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Antifungal application of fraxetin

A technology of fencetin and antifungal drugs, which is applied in the field of medicine, can solve the problems of no fencetin and no antifungal effect of fencetin, and achieve the effects of improving antifungal effect, saving medical expenses, and enhancing the inhibitory effect

Active Publication Date: 2018-11-09
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern pharmacological studies have shown that fencetin has pharmacological effects such as antibacterial, anti-oxidation, anti-tumor, and liver protection. However, there are no reports on the antifungal effect of fencetin at home and abroad, and there is no report of fencetin as an antifungal drug synergist. A report on the combined use of antifungal azoles in the treatment of fungal diseases

Method used

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  • Antifungal application of fraxetin
  • Antifungal application of fraxetin
  • Antifungal application of fraxetin

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Experimental program
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Embodiment Construction

[0019] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0020] 1. The effect of fencetin alone on different fungi

[0021] 1. Test drug

[0022] Echinocetin: purchased from Chengdu Desite Biotechnology Co., Ltd., purity ≥ 99%, batch number DST170411-006.

[0023] Fluconazole (FLC)): sigma company, lot number 036M4709V.

[0024] Dimethyl sulfoxide: Tianjin Tianli Chemical Reagent Co., Ltd.

[0025] All reagents were stored at -20°C. Before the experiment, the drug was taken out and placed in a 35°C incubator to melt, mixed well, and pharmacodynamic tests were carried out respectively.

[0026] 2. Strains

[0027] Strains used, including:

[0028] 1) Sensitive strains: sensitive Candida albicans (SC5314), Candida parapsilosis (22019) and Cryptococcus neoformans (32609);

[0029] 2) Drug-resistant strains: drug-resistant strains: drug-resistan...

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Abstract

The invention discloses antifungal application of fraxetin, belonging to the technical field of medicines. In-vitro experiments show that fraxetin has relatively good inhibition effect to the fungi, is capable of restoring the effect of an antifungal drug, namely fluconazole to drug-resistant fungi and therefore can be taken as the antifungal drug and a synergist for the antifungal drug. Accordingto the antifungal application, the new use of fraxetin is opened up, fraxetin is used as the antifungal drug and the synergist for the antifungal drug, a new candidate drug is provided for the fungustreatment, and the antifungal effects of existing drugs are improved. Under the conditions that clinical fungus drug resistance becomes common increasingly and the drug resistance level becomes serious increasingly, the effect of an antifungal drug to the drug-resistant fungi is restored, and the use dosage of the antifungal drug is reduced, so that the medical expense of a patient is saved, andthe toxic and side effects of the drugs are reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the antifungal application of afracetin. Background technique [0002] Auretin belongs to coumarin compounds and is one of the active ingredients contained in the leaves of water rhinoceros and Hima ash. It has the effect of resisting Shigella, and is clinically used to treat children with acute bacillary dysentery. Modern pharmacological studies have shown that fencetin has pharmacological effects such as antibacterial, anti-oxidation, anti-tumor, and liver protection. However, there are no reports on the antifungal effect of fencetin at home and abroad, and there is no report of fencetin as an antifungal drug synergist. Reports of combined use with antifungal azoles in the treatment of mycoses. Contents of the invention [0003] The object of the present invention is to provide the antifungal application of afracetin. [0004] The present invention is achieved...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/37A61K45/06A61K31/4196A61P31/10
CPCA61K31/37A61K31/4196A61K45/06A61P31/10A61K2300/00
Inventor 刘伟乔欣悦张子悦
Owner SHAANXI UNIV OF SCI & TECH
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