Systems and methods for quantitative estimation of HIFU damage viscoelasticity by monitoring pulsed acoustic radiation force shear waves with laser doppler

Abstract

The invention discloses a system and a method for quantitatively estimating HIFU (High Intensity Focused Ultrasound) damage viscoelasticity through pulsed acoustic radiation force shear waves monitored by a laser Doppler. According to the system, a synchronizing signal control system is connected with an arbitrary waveform generator and a high-speed data acquisition card, and the arbitrary waveform generator is connected with a high intensity focused ultrasound transducer by virtue of a power amplifier and an impendence-matching network; the high intensity focused ultrasound transducer is arranged outside a water tank, and detected imitated body tissues are arranged inside the water tank and connected with one three-dimensional movement device; laser Doppler equipment is arranged outside the water tank and connected with another three-dimensional movement device; and the output end of the laser Doppler equipment is connected with a PC (Personal Computer) via the high-speed data acquisition card. According to the system disclosed by the invention, single pulse acts on the imitated body tissues, so that ultrasonic action time and ultrasonic radiation dose can be effectively reduced;the acoustic radiation force shear waves are tracked by utilizing laser Doppler, the wave velocity and attenuation coefficient of the shear waves are obtained by using a 2D-FT algorithm, the shearingmodulus of elasticity and shear viscosity coefficient are further analyzed, and the defects of the conventional SDUV (Shearwave Dispersion Ultrasound Vibrometry) method are overcome.

Description

technical field [0001] The invention belongs to the technical field of biomedical ultrasonic measurement, and in particular relates to an experimental system and method for monitoring acoustic radiation force shear wave and estimating high-intensity focused ultrasound (HIFU) damage viscoelasticity using 2D-FT algorithm laser Doppler. Background technique [0002] High intensity focused ultrasound (HIFU) is a non-invasive, safe and efficient treatment method. In order to effectively guide the treatment focus of HIFU and control the dose of ultrasound treatment, real-time monitoring and evaluation of the treatment process of HIFU is required. . During HIFU treatment, tissue protein denatures to form irreversible coagulation necrosis, which will change the mechanical properties of the tissue. Therefore, changes in the mechanical properties, especially viscoelastic properties, of the tissue target area under the action of HIFU Real-time monitoring is performed to evaluate the t...

AI Technical Summary

Problems solved by technology

The present invention uses a single pulse to act on the phantom tissue, and applies the laser Doppler technology to the monitoring of shear waves inside the transparent phantom, so as to overcome the shortcomings of using continuous waves to act on the phantom tissue in the prior art, and realizes the laser The breakthrough of Doppler technology applied to the interior of transparent phantom. At the same time, the use of 2D-FT-based algorithm overcomes the inability to measure the attenuation coefficient of the traditional SDUV method, and greatly improves the measurement efficiency

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