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Posterior ocular fibrosis inhibition by antagonizing placental growth factor

A technology of placental growth factor and growth factor, applied in the field of eye treatment, can solve problems such as lack of effect

Inactive Publication Date: 2018-11-09
OXURION NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Friedlander (J Clin Invest 2007,117:576-586) summarized the effect of VEGF antagonists on back of eye lack of fibrosis

Method used

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  • Posterior ocular fibrosis inhibition by antagonizing placental growth factor
  • Posterior ocular fibrosis inhibition by antagonizing placental growth factor
  • Posterior ocular fibrosis inhibition by antagonizing placental growth factor

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Experimental program
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Embodiment

[0141] 1 Introduction

[0142] This study investigated the effect of anti-PlGF antibodies (mouse PLGF inhibitory antibody 5D11D4 or human PlGF inhibitory antibody 16D3, ThromboGenics, Leuven, Belgium) on one or more of neovascularization, inflammation and collagen deposition in a mouse model of CNV. Dose-response potency of PlGF inhibition; and comparing it with equimolar concentrations of anti-VEGF-R2 antibody (DC101, produced by hybridoma cell line ATCC HB-11534), aflibercept ( Bayer), triamcinolone acetonide (TAAC; Bristol-Myers Squibb) was compared with the anti-mouse VEGF antibody B20 (Liang et al. 2006, JBiol Chem 281:951-961). TAAC was used as a reference for inflammation and fibrosis. Based on the activity in the mouse CNV model described by Takata et al. (Takata et al., Sci Rep 2015, 5:9898), a single injection of 1 μL TAAC was chosen as the treatment regimen. The effects of anti-PlGF antibody 5D11D4 and anti-VEGF-R2 antibody DC101 on RGC survival were studied ...

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Abstract

The invention is situated in the field of ocular therapies. In particular it refers to antagonists of placental growth factor for interfering with posterior ocular fibrosis.

Description

technical field [0001] The present invention relates to the field of eye therapy. Specifically, it relates to antagonists of placental growth factor for interfering with posterior eye fibrosis. Background technique [0002] The retina of the eye (most of the posterior segment of the eye; the back of the eye) is part of the central nervous system (CNS). As such, the wound-healing response of the retina is similar to that of the brain, which Friedlander termed gliosis (glial cell-mediated fibrosis). This is in contrast to wound-healing responses in non-CNS tissues or organs in general and the anterior segment of the eye (front of the eye), such as the cornea and trabecular meshwork, specifically termed fibrosis (fibroblast-mediated fibrosis) (Friedlander 2007 , J Clin Invest, 117:576-586). [0003] Any type of retinal disease or disorder caused by or accompanied by inflammation and / or neovascularization results in gliosis and fibrous scarring. This gliosis, or fibrosis at ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/22C07K16/28A61P27/02
CPCC07K16/22A61K2039/505A61K2039/507A61K2039/54A61K2039/545C07K2317/24C07K2317/76C07K16/2863A61P27/02A61K45/06A61K2300/00
Inventor 蒂内·范贝尔根巴特·乔恩克斯琼·费恩
Owner OXURION NV
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