to the technical field of optical tweezers, in particular to a device for capturing particles or cells by optical tweezers with four lasers. Background technique [0002] In the fields of life science, chemistry, and nanotechnology, it is necessary to perform various manipulations and tests on tiny objects, such as cell nuclei, DNA chains, molecular groups, and micro-mechanical structures, such as handling, cutting, peeling, grafting, injection, assembly, and curing. , activation, fluorescence detection, electrophoresis detection, etc. Common microscopic manipulation methods include mechanical probes, molecular tweezers, optical tweezers, etc., in which mechanical probes can puncture cells; molecular tweezers can adsorb cells on the front of capillaries to quantitatively measure cell membrane Ion channels; optical tweezers can capture and move tiny particles by relying on the sharply changing gradient light field in the focused sp...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.