Establishing method of experimental lower limb rhythm movement rat model and applications of establishing method

Abstract

The invention relates to the field of biology, and in particular relates to an establishing method of an experimental lower limb rhythm movement rat model and applications of the establishing method.The establishing method comprises the following steps: S1, carrying out spinal nerve lower limb movement functional localization simulation on a rat by adopting a method of electronics; S2, carrying out three-dimensional scanning type electrical stimulation, and recording the key points of CPG; S3, fixing a silica gel tube through which an electrode wire penetrates to the spinous process of the spine by adopting dental cement; and S4, acquiring electromyographic signals of key muscle relevant to lower limb movement. For the method disclosed by the invention, the key points of CPG movement arefound through microstimulation in the spine, so that the regulation for the paralyzed lower limb movement is realized, and a research basis is provided for greatly reducing the complexity of the surgery and reducing the number of implantation neural electrodes in clinical practice in the future.

Description

technical field [0001] The invention relates to the field of biology, in particular to a method for establishing an experimental lower limb rhythmic movement rat model and its application. Background technique [0002] Spinal cord injury leads to motor dysfunction of the limbs below the injured segment, which will not only bring physical and mental harm to the patient, but also cause a huge economic burden to the family and the whole society. Therefore, reconstructing the motor function of paralyzed lower limbs has always been an important topic in neuroscience research. [0003] In recent years, countries around the world have formulated a series of brain-spinal cord-related neural engineering and intelligent rehabilitation programs, which have brought hope for the reconstruction of motor functions of paralyzed limbs. For example, at the opening ceremony of the 2014 World Cup in Brazil, a patient with a spinal cord injury caused by a car accident and who had been paralyzed...

AI Technical Summary

Problems solved by technology

Scholars such as Pcekham have successfully controlled the movement of the hindlimbs using a needle-electric FES system with up to 62 channels. Domestic scholars have also successfully designed a multi-channel in vitro functional electrical stimulator for rehabilitation training. However, due to the complex structure and cumbersome algorithms of these devices, reconstruction is complicated. Exercise requires more electrodes to stimulate multiple muscle groups, and the corresponding coordination problems are more difficult to solve

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