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Application of mitochondrion MT-CO1 in pyemia screening

A MT-CO1, sepsis technology, applied in the direction of microbial determination/inspection, biochemical equipment and methods, etc., can solve the problem that the correlation needs to be further clarified, and achieve the effect of being conducive to infection prevention and treatment

Inactive Publication Date: 2018-11-13
朱海燕 +1
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Problems solved by technology

However, the link between mitochondria and sepsis remains to be clarified

Method used

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  • Application of mitochondrion MT-CO1 in pyemia screening
  • Application of mitochondrion MT-CO1 in pyemia screening
  • Application of mitochondrion MT-CO1 in pyemia screening

Examples

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Embodiment 1

[0028] 1 Materials and methods

[0029] 1.1 Research object

[0030] According to the results of complete mitochondrial DNA sequence analysis of 100 sepsis patients in the previous case group, one sepsis patient carrying the mtDNAT6459C mutation was the proband. The proband was a male from Baoding, Hebei Province, 49 years old , the initial onset of oral and maxillofacial infection, secondary pneumonia, mediastinal infection, liver failure, coagulation dysfunction and other manifestations, according to the Sepsis-3 diagnostic criteria (Marshall JC.Sepsis-3: What is the Meaning of a Definition? CRIT CARE MED 2016;44(8):1459-1460), the diagnosis of sepsis is clear. The maternal genetic members of the proband in the family are Ⅰ-1, Ⅱ-1, Ⅱ-2, and Ⅱ-4, and the non-maternal genetic members are Ⅱ-3, Ⅲ-1, Ⅲ-2. Inclusion criteria for patients with sepsis in the case group: This experiment was reviewed and approved by the Ethics Committee of the General Hospital of the Chinese People'...

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Abstract

The invention relates to the field of disease diagnosis or screening, discloses application of a mitochondrion MT-CO1 in pyemia screening, and particularly discloses a method for screening individualssusceptible to pyemia on nondiagnostic purpose. The method includes: analyzing whether a basic group at the 6459th position of an individual mitochondrial MT-CO1 gene mutates or not and / or amino acidat the 186th position of a mitochondrial MT-CO1 polypeptide chain mutates or not. The invention further discloses application of a reagent, used for analyzing whether the basic group at the 6459th position of the individual mitochondrial MT-CO1 gene analyzing and / or the amino acid at the 186th position of the mitochondrial MT-CO1 polypeptide chain mutates or not, in preparation of medical instruments for pyemia diagnosis or screening. Based on the mitochondrial MT-CO1 gene or polypeptide chain, early diagnosis or screening of pyemia can be achieved, which is beneficial to infection preventionof susceptible individuals.

Description

technical field [0001] The invention relates to the field of disease diagnosis or screening, in particular to the use of mitochondrial MT-CO1 in screening sepsis. Background technique [0002] Sepsis is a clinical syndrome in which excessive and uncontrolled systemic inflammation induced by infectious factors leads to multiple organ dysfunction and even failure. With the development of modern medicine, especially the progress of microbiology and immunology, the research on the pathogenesis of sepsis has been deepened. The emergence of antibiotics and organ support technology has played an important role in promoting the treatment of sepsis. Nevertheless, the morbidity and mortality of sepsis remain high. It is estimated that as many as 19 million people suffer from the disease every year worldwide, and the case fatality rate is still as high as 20-30%. The clinical manifestations of patients with sepsis are very diverse. Even with the same infection, the occurrence, devel...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/156
Inventor 朱海燕韩国鑫申晓东王朔朔
Owner 朱海燕
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