Medicine for treating liver cancer and application

A technology for the treatment of liver cancer and drugs, applied in the field of medicine, can solve the problems of unsatisfactory curative effect, further research is still needed, and there is no treatment method for liver cancer, so as to achieve the effect of improving the extraction rate

Inactive Publication Date: 2018-11-16
GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, 90% of patients lost the chance of surgery due to large tumors or liver cirrhosis; normal liver cells are sensitive to radiation, while liver cancer cells are less sensitive, and it takes >4000cGy to obtain certain local control; local ablation therapy can achieve local Tumor control, symptom relief, etc., can be used as a treatment option for patients who cannot accept surgical resection, but it is only effective for liver cancer with tumors smaller than 5cm; the partial remission rate of chemotherapy drugs for liver cancer is below 20%, and the curative effect is not ideal; Catheter chemoembolization (TACE) or TACE plus portal vein embolization (PVE) has improved the effective rate and improved the survival time, but further studies are needed in terms of complete arterial embolization, optimal drug combination, and optimal embolization model. Research; the effective rate of biological targeted therapy for primary liver cancer is less than 10%
In summary, modern medicine still has no good treatment for advanced primary liver cancer.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A kind of medicine for the treatment of liver cancer, comprising the extract of Rhizoma chinensis, the preparation of which extract comprises the following steps:

[0027] S1, placing the large bark bone in boiling water for extraction to obtain a water extract;

[0028] S2. Separating and purifying the water extract in S1 to obtain the Dabagu extract.

[0029] The drug for the treatment of liver cancer, in S1, use boiling water to extract twice, each time for 2 hours, and combine the two extractions to obtain the water extract; the separation and purification of the water extract in S2 specifically includes: extracting the water extract at 80 Concentrate to a specific gravity of 1.05 at a temperature of °C, then use D101 macroporous resin to elute, the eluent is successively ethanol with a volume fraction of 20%, 50%, and 95%, collect 95% ethanol eluate, remove ethanol, Concentrate to a specific gravity of 1.08, that is, the extract of Dabagu.

Embodiment 2

[0031] A kind of medicine for the treatment of liver cancer, comprising the extract of Rhizoma chinensis, the preparation of which extract comprises the following steps:

[0032] S1, placing the large bark bone in boiling water for extraction to obtain a water extract;

[0033] S2. Separating and purifying the water extract in S1 to obtain the Dabagu extract.

[0034] The drug for the treatment of liver cancer, in S1, use boiling water to extract twice, each time for 2 hours, and combine the two extractions to obtain the water extract; the separation and purification of the water extract in S2 specifically includes: extracting the water extract at 80 Concentrate to a specific gravity of 1.05 at a temperature of °C, then use D101 macroporous resin to elute, the eluent is successively ethanol with a volume fraction of 20%, 50%, and 95%, collect 95% ethanol eluate, remove ethanol, Concentrate to a specific gravity of 1.08, that is, the extract of Dabagu.

[0035] The medicine f...

Embodiment 3

[0044] A kind of medicine for the treatment of liver cancer, comprising the extract of Rhizoma chinensis, the preparation of which extract comprises the following steps:

[0045] S1, placing the large bark bone in boiling water for extraction to obtain a water extract;

[0046] S2. Separating and purifying the water extract in S1 to obtain the Dabagu extract.

[0047] The drug for the treatment of liver cancer, in S1, use boiling water to extract twice, each time for 2 hours, and combine the two extractions to obtain the water extract; the separation and purification of the water extract in S2 specifically includes: extracting the water extract at 80 Concentrate to a specific gravity of 1.05 at a temperature of °C, then use D101 macroporous resin to elute, the eluent is successively ethanol with a volume fraction of 20%, 50%, and 95%, collect 95% ethanol eluate, remove ethanol, Concentrate to a specific gravity of 1.08, that is, the extract of Dabagu.

[0048] The medicine f...

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PUM

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Abstract

The invention discloses a medicine for treating liver cancer. The medicine comprises adhatoda ventricosa extracts. A preparation method of the adhatoda ventricosa extracts comprises the following steps that S1, adhatoda ventricosa is put into boiled water for extraction to obtain an aqueous extract solution; S2, after the aqueous extract solution obtained in S1 is separated and purified, the adhatoda ventricosa extracts are obtained. The medicine for treating liver cancer comprises the adhatoda ventricosa extracts, and experiments show that the adhatoda ventricosa extracts have a remarkable inhibition effect on growth of BEL-7402 and Hep-B3 liver cancer cell strains.

Description

technical field [0001] The invention relates to the technical field of medicine. More specifically, the present invention relates to a medicine for treating liver cancer and its application. Background technique [0002] Primary liver cancer is one of the common malignant tumors in my country. The mortality rate is high, ranking third in the order of malignant tumor deaths after stomach and esophagus, and ranking second in rural areas in some areas, second only to gastric cancer. About 110,000 people die from liver cancer every year in my country, accounting for 45% of the world's liver cancer deaths. Therefore, it is urgent for clinical oncologists to strengthen the research on the treatment of primary liver cancer, prolong the survival period of patients, improve the curative effect and improve the quality of life of patients. The main treatment for liver cancer is surgical resection, and the 1-year, 3-year and 5-year survival rates after early operation are 80-92%, 61-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/19A61K47/46A61K36/9066A61P35/00A61P31/14A61K35/583A61K35/62
CPCA61K35/583A61K35/62A61K36/07A61K36/12A61K36/13A61K36/185A61K36/19A61K36/24A61K36/27A61K36/284A61K36/288A61K36/30A61K36/34A61K36/36A61K36/37A61K36/41A61K36/424A61K36/428A61K36/47A61K36/48A61K36/484A61K36/489A61K36/515A61K36/53A61K36/536A61K36/56A61K36/66A61K36/704A61K36/714A61K36/73A61K36/74A61K36/81A61K36/84A61K36/88A61K36/8945A61K36/896A61K36/9066A61K47/46A61K2236/19A61K2236/331A61K2236/39A61K2236/51A61K2236/55A61P31/14A61P35/00A61K2300/00
Inventor 韦范王雯丽周小雷缪剑华欧春丽龚小妹王硕莫单丹唐炳兰侯小利宋志军
Owner GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS
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