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Use of salidroside and analogue thereof in dynamically filling regenerated pancreas islet in pancreatic decellularized scaffold

A decellularized scaffold and salidroside technology, which is applied in the application field of salidroside and its analogs in the dynamic perfusion of pancreatic decellularized scaffolds and replanted islets, can solve the shortage of donor tissue sources and cannot satisfy the huge To meet the clinical needs of the patient population and other issues, to achieve the effect of promoting the function of pancreatic islets and achieving the exact effect

Inactive Publication Date: 2018-11-23
AFFILIATED HOSPITAL OF NANTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pancreatic islet or pancreas transplantation, as an ideal treatment for insulin-dependent diabetes, is currently a hot spot in the field of regenerative medicine research. However, the shortage of donor tissue sources is far from meeting the clinical needs of a large patient population.

Method used

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  • Use of salidroside and analogue thereof in dynamically filling regenerated pancreas islet in pancreatic decellularized scaffold
  • Use of salidroside and analogue thereof in dynamically filling regenerated pancreas islet in pancreatic decellularized scaffold
  • Use of salidroside and analogue thereof in dynamically filling regenerated pancreas islet in pancreatic decellularized scaffold

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Experimental program
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Embodiment Construction

[0020] An application of salidroside and its analogues in the preparation of preparations for antagonizing islet mechanical damage and central hypoxia and promoting islet function in three-dimensional dynamic perfusion of pancreatic decellularized scaffolds and replanted islets.

[0021] The antagonizing islet mechanical injury and central hypoxia and promoting islet function are exerted by inhibiting the activation of NLRP3 inflammasome mediated by the ROS-TXNIP axis.

[0022] The salidroside and its analogs are: the 4-position of the benzene ring is a phenolic hydroxyl group, and the sugar group donor is glucose, galactose, N-acetylglucosamine, and glucosamine, and the specific names are as follows: 1-(4-hydroxyl ) Benzyl-β-D-glucopyranoside, 1-(4-hydroxy)benzyl-β-D-galactopyranoside, 2-(4-hydroxy)phenylethyl-β-D- Glucopyranoside (Salidroside), 2-(4-Hydroxy) Phenylethyl-β-D-Galactopyranoside, 3-(4-Hydroxy) Phenylpropyl-β-D-Glucopyranoside Glycoside, 3-(4-hydroxy)phenylpropy...

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Abstract

The invention discloses use of salidroside and analogue thereof in dynamically filling regenerated pancreas islet in a pancreatic decellularized scaffold, specifically application of salidroside and analogue thereof in preparing reagents for resisting pancreas islet mechanical damages and center anoxia, and promoting a pancreas islet function in dynamically filling regenerated pancreas islet in athree-dimensional mode in the pancreatic decellularized scaffold. The effect is exact.

Description

technical field [0001] The present invention relates to the field of pancreatic tissue engineering, in particular to the new application of salidroside and its analogs in three-dimensional dynamic perfusion and replantation of pancreatic islets to construct functional pancreatic tissue, and in particular to the use of salidroside and its analogs in alleviating Mechanical damage during islet extraction and antagonism against hypoxia in the islet center during dynamic perfusion and replantation of pancreatic decellularized scaffolds, improving islet function, and constructing tissue-engineered pancreas with long-term stable blood sugar regulation function. Background technique [0002] Diabetes is a global disease characterized by elevated blood sugar that seriously endangers human health. Among them, type 1 diabetes is a self-metabolic disease caused by autoimmune T cells attacking β cells, resulting in an absolute lack of insulin secretion, and must rely on exogenous insulin...

Claims

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Application Information

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IPC IPC(8): A61K31/7032A61P5/00A61P5/48
CPCA61K31/7032A61P5/00A61P5/48
Inventor 郭益冰徐联成黄徐阳李晓红陆晶晶熊益程陆玉华王志伟
Owner AFFILIATED HOSPITAL OF NANTONG UNIV
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