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Antitumor drug capable of relieving immunosuppression and application of antitumor drug

An anti-tumor drug and immunosuppressive technology, applied in the field of biomedicine to achieve the effects of alleviating pain, inhibiting tumor growth, and reducing immunosuppression

Pending Publication Date: 2018-11-02
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, so far there is no report on the application of 2,3-indoloquinone in drugs that help fight melanoma and can alleviate the negative effects of chemotherapy drugs

Method used

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  • Antitumor drug capable of relieving immunosuppression and application of antitumor drug
  • Antitumor drug capable of relieving immunosuppression and application of antitumor drug
  • Antitumor drug capable of relieving immunosuppression and application of antitumor drug

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Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0017] In this experiment, female 6-8-week-old C57BL / 6 inbred mice were purchased from Beijing Huafukang Biotechnology Co., Ltd.

[0018] The C57 mice were randomly divided into four groups as Example 1-4, respectively tragacanth control group, 2,3-indole quinone experimental group, 5-fluorouracil positive control group and two drugs (2,3-indole quinone Doxyquinone and 5-fluorouracil) combination group.

[0019] Preparation of experimental drugs

[0020] (1) Prepare 1.25% tragacanth gum solution: adjust the balance to zero, accurately weigh 2.5g tragacanth gum powder, take a clean beaker and add 200ml of ultrapure water, spread the weighed tragacanth gum powder evenly on the water surface , stand at room temperature overnight, wait for it to dissolve by itself, observe whether there is any remaining powder the next day, choose water bath ultrasonic or magnetic stirring to completely dissolve the tragacanth gum, and be careful not to form agglomerates;

[0021] (2) Preparatio...

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Abstract

The invention belongs to the field of biological medicine and relates to an antitumor drug capable of relieving immunosuppression. The antitumor drug contains active ingredients including 2,3-dioxoindoline and / or 5-fluorouracil and has the function of inhibiting melanoma cell proliferation without reducing immunosuppression. 2,3-dioxoindoline has a function of obviously suppressing tumor growth and assists in antitumor effect of 5-fluorouracil; 2,3-dioxoindoline has protective effect and anti-inflammatory effect on the immune system in vivo, and has particularly obvious protective effect on neutrophil granulocytes and NK cells, and the number of immune cells in the spleen has no obvious change; 2,3-dioxoindoline further has obvious protective effect on immune cells of peripheral tissue ofbone marrow and can relieve bone marrow suppression; after combination with 5-fluorouracil, 2,3-dioxoindoline has the effect of relieving immunosuppression of 5-fluorouracil. According to the antitumor drug, a new therapeutic target is found for solving side effects of chemotherapeutic drugs clinically, and pain of a cancer patient in chemotherapy is relieved.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to an antitumor compound capable of alleviating immunosuppression, and has the application of inhibiting melanoma cell proliferation without reducing immunosuppression. Background technique [0002] Malignant melanoma is a highly aggressive cancer that accounts for 60-80% of skin cancer deaths. Melanoma originates from a type of pigment-producing cells called melanocytes, which are found widely in the skin and eyes, while the body Less elsewhere, melanocytes originate in the embryonic neural crest and migrate to the epidermis where they produce melanin and subsequently migrate into adjacent keratinocytes. Malignant melanoma, the deadliest of all skin cancers and can arise from any tissue where melanocytes are present, is by far the most common form of skin melanoma, accounting for more than 90% of all melanoma cases. Melanoma has been a very rare cancer in the past, but its incidence has be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/513A61K31/404A61P37/02A61P29/00A61P35/00
CPCA61K31/404A61K31/513A61P29/00A61P35/00A61P37/02A61K2300/00
Inventor 张继国赵斌王晓丹唐华李雅琳
Owner TAISHAN MEDICAL UNIV
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